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Male Genital System
Path assessment 12
27
Pathology
Graduate
01/26/2012

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Cards

Term
Hypospadias
Definition
Ventral Side
Most Common
Faulty closure of urethral folds
Term
Epispadias
Definition
Dorsal Side
Defect in genital tubercle
Term
Phimosis
Definition
Inability to easily retract the foreskin
Causes Inflammation
Term
Balanitis
Definition
Glans inflammation
Term
Posthitis
Definition
Foreskin inflammation
Term
Balanoposthitis
Definition
Inflammation of Glans and foreskin
Smegma accumulation
Poor Hygeine
Term
Penis-Condyloma
Definition
Warty
cauliflower like growths
HPV 6 or 11
Exuberant exophytic growth pattern
Not premalignant
Term
Penis Carcinoma in situ
Definition
HPV 16 related
Red, slightly raised, rough, painless, nonulcerated lesions

Bowen disease-> SCC, Pts>35
Term
Erythroplasia of Queyrat
Definition
On Glans
Single Erythematous plaque
Uncircumsized
5th decade
-> SCC
Term
Bowenoid Papulosis
Definition
Wart-Like
contain HPV 16
Term
Penis Squamous Carcinoma
Definition
Most Frequent
ages 40-70
50% HPV 16 and 18
Uncircumsized
Poor Hygiens, Smoking, STD, Carcinoma in situ
Term
Cryptorchidism
Definition
Undescended testes
Associated with Germ Cell tumors (Seminoma, embryonal)
Increased malignant risk
True - Abdominal, Inguinal, Suprascrotal
Ectopic - perpenile, suberficial ectopic, transverse scrotal, femoral, perineal
Term
Transabdominal Phase
(descent of testis)
Definition
Mullerian inhibitin substance
Term
Inguinoscrotal phase
(testis descent)
Definition
Androgen induced release of calcitonin-gene related pepitde

Failure here 90-95% of cases
Term
Orchitis
Definition
Inflammation of the testes
Bacterial - epididymitis (syphilis)
Viral - (mumps)
Term
Epidiymitis
Definition
Adults
N. gonorrhea, C Trachomatis, E. Coli, M. tuberbulosis
Term
Idiopathic Granulomatous Orchitis
Definition
Uncommon
Follows gram (-) UTI
5th and 6th decade
Intratubular cellular infiltrate - histocytes, lymphocytes, plasma cells
Distinct Granulomas NOT formed
Term
Testis Regression
(or atrophy)
Definition
VINDICATE

V- Vascular
I- Inflammation
N- Neoplasms
D- Degenerative
I- Intoxication
C- Congenital
A- Autoimmune
T- Trauma
E- Endocrine
Term
Germ Cell Tumors
Definition
Seminomas
Embryonal Carcinoma
Yolk sac tumomr
Choriocarcinoma
Teratoma
Term
Seminomas
Definition
Most Common
Painless enlargement
Distinct cell membrane and clear cytoplasm
"Fried Egg"
15% - HCG
Radiosensitive
Term
embryonal Carcinoma
Definition
2nd most common
commonly mixed
More aggressive than seminomas
Painful
Malignant
HCG increased
Term
Yolk Sac Tumor
Definition
Infants and Children up to 3 yo
AFP production
Schiller-Duval Bodies
Term
Choriocarcinoma
Definition
commonly in mixed tumors
Highly aggressive
Mimics Placenta histology
produces HCG
my present with gynecomastia
Very Vascular - Bleed easily
Term
Teratoma
Definition
Pure form- more common in children
Mixed in adults - rare
Cysts common
can become malignant
Term
Prostate- Nodular Hyperplasia
(Benign Prostatic Hyperplasia)
Definition
Urinary Tract Obstruction
Transitional and Periurethral Zones
Term
Prostate Adenocarcinoma
Definition
Rare <50yo
2nd most common cancer-related death in males
Posterior Lobe
Digital rectal exam
serum PSA elevated
Term
Prostate Carcinoma Metastases
Definition
Very Common
Osteoblastic (Not osteolytic)
Increased Alk Phosphate
May respond to Endocrine therapy
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