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mafouz
n/a
31
Pharmacology
Undergraduate 1
05/05/2014

Additional Pharmacology Flashcards

 


 

Cards

Term
isoniazid MOA
Definition
bactericidal and bacteriostatic
prodrug (activated by peroxidase) then inhibits mycolic acid biosynthesis
Term
isoniazid resistance
Definition
KatG and InhA mutations
Term
isoniazid ADE
Definition
peripheral neuropathy, CNS issues, rheumatic syndrome, anemia
Term
rifampin MOA
Definition
bactericidal
RNA polymerase inhibitor
Term
rifampin resistance
Definition
RNA polymerase mutations
Term
rifampin ADE
Definition
hepatotoxicity
red-orange fluids
Term
ethambutol MOA
Definition
bacteriostatic
arabinoxyl transferase (EmbB) inhibitor - cell wall biosynthesis inhibitor
Term
ethambutol resistance
Definition
EmbB mutations
Term
ethambutol ADE
Definition
optic neuritis, hyperurecimia, arthalgia
Term
pyrazinamide MOA
Definition
bactericidal
prodrug (activated by pyrazinamidase) then acidification of cytoplasm
Term
pyrazinamide resistance
Definition
pyrazinamidase mutations
Term
pyrazinamide ADE
Definition
hepatotoxicity, arthritis
Term
aminoglycoside MOA
Definition
bactericidal
irreversible binding to 30S subunit of ribosome
Term
aminoglycoside resistance
Definition
dutations in ribosomes or rRNA
Term
aminoglycoside ADE
Definition
ototoxicity
nephrotoxicity
Term
fluoroquinolones MOA
Definition
bactericidal
DNA gyrase inhibitor
Term
fluoroquinolones resistance
Definition
DNA gyrase mutations
efflux pumps
Term
fluoroquinolones ADE
Definition
GI issues
vent. tachy.
Term
d-cycloserine MOA
Definition
bactericidal
d-alanine racemase and d-alanine d-alanine ligase inhibitor
Term
d-cycloserine resistance
Definition
mutations in target enzymes
Term
d-cycloserine ADE
Definition
CNS and psychiatric
Term
ethionamide MOA
Definition
bacteriostatic
prodrug (activaed by monooxygenase EtaA) then InhA inhibitors
Term
ethionamide resistance
Definition
EtaA or InhA mutations
Term
ethionamide ADE
Definition
GI issues, hepatotoxicity
Term
cyclic peptide MOA
Definition
30S subunit interference
Term
cyclic peptides resistance
Definition
identified with aminoglycosides
Term
cyclic peptides ADE
Definition
aminoglycosides
Term
p-aminosalicylic acid MOA
Definition
bacteriostatic
folic acid synthesis inhibitor
Term
p-aminosalicylic acid ADE
Definition
GI issues, hepatitis, anemia
Term
bedaquiline MOA
Definition
ATP synthase inhibitor
Term
bedaquiline ADE
Definition
nausea
QT prolongation
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