Term
| What are some risk factors for Hodkin's disease? |
|
Definition
1) Males
2) 10x risk w/ same sex sibling |
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|
Term
| What is considered to be the malignant cell of Hodkin's disease? |
|
Definition
| Reed-Sternberg cell, a multinucleate giant cell |
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Term
| 4 subtypes of Hodkin's disease and most common one? |
|
Definition
1) Lymphocyte predominance
2) Nodular Sclerosis - most common
3) Mixed Cellularity
4) Lymphocyte depletion |
|
|
Term
| 4 subtypes of Hodkin's disease and most common one? |
|
Definition
1) Lymphocyte predominance
2) Nodular Sclerosis - most common
3) Mixed Cellularity
4) Lymphocyte depletion |
|
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Term
| What is the most common presenting clinical feature of Hodkin's disease? |
|
Definition
| painless lymph node enlargement |
|
|
Term
| What are the first signs of subdiaphragmatic disease in Hodkin's disease? |
|
Definition
| Spleen and lymph nodes in the celiac axis |
|
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Term
| Who are more likely to have widespread disease with a worse prognosis? |
|
Definition
1) HIV infected
2) Elderly
3) developing countries |
|
|
Term
| What is essential for diagnosis in Hodkin's disease? |
|
Definition
|
|
Term
| What is the tool of choice for diagnosing occult spleen enlargement in Hodgkin's disease? |
|
Definition
|
|
Term
| Staging and prognosis for Hodgkin's disease |
|
Definition
stage 1-single LN involvement
stage 2-involvement of 2 or more LN regions on the same side of the diaphragm
stage 3-involvement of LN on both sides of diaphragm
stage 4-Involvement of one more extranodal sites |
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|
Term
| What is used to treat Hodgkin's disease in most cases? |
|
Definition
|
|
Term
| What is the single most important test for diagnosing Non-hodgkin's lymphoma? |
|
Definition
| properly evaluated and technically adequate biopsy |
|
|
Term
| What are 5 adverse risk factors for prognosis in Non-hodgkin's lymphoma? |
|
Definition
1) Age >60
2) Stage III/IV disase
3) 2 or more extranodal sites
4) performance status >2
5) increased LDH |
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