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Lymphomas & Leukemias
Hodgkins, Non-Hodgkin, AML, ALL, CML, CLL
34
Biology
Graduate
05/23/2012

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Cards

Term
EBV
Definition
Burkitts (Non hodgkins)
Term
c-myc
Definition
Burkitts (Non hodgkins) - Transcription activator Gain of function
Term
t (8;14)
Definition
Burkitts (Non hodgkins)
Term
Non hodgkins lymphoma type present in adolescents
Definition
Burkitts (Non hodgkins)
Term
bcl-2
Definition
Follicular (Non hodgkins ) - Anti Apoptotic gene Gain of function
Term
t (14,18)
Definition
Follicular (Non hodgkins )
Term
CD 5 +
Definition
Mantle Cell (Non hodgkins), CLL. - These 2 are B cells but end up having CD 5
Term
Cyclin D
Definition
Mantle Cell (Non hodgkins) - G1->S transition promoter gain of function
Term
t (11,14)
Definition
Mantle Cell (Non hodgkins)
Term
Non hodgkins lymphoma type present in Old ppl
Definition
Mantle Cell, Diffuse large B cell
Term
Biggest lymph nodes of all Lymphomas
Definition
Diffuse large B cell (Non hodgkins)
Term
Lymphoma ass. with Cutaneous & Bone lesions
Definition
Adult T-Cell (HTLV-1) (Non hodgkins)
Term
CD 4 +
Definition
Mycosis fungoides (Sezaray) (Non hodgkins)
Term
Lymphoma ass. with Cutaneous lesions
Definition
Adult T cell(HTLV-1), Mycosis Fungoides(Sezaray) - The only T cell ones (besides ALL)
Term
TdT +
Definition
ALL - Marker for Pre(immature) T & B cells
Term
CALLA +
Definition
ALL
Term
t (12;21)
Definition
ALL - having this mutation = good outcome
Term
Leukemia: age <15
Definition
ALL
Term
Smudge cells
Definition
CLL - fragile B cells break when spread onto slide
Term
Warm Antibodies
Definition
CLL
Term
deletion
Definition
CLL
Term
Leukemia: age >60
Definition
CLL
Term
Hair like projections on cells
Definition
Hairy Cell leukemia
Term
TRAP
Definition
Hairy Cell leukemia - tartrate resistant acid phosphatase
Term
Auer Rods
Definition
AML - Needle shaped granules filled with lysosomal & perixisomal material that can cause DIC if released
Term
Treat with Vit A
Definition
AML
Term
t (15;17)
Definition
AML
Term
Leukemia: Age 15-60
Definition
AML
Term
bcr-abl
Definition
CML - Tyrosine kinase gain of function
Term
t (9;22)
Definition
CML - Philadelphia ( this mutation can be present in other leukemia/lymphoma types. Always means bad prognosis.
Term
Leukemia: Age 40-60
Definition
CML
Term
CD 15 +
Definition
Hodgkins (Reed sternberg B cells)
Term
CD 30 +
Definition
Hodgkins (Reed sternberg B cells)
Term
CD 23
Definition
Mantle cell
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