Term
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Definition
| 2 Types: Non-Hodgkin's Lymphoma, and Hodgkins' Lymphoma |
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Term
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Definition
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Term
| Small Lymphocytic Lymphoma (SLL) |
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Definition
Type of Non-Hodgkin's Lymphoma
Tissue form of CLL
Lymphadenopathies
10-year survival time
Has small lymphoid cells with course chromatin, inconspicuous nucleoli, scanty cytoplasm
Smudge cells
Bone marrow shows nodular, diffuse, or interstitial infiltrations of the small lymphoid cells
WHO classifies this as CLL |
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Term
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Definition
Type of Non-Hodgkin's Lymphoma
Originates from germal centers
Has numerous, closely-spaced follicles that replace the normal architecture
Medium-sized lymphoid cells with angular or indented nuclei
Found in people aged 50-60
Most common |
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Term
| Mantel Cell Lymphoma (MCL) |
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Definition
Type of Non-Hodgkin's Lymphoma
Found in 60-year old men
No large cell component
Medium-sized lymphoid cells with irregular nuclear outlines
Main site of involvement is the lymph nodes
People live 3-5 years
Poor response to therapy
CD19, CD5, FMC-7, slg |
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Term
| Mucosal-Associated Lymphoid Tissue Lymphoma (MALT) |
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Definition
Type of Non-Hodgkin's Lymphoma
Has lympho-epithelial lesions that infiltrate with the neoplastic lymphocytes
Preceede inflammtory disorders such as Heliobacter pylori, Sjorins, and Hashimotos
-Go away if these are untreated
3 Types: Nodal, Extranodal, and Splenic |
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Term
| Waldenstrom's Macroglobulinemia |
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Definition
Type of Non-Hodgkin's Lymphoma
Lymphoid malignancy that causes an increased production of monoclonal IgM
Symptoms include lymphadenopathies, hepatomegally, splenomegally, and hyperviscous syndrome
No bone lesions
Treatment involves plasmaphoresis
Most patients live for 4 years |
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Term
| Diffuse Large B-Cell Lymphoma (DLBCL) |
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Definition
Type of Non-Hodgkin's Lymphoma
Diffuse proliferation of large lymphoid cells that replace the lymph architecture and have single or multiple nucleoli
Usually found in 60-year-olds
Localized disease
Aggressive
Sensitive to multi-agent chemotherapy |
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Term
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Definition
Type of Non-Hodgkin's Lymphoma
High-grade
High incidence in Africa
Found outside Africa in people with compromised immune systems (such as HIV)
Biopsy reveals a Starry Sky appearance
-Sky = Blue nucleoli of the neoplastic lymphocytes
-Star = Scattered, pale-staining macrophages
t(8;14) distinguishes this from DLBCL
Treatment involves aggressive chemotherapy
May see epstein-barr as well |
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Term
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Definition
Type of Non-Hodgkin's Lymphoma
Tissue equivalent of ALL
Usually seen in children
80% are T-cell in origin
Positive TdT |
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Term
| Peripheral T/NK-Cell Lymphoma |
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Definition
Type of Non-Hodgkin's Lymphoma
Either have a mature T-cell or a mature NK-cell
Associated with post-epstein-barr infections
Very aggressive
CD30
Seen in pediatric patients |
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Term
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Definition
| 2 Broad Categories: Nodular Lymphomas and Classic Hodgkin's |
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Term
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Definition
Type of Hodgkin's Lymphoma
The B-cells are the neoplastic cells |
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Term
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Definition
Type of Hodgkin's Lymphoma
Reed-Sternburg Cells |
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Term
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Definition
A type of tumor cells
2+ nuclear lobes
Have inclusions that look like nucleoli
Have an area of nuclear clearing that looks like an owl's eyes |
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