Term
| Chronic Leukemic Lymphoid Malignancies |
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Definition
Grouped together because the malignant cells are mature lymphs
Primary located in the blood and bone marrow
7 Types |
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Term
| B-Cell Chronic Lymphocytic Leukemia |
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Definition
Usually happens in older men
Usually asympomatic
Lymphocytes are small with scanty cytoplasm
-Ginger Snaps
- >5 x 10^9
<10% prolymphocytes
Smudge Cells
CD5, CD19, CD23 with surface IgG
Anemia
Thrombocytopenia
Neutropenia
Low grade
20% of patients develop Richter's Transformation |
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Term
| Prolymphocytic Leukemia (PLL) |
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Definition
Aggressive leukemic disorder
2 Types: T-Cell and B-Cell |
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Term
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Definition
Symptoms include splenomegally, skin lesions, and lymphadenopathies
Increased lymphocyte count with varied appearances
CD2, CD5, CD7
Inv(14)q11q32
Anti-CD52 Monoclonal Antibody Therapy
Most patients live 7.5 months |
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Term
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Definition
Usually found in adults males
Increased lymphocytosis (>300 x 10^9)
-55% are prolymphocytes
Anemia
Decreased platelets
CD20, FMC-7 with strong surface immunoglobulin
Does not take well to treatment |
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Term
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Definition
Uncommon B-cell leukemia
Found in middle-aged people, mostly males
Lymphocytes with hairy projections, oval nuclei, and fine chromatin
Pancytopenia
Massive Splenomegally
TRAP Positive
CD19, CD20, CD22, CD11c, CD25 with strong surface immunoglobulin
Bone marrow shows in increase in abnormal lymphocytes that look like "fried eggs"
Dry Taps due to increased cytokines
Treatment involves 2-chloro-deoxyadenosine, deoxycoformycine, a-interferons, and purine analogs |
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Term
| Large Granular Lymphocytic Leukemia (LGLL) |
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Definition
| 2 Types: T-Cell and Natural Killer Cell |
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Term
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Definition
Pancytopenia
Lymphocytes have abundant pale-staining cytoplasm with azurophilic granules and positive rheumatoid factor
CD2, CD3, CD8, CD16, CD56, CD57
T-cell receptors are clonally rearranged
Indolent course
80% of patients live 10 years |
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Term
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Definition
More acute presentation
Very aggressive
Decreased WBC's and RBC's
CD2, CD3, CD8, CD4, CD16, CD56, and CD57
T-cell receptors are not rearranged
Rapidly fatal |
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Term
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Definition
Has malignant lymphocytes with regular, convoluted nuclear outlines and fine chromatin
Cutaneous T-cell leukemia
Slow progression
Treatment is localized |
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Term
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Definition
| Lymphocytes with hairy projections, oval nuclei, and fine chromatin |
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Term
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Definition
| Malignant lymphocytes with regular, convoluted nuclear outlines and fine chromatin |
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