Shared Flashcard Set

Details

Lung Cancer
Pulmonary Module
28
Medical
Graduate
10/22/2009

Additional Medical Flashcards

 


 

Cards

Term
What type of lung cancers is pancoast syndrome most seen in?
Definition
non-small cell
Term
What four main symptoms are found in pancoast syndrome?
Definition

brachial plexus involvment

rib pain

horner's syndrome

anhidrosis (lack of sweating)

Term
What is the paraneoplastic sign found in squamous cell carcinoma?
Definition
hypercalcemia
Term
What lung cancer type is cushing syndrome seen in?
Definition
small cell
Term
What lung cancer type is Lambert-eaton seen in?
Definition
small cell carcinoma
Term
If a new incidental nodule is found on XRAY and is less than 1 cm, what must be done next?
Definition
look at old xray and if nothing found on old xray follow up in 6-12 months
Term
What is limited small cell carcinoma?
Definition
carcinoma within the thorax
Term
Which form of small cell carcinoma is curable with chemoradiation?
Definition
limited
Term
What is the treatment goal for extensive small cell carcinoma?
Definition
pallative chemo
Term
Why do you not screen for lung cancer?
Definition
because it tends to overdiagnois and cant detect the slow growers
Term
Under what conditions do PET scans lead to false - in lung cancer staging? (3)
Definition

hyperglycemia

low metabolic tumors

when the tumor is below threshold that it can see

Term
Under what conditions can PET scans lead to false positive in staging?
Definition
TB, sarcoidosis and fungi
Term
What stages of non-small cell carcinoma are treated with surgery with a goal of cure?
Definition
I and II
Term
Under what extenuating circumstance do you still do surgery when you have a stage IV lung cancer?
Definition
when it is T1-2/N0 with brain mets
Term
In stage IIIb what do you do prior to surgery for better chance of cure?
Definition
chemoradiation to shrink the tumor before removing it
Term
What is done for stage IV non small cell carcinoma patients?
Definition
pallative care with chemo to improve survival and quality of life
Term
What does performance status measure and what is the general scale?
Definition

measures potential response to surgery

3 or greater poor response

 

0 no limitation, asymptomatic

3 >50% time in bed

4>100% in bed

5 dead

Term
How many chemo drugs is best?
Definition
two better than one and three
Term
What does VEGF modulate?
Definition
angiogenesis
Term
What drug is a monoclonal antibody against VEGF?
Definition
Bevacizumab
Term
What cancer type can Bevacizumab not be used for and why?
Definition
squamous carcinoma b/c associated with major hemorrhage
Term
What are two important adverse effects of bevacizumab?
Definition

HTN

Hypersensitivity

Term
What is Erlotib?
Definition
a drug against the EGF-R
Term
What is Erlotib used in?
Definition
non small cell carcinoma
Term

Which cancer drug do you want to combine with chemotherapy to get proven benefit?

 

Bevacizumab or Erlotib

Definition
Bevacizumab
Term
What are two side effects of Erlotib?
Definition

rash

diarrhea

Term
What are 4 clinical manifestations of vena cava syndrome?
Definition

headache

venous distention

SOB

swelling of the face

Term
If you highly suspect lung cancer and both chest xray and CT are negative, what is the next best test?
Definition
bronchoscope
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