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Lower Urinary Tract
Path Assesment 12
15
Pathology
Graduate
01/26/2012

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Cards

Term
Transitional Epithelium
Definition
Unique to Lower Urinary tract
Superficial Layer - umbrella cells
Intermediate layer - 1-5 cells thick
Basal Layer - small cells, 1 cell thick
Term
Ureteropelvic Junction obsturction
Definition
Excess stromal deposition of collagen between smooth muscle bundles
Hydronephrosis
More common in Boys
Term
Intrinsic Causes of Ureter Obstruction
Definition
Calculi
Strictures
Neoplasms
Blood Clots
Neurogenic causes
Vesicoureteral reflux
Term
Extrinsic causes of Ureter Obstruction
Definition
Pregnancy
Periureteral Inflammation
Ureteral Inflammation
Endometriosis
Neoplasms
Term
Calculi
(three points of narrowing)
Definition
Intrinsic Obstruction
Colicy Pain
Three Points of Narrowing:
1. Ureteropelvic Junction
2. Ureters Cross iliac vessels
3. Ureters enter bladder
Term
Strictures
Definition
Chronic inflammation or sclerosing retroperitoneal fibrosis
Term
Benign Primary Tumors of Ureters
Definition
Fibroepithelial Polyps
Leiomyomas
Term
Primary Malignant Tumors of Ureters
Definition
Transitional Cell Carcinoma
Term
Cystocele
Definition
Protrusion of Bladder into Vagina
Leads to Uterine Prolapse
Term
Cystitis
Definition
E.Coli (most common), proteus...
Increased frequency, lower abdominal pain, dyrusia
Fever, Chills, malaise
Acute: Neutrophils
Chronic: lymphocytes, plasma cells, macrophages
Term
Malakoplakia
Definition
Chronic E.Coli infection of Bladder
soft, yellow, mucosal plaques
Foamy macrophages - PAS + granules
Michaelis-Gutmann Bodies
Defective Host Response to E.coli
Term
Interstitial Cystitis
Definition
Suprapubic Pain
Urinary frequency, urgency
Hematuria
Dysuria
No Evidence of Bacterial Infection
Inflammation and Fibrosis of all layers of Bladder wall
maybe autoimmune
Term
Urothelial (Transitional cell) Tumors
Transitional Cell Carcinoma
Definition
Men>Women
Lateral or posterior walls at base of bladder
Reoccur after removal
Papillary - lower grade
Flat - Higher grade
Painless hematuria
Higher the Grade Higher chance of recurrence
Term
Transitional cell carcinoma in situ
Definition
Disorganized
Pleomorphic cells
hyperchromatic nuclei
prominent nucleoli
numerous mitotic figures
Term
Squamous Cell Carcinoma of Bladder
Definition
Schistosomiasis
fungating and invasive
Chronic Bladder irritation-> dysplasia + SCC
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