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Lorenz Summary Notes
Neuro Exam
158
Veterinary Medicine
Professional
11/21/2014

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Cards

Term
Definition: Paresis
Definition
-partial loss of muscle function caused by deficits in motor function
Term
Definition: Paralysis
Definition
-total loss of muscle function caused by deficits in motor function
Term
Definition; Ataxia
Definition
-loss of coordination
Term
Definition: Proprioception
Definition
-position sense
Term
Definition: Pain
Definition
-the conscious perception of noxious stimuli
Term
Definition: Analgesia
Definition
-reduced perception of noxiuous stimuli (pain)
Term
Definition: Paraesthesia
Definition
-altered sensory perception
Term
Definition: Hyperesthesia
Definition
-increased sensitivity to non-painful stimulli
Term
Definition: Upper Motor Neurons (UMN)
Definition
-part of the motor system with both neurons and axons confined to CNS
Term
Definition: Lower Motor Neuron (LMN)
Definition
-part of the motor system with neurons located in CNS and axons form the peripheral NS
Term
Definition: Efferent
Definition
-away from the brain, usually refers to motor pathways
Term
Definition: Afferent
Definition
-towards the brain, usually refers to sensory pathways
Term
Definition: Forebrain
Definition
-cerebrum plus the diencephalon
Term
Definition: Midbrain
Definition
-midbrain
Term
Definition: Hindbrain
Definition
-pons, medulla, and cerebellum
Term
Definition: Postural reaction
Definition
-tests that involve sensory and motor function and require coordination in the cerebral cortex
Term
Definition: Reflex
Definition
-actions that occur below the level of consciousness
Term
True or False: Not all reflexes have sensory and motor components
Definition
FALSE; ALL reflexes have sensory and motor components THUS are found in both somatic and autonomic nervous systems
Term
Definition: Somatic Nervous System
Definition
-the nn that supply the body wall and limb as opposed to the viscera
Term
Definition: Autonomic Nervous System
Definition
-composed of sympathetic and parasympathetic components
-regulate many visceral functions below the level of consciousness such as repiration, HR, digestion, and many glandural functions
Term
Definition: Nuclei
Definition
-aggregations of neurons within the CNS that share similar functions
ex: vestibular nuclei located in the rostral medulla
Term
Definition: Ganglia
Definition
-aggregations of neurons located outsidethe CNS that share similar functions
-ex: dorsal root ganglia located outside the spinal cord and contain the neurons of sensory peripheral nn
Term
Give a few examples of defects in the development of the NS
Definition
-hydrocephalus
-spina bifida
-cerebellar hypoplasia
Term
What are the 3 embryonic germ cell layers?
Definition
-ectoderm, mesoderm, and endoderm
Term
The nervous system is derived from ________ and is specifically called _________.
Definition
-ectoderm
-neuroexctoderm
Term
The process by which the nervous system develops from the ectoderm is called what? When in development does it begin?
Definition
-neurulation
-3rd week of fetal life
Term
The vertebra, skull, and muscle are derived from which derm layer?
Definition
-mesoderm
Term
What are the steps of the development of the nervous system?
Definition
-Step 1: formation of the neural plate
-step 2: differentiation of neural plate into the neural tube, the neural tube closes in early embryonic development
-Step 3: neural tube differentiates into the brain and spinal cord; the lumen of the neural tue becomes the ventricles of the brain and the central canal of the spinal cord
-Step 4: formation of the neural crest, neural crest cells are derived from the neural plate (neural crest cells migrate to many sites in the body and they create most components of the peripheral and autonomic NS)
Term
Give some examples of defects in neural tube development?
Definition
-Dysraphism (abnormal seam or suture): common defects in bulldogs and manx cats
-Anencaphaly: absence of cerebral hemisphers
-Spina bifida: failure to close the certebral arch; often associated with spinal dysraphism
Term
What are the components of the peripheral and autonomic NS?
Definition
-peripheral nn
-peripheral cells of the autonomic SN
-ganglia
-Schwann cells: cell that make myelin
-Pigment cells of the skin (melanocytes)
Term
_________ creates the skeleton that surrounds and protects the CNS
Definition
-mesoderm
Term
What are the 3 components of the nervous sytem?
Definition
-peripheral NS
-central NS
-autonomic
Term
What are the components of the CNS?
Definition
-brain and spinal cord
Term
What are the components of the PNS?
Definition
-peripheral and cranial nn
Term
True or False: The autonomic NS contains broth central and peripheral components.
Definition
TRUE
Term
What are the major divisions of the brain?
Definition
-cerebrum
-cerebellum
-brain stem
Term
What are the functions of the cerebrum?
Definition
-cognitive functions, consciuous perception of sensory information (visio, hearing, noxious stimuli, and peoprioception), behavior and motor activates
-DOES NOT MAINTAIN GAIT IN QUADRUPEDS
Term
What are functions of the frontal lobes?
Definition
-motor and behavioral functions
Term
What are the functions of the temporal lobe?
Definition
-hearing, proprioception, and other sensory functions
Term
What are the functions of the parietal lobe?
Definition
-touch, pain, pressure, temperature, position sense, and noxious stimuli
Term
What is the function of the occipital lobe?
Definition
-vision
Term
True or False: sensory information is generally projected to the contralateral cerebral hemisphere while motor impulses are projected to the contralateral limbs.
Definition
TRUE
Term
What are the components of the brain stem?
Definition
-diencephalon, midbrain, pons, and medulla
Term
Note: The brainstem contains cranial nerve nuclei, centers that initiate motor activity, vestibular centers, and both sensory and motor long tracts.
Definition
Term
True or False: Motor centers in the brainstem maintain gait in quadrupeds.
Definition
TRUE
Term
What are the components of the diencephalon? Functions?
Definition
-Thalamus: major center for relaying sensory information to the cerebrum
-Hypothalamus: ventral to thalamus; involved with endocrine and autonomic functions
-CNII: Optic n just rostral to thalamus
Term
What are the components of the Midbrain? Functions?
Definition
-CNIII (Occulomotor): controls movement of the eyeball and pupillary constriction in response to light
-Somatic motor functions
Term
True or False: Lesions rostral to the midbrain cause neurological deficits in the ipsilateral limbs and lesions caudal to the midbrain cause contralateral deficits.
Definition
FALSE, lesions rostral to the midbrain cause ceurological deficits in the contralateral limbs, and lesions caudal to the midbrain cause ipsilateral deficits
Term
What are the clinical signs of midbrain disease?
Definition
-paresis, ataxia, and ventro-lateral strabismus and PLR deficits in the eye ipislateral to the lesion
Term
What are the functions of the pons?
Definition
-area where motor and sensory information flows to and from the cerebellum
-has centers for motor function and contains the centers for the micturition
Term
What are the clinical signs of a lesion in the pons?
Definition
-ataxia, paresis, and cranial nerve dysfunction
CLINICAL SIGNS ARE IPSILATERAL TO THE LESION
Term
What are the components of the medulla? Functions?
Definition
-CN 5-12
-contains motor, vestibular, vomiting, and cardiopulmonary centers
Term
What are the clinical signs of a lesion in the medulla?
Definition
-depression, paresis, ataxia, vestibular, and cranial nerve dysfunction
CLINICAL SIGNS ARE IPSILATERAL TO THE LESION
Term
What are the functions of the cerebellum?
Definition
-coordinates and regulates motor activity initiated in other parts of the brain
-gets sensory input from all areas of the boyd (vision, general proprioception, an dvestibular inputs)
Term
Lesions in the cerebellum may cause the syndrome of _________ vestibular disease.
Definition
-paradoxical
Term
What are the major clinical signs of cerebellar disease?
Definition
-severe symmetrical ataxia of the limbs of the body
NO PARESIS OR DEPRESSION IN PURE CEREBELLAR DISEASE
Term
True or false: Developmental defects in the cerebellum are common and can be inherited or caused by infectious viral agents that affect the cerebellum during embryonic development.
Definition
TRUE
Term
What are the components of the forebrain?
Definition
-cerebrum and diencephalon
Term
What are the major clinical signs of a lesion in the forebrain?
Definition
-seizures
-depression, dementia
-circling towards the side of the lesion
-aimless wandering and head pressing
-blindness, decreased menace response in contralateral eye
-decreased perception of noxious stimuli
-postural deficits in contralateral limbs
-little to no gait abnormality
-endocrine dysfunction
Term
What are the components of the hindbrain?
Definition
pons, medulla, and cerebellum
Term
The spinal cord is composed of ________ and ________ axons or long tracts (white matter peripherally) and both ________ and ________ neurons (gray matter centrally).
Definition
-motor and sensory axons
-sensory and motor neurons
Term
Definition: Spinal cord segment
Definition
-that area bonded by a pair of spinal nn located on each side of the spinal cord
Term
Each spinal nerve has a dorsal root which is strictly ______ and a ventral root that is strictly _________.
Hint: sensory or motor
Definition
-sensory
-motor
Term
The dorsal root ganglion contains the nerve cell bodies of what kinds of nerves?
Definition
-sensory
Term
Where are motor nerve cell bodies located? What is another term for them?
Definition
-ventral lateral gray matter
-called lower motor neurons
Term
True or False: The dorsal horns contain neurons for the integration f sensory information. They interact with LMN to initiate spinal reflexes or can relay info via sensory long tracts to the brain.
Definition
TRUE
Term
What are the division of the canine spinal cord? How many vertebrae are in each segment?
Definition
-Cervical: 8
-Thoracic: 13
-Lumbar: 7
-Sacral: 3
-Coccygeal: 5
Term
What spinal cord segments innervate the TL? What is the term for this segment?
Definition
-C6-T2
-Brachial Plexus
Term
What spinal cord segments innervate the PL? What is the term for this segment?
Definition
-L3-S2
-Lumbosacral olexus
Term
How can nerves be generally evaluated?
Definition
-testing postural reactions, spinal reflexes, and sensation to various parts of the limb
Term
The outer region of the spinal cord is (white/gray) matter composed of _______ organized into spinal pathways or tracts.
Definition
-white
-myelinated axons
Term
The ascending pathways are primarily (sensory/motor) and carry information to the brain. Examples?
Definition
-sensory
-pain, touch, pressure, temperature, and proprioception
Term
The descending pathways transmit both _______ (somatic) and ______ (autonomic) (sensory/motor) information from centers in the cerebrum and brainstem. What is the other term for these neurons?
Definition
-voluntary
-involuntary
-motor
-UMN
Term
The core of the spinal cord is composed of (gray/white) matter.
Definition
gray
Term
the ventral gray matter contains the (motor/sensory) neurons whose axons innervate _______. These are called what?
Definition
-motor
-somatic mm
-LMN
Term
LMS innervate _______ and are the motor component of _____.
Definition
-muscle and glands
-reflexes
Term
Neurons in the dorsal gray matter are responsible for what?
Definition
-integrating sensory information and relaying information to other areas of the spinal cord
Term
True or False: All reflexes have a sensory and a motor component and are involuntary.
Definition
TRUE
Term
Give 2 examples of spinal reflexes
Definition
-Extensor: knee jerk or patellar reflex
-Flexor: withdrawal reflex
Term
Outline the descending pathways in the spinal cord. What are these neurons called?
Definition
neurons in brain=> axons travel down spinal cord=> initiate motor actions
-called Upper Motor Neurons
Term
The ventral grey matter of the spinal cord contains the motor neurons whose axons innervate _________. These neurons are called ________.
Definition
-somatic mm
-LMN
Term
True or false: UMNs are the motor component of reflexes.
Definition
FALSE, LMN are the motor component of reflexes.
Term
What are the neurons in the dorsal grey matter responsible for?
Definition
-integrating sensory information and relaying information to oher areas of the spinal cord
Term
All reflexes have a (sensory/motor/both) component and are (voluntary/involuntary).
Definition
-both
-involuntary
Term
What are the two most important types of spinal reflexes?
Definition
-withdrawal reflex
-extensor/ knee jerk/ patellar reflex
Term
Outline the pathway of a spinal reflex
Definition
noxious timulus=> transmitted to spinal cord via peripheral nn=> enters via dorsal root=> synapses on interneurons=> on ipsilateral sie, stim flexor mm and inh extensor mm=> animal moves away from the nixous stimulus and prevents injury
Term
Are spinal reflexes contralateral or ipsilateral?
Definition
-ipsilateral
Term
Definition: Crossed Extensor Reflex
Definition
-during the stimulation of a spinal nerve, in the ipsilateral side flexors will be stim and extensors are inh THUS this reflex is when on the contralateral side, extensor mm stim and flexor mm inh
Term
In the PL, what nerve does the withdrawal reflex test? TL?
Definition
-sciatic
-several, mostly radial and musculocutaneous in brachial plexus
Term
What is the most reliable extensor reflex? Is it monosynaptic or polysynaptic? Which nerve does it test?
Definition
-patellar or knee jerk reflex
-monosynaptic
-femoral nerve
Term
the Peripheral Nervous System (PNS) is composed of what nerves?
Definition
-cranial nen
-nn that innervate the trunk and limbs
Term
True or False: Peripheral nn contain motor and sensory fibers but no autonomic fibers.
Definition
FALSE, contains motor, sensory, and autonomic fibers
Term
Definition and test: CNI
Definition
-Olfactory n
-senses smell, no motor
-test response to odors
Term
Definition and test: CNII
Definition
-Optic n
-senses sight, no motor
-test via menace
Term
Definition and test: CNIII
Definition
-Oculomotor n
-no sensory, motor is eyeball movement, PLR
-test via conjugate eye, PLRs (constriction)
Term
Definition and test: CNIV
Definition
-Trochlear n
-no sensory, mtoor is dorsal oblique eye movement
-no tests
Term
Definition and test: CNV
Definition
-Trigeminal n
-sensory to face and mandible AND motor to mm of mastication
-test via palpebral reflex
Term
Definition and test: CNVI
Definition
-Abducent n
-no sensory, motor is lateral oblique and retractor oculi mm
-test via conjugate eye
Term
Definition and test: CNVII
Definition
-Facial n
-sensory to inner ear canal/taste AND motor to mm of facial expression
-test via palpebral reflex
Term
Definition and test: CNVIII
Definition
-Vestibulocochlear n
-sensory for hearing and balance; no motor
-test via neuroexam
Term
Definition and test: CNIX
Definition
-Glossopharyngeal n
-sensory to pharynx AND motor to pharynx (swallowing)
-test via gag reflex
Term
Definition and test: CNX
Definition
-vagus n
-sensory to viscera AND motor to mm of viscera
-test via gag reflex
Term
Definition and test: CNXI
Definition
-Spinal accessory n
-no sensory, motor to trapezius m
-no test
Term
Definition and test: CNXII
Definition
-Hypoglossal n
-no sensory, motor to tongue mm
-no test
Term
What are the systems most evaluated in neurology for motor, sensory, and special sensory?
Definition
-Motor: general somatic efferent system
-Sensory: general somatic afferent: Proprioception, touch, pressure, temperature, and pain
-Special sensory: special visceral afferent: vision, hearing, taste, vestibular
Term
The motor efferent system is composed of neuronal centers located in the _______ called (UMN/LMN) and neurons located in the _______ _______ and ______ called (UMN/LMN).
Definition
-brain
-UMN
-spinal chord
-brainstem
-LMN
Term
UMNs are located where? What do they do?
Definition
-brainstem and cerebral cortex
-initiate voluntary motor activity and produce their action via connections via LMNs
Term
True or False: UMNs have only facilitory actions on the LMNs which help regulate motor activities such as gait.
Definition
FALSE; have both facilitory and inhibitory actions
Term
What are the 2 major UMN pathways in animals?
Definition
-Pyramidal
-extra-pyramidal
Term
Outline the Pyramidal UMN System
Definition
-frontal cortex=> axons cross at pyramids in caudal medulla=> course on ipsilateral side=> to limbs
Term
Outline the Extra-pyramidal UMN System
Definition
-brainstem=> axons cross near midbrain=> go down to limbs
Term
Is the pyramidal or extra-pyramidal UMN system more important in quadrupeds? Why?
Definition
-extra-pyramidal
-quadrupeds are brainstem walkers, thus the UMN centers that control gait are located in the brainstem
Term
What are the clinical signs of lesions affecting the extra-pyramidal system?
Definition
-cause gait and postural rxn deficits in the ipsilateral limbs
Term
What motor functions does the cerebral cortex control? What test are useful to check it?
Definition
-NOT GAIT, involved in performining learned responses
-test= hopping, placing, and paw righting.
Term
LMNs are found in the __________ and the neuron cell bodies are located in the _________.
Definition
-spinal cord (all segments)
-ventral grey matter
Term
Outline the path of LMNs.
Definition
ventral grey=> exit spinal cord as ventral nerve roots=> become peripheral nn (may also contain sensory axons)=> terminate at motor endplates of muscle fibers=> innervate muscle or glands
Term
True or False: All motor activity of the CNS is expressed via the UMN system. And thus necessary for reflex wactivity.
Definition
FALSE, via LMN system and UMN are not required for reflex b/c reflexesa re involuntary
Term
What is the major clinical sign of motor dysfunction regardless of UMN or LMN/
Definition
-paresis (partial dysfunction) or paralysis (complete dysfunction
Term
What are the clinical signs of UMN dysfunction? How does its location matter?
Definition
-evaluate by gait and postural rxns
-cause paresis/paralysis, normal to inc reflexes distal to lesion
-blow midbrain= severe gait abnormalities and signs in ipsilateral limbs
-above midbrain= minor gait abnormalities and postural deficits in contralateral limbs
Term
What are the clinical signs of LMN dysfunction? Are the contralateral or ipsilateral limbs affected?
Definition
-cause paresis/paralysis, reduced muscle tone, rapid neurogenic muscle atrophy, and dec or absent reflexes
-ipsilateral limbs
Term
True or False: If paresis only affects the hind limbs, you know it is a lesion caudal to the brachial plexus.
Definition
TRUE
Term
If a cat presents with hindlimb paresis and has normal or increase hindlimb reflexes, where is the lesion? If the reflexes are decreased? Is it UMN or LMN?
Definition
-inc/normal= T3-L2 and UMN
-dec= L3-S2 and LMN
Term
A dog presents with severe paresis of all limbs (tetraparesis. What are the CNS and PNS locations in which a lesion could occur to cause this sign?
Definition
-CNS: C1-5, C6-T2, brainstem
-PNS: generalized LMN disease
Term
What is the responsibility of the General Proprioception Pathway? Where are the receptors located?
Definition
-sense of position of body, limbs, and head
-receptors in tendons, joint capsules, and mm
Term
Outline the General Proprioception Pathway.
Definition
peripheral nn=> enter spinal cord via dorsal n root=> info integrated in dorsal grey matter=> relayed to cerebellum, brainstem, and cerebrum via long tracts.
Term
What is the major clinical signs of proprioceptive dysfunction?
Definition
-ataxia (deficits in limb/body coordination and posture)
Term
the dorsal column pathway involves the (unconscious/conscious) perception of ________. How is it tested?
Definition
-conscious
-proprioception
-tested by paw-righting test
Term
What are the clinical signs of a lesion in the dorsal column system? Ipsilateral or contralateral?
Definition
-foot dragging and mild ataxia
-near midbrain so lesions above midbrain are in contralateral and lesions below midbrain are in ipsilateral limbs
Term
What is the function of the spinocerebellar system? Ipsilateral or contralateral/
Definition
-transmit proprioceptive information to the cerebellum where it is used to coordinate motor activity
-ipsilateral
Term
What are the clinical signs of a lesion in the spinocerebellar system?
Definition
-severe ataxia with signs similar to cerebellar disease, but NO INTENTION TREMORS
Term
What is the responsibility of the sensory system? What are its two divisions?
Definition
-reflexes and conscious perception of noxious stimuli (pain)
-Superficial and deep
Term
Deep pain pathways are (bilateral/unilateral) and (unisynaptic/multisynaptic). the project info to (left/right/both) cerebral hemisphere(s).
Definition
-bilateral
-multisynaptic
-both
Term
Superficial pain pathways project largely to the (ipsilateral/contralateral) cerebral cortex.
Definition
-contralateral
Term
True or False: Lesions in the spinal cord must be unilateral and severe to abolish deep pain responses.
Definition
FALSE: bilateral
Term
True or False: The vestibular system has peripheral and central components.
Definition
TRUE
Term
Where are the central components of the vestibular system? The peripheral
Definition
-Central: located in the rostral medulla near the origins of the facial and trigeminal nn
-Peripheral: semi-circular canals in the inner ear and the vestibular n
Term
What is the sensory function of the vestibular system? Outline its pathway.
Definition
-detects the linear motion and angular acceleration of the head
-info enters cerebellar peduncles=> cerebellum=> follows vestibulospinal tract to transmit motor activity and powerful stimulation of extensor mm
Term
The vestibulospinal tracts are an important component of the antigravity system since they facilitate ________.
Definition
-extensor mm
Term
Motor impulses also travel cranially via the __________ to nuclei of nn innervating the extra-ocular eye mm ( CN III, IV, and VI) and is important for what functions?
Definition
-medial longitudinal fasciculus
-coordination of eye movements when the head turns.
Term
What is the normal response of the eye when the head turns? What happens when this is broken?
Definition
-vestibular/conjugate eye movements
-broken= eyes staying dixed when the ehad turns
Term
What are the clinical signs of vestibular disease? Peripheral vestibular disease? Central vestibular disease?
Definition
-asymmetrical ataxia, head tilt, circling, and falling towards the side of the lesion AND nystagmus to opposite side
-Peripheral= postural rxs are normal
-Central= postural rxns are depressed or absent
Term
What are the components of the neuroanatomy of the eye and what are their functions?
Definition
-retina: image and light scanner
-Optic n: carries fribers for vision and PLR
-Optic Chiasm: point at chich fibers criss
-Optic tract: carries fibers for vision and PLr
-Lateral geniculate body of the thalamus: fibers from optic tract synapse here on neurons that will project to the visual/occipital cortex
-Optic radiation: fibers that project to the occipital cortex
-Occipital cortex: area where the image is developed into a picture
-Midbrain centers for parasympathetic division of the oculomotor nn: PLR, fibers form one side project to both eyes via CNIII
Term
The digitalized information from the retinas is carried to the brain via what?
Definition
-optin nerves, optic chiasm, optic tracts, lateral geniculate nucleus of the thalamus, and optic radiation
Term
The image received by the retinas is developed in the _______. Are they projected to the ipsilateral or contralateral cortex?
Definition
-occipital cortex
-contralateral
Term
What is the primary test to test the visual response pathway?
Definition
-menace response test
Term
Outline the pathway for PLR.
Definition
fibers for PLR leave the optic tracts=> enter the midbrain=> synapse on the parasympathetic motor centers of oculomotor nn=> (synapses are bilateral)
Term
The parasympathetic fibers of the oculomotor n innervate the pupillary m causing it to (constrict/dilate).
Definition
-cosntrict
Term
Definition: Mydriasis
Definition
-dilation of the pupil due to lack of oculomotor innervation
Term
Definition: Direct PLR
Definition
-shine light in eye and that eye constricts
Term
Defiition: Indirect PLR
Definition
-shine light in eye and other eye constricts
Term
Definition: Aniscocoria
Definition
-pupils of unequal size
Term
What are the clinical signs of:
a) unilateral affected side
b) unilateral unaffected side
c) bilateral
d)visual pathways
e)PLR Pathways of affected side
f) PLR Pathways of unaffected side
g) Sympathetic n
Definition
a) ne menace response, normal pupil size, no direct PLR, no consensual PLR
b) pos menace response, normal pupil size, pos direct PLR, pos consensual PLR
c) neg menace response, dilated pupil size, no direct PLR, no consencual PLR
d) neg menace resp0onse, normal pupils, pos direct PLR, pos consensual PLR
e) pos menace response, dilated pupil on affected side, no direct PLR, ps consensual PLR
f) pos menace response, dilated pupil on affected side, os Pdirect PLR, no consensual PLR
g) pos menace resonse, pupil constricted on affected side, pos direct PLR, pos Pconsensual PLR
Term
What nn control eye movement?
Definition
-oculomotor, trochlear, and abducent
Term
Definition: conjugate eye movements
Definition
-eye movement is coordinated so that each eye moves in the same direction at the same speed
Term
Definition; Strabismus
Definition
-eyes that are directed in an abnormal direction
Term
What eye mm does the oculomotore n (CNIII) innervate? What are the clinical signs of a lesion here?
Definition
-all mm except lateral rectus, dorsal oblique, and retractor bulbi mm
-ventrolateral strabismus and eye cannot move medially or dorsally
Term
What eye mm does the trochlear n (CNIV) innervate? What are the clinical signs of a lesion here?
Definition
-dorsal oblique m
-minor abnormalities
Term
What eye mm does the abducent n(CNVI) innervate? What are the clinical signs of a lesion here?
Definition
-lateral rectus and retractor bulbi mm (lateral movement and retraction)
-medial strabismus and inability to move the eye laterally and rectract
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