Term
| Mech of Action for Local anesthetics |
|
Definition
|
|
Term
| what is the effect of protein binding on LA's |
|
Definition
| high protein binding prolongs duration of action |
|
|
Term
|
Definition
| they are weak bases, so they will not work in acidic tissues (infections,necrosis) |
|
|
Term
| relationship b/t pKa and onset |
|
Definition
|
|
Term
| affect on dosage and volume |
|
Definition
| increased volume and dosage increases duration and widespread effects |
|
|
Term
| what will the addition of vasoconstrictors do to the LAs |
|
Definition
increase duration of action
**EXCEPT bupivicaine, etidocaine** |
|
|
Term
| the order of loss of nerve function as you increase LA |
|
Definition
| Pain, temp, touch, pressure |
|
|
Term
|
Definition
speeds onset and prolongs duration of action
**too much will precipiate LA** |
|
|
Term
| toxicity of systemic effects |
|
Definition
| CNS excitiation followed by CNS/CV depression |
|
|
Term
| Acidosis decreases what in the patient |
|
Definition
|
|
Term
| What is the CNS toxicity in relation to CV |
|
Definition
| CNS at lower concentrations |
|
|
Term
| Which occurs first w/Lidocaine? |
|
Definition
|
|
Term
|
Definition
| equal concentration w/toxicity |
|
|
Term
| when reporting allergies, what must be taken into consideration |
|
Definition
| additives such as epinephrine. |
|
|
Term
| LA assoc w/ lumbosacral nerve irritation |
|
Definition
| Lidocaine or meipivacaine |
|
|
Term
| LA associated w/Cauda equina syndrome |
|
Definition
|
|
Term
| this treats bupivicaine toxicity and CNS toxicity |
|
Definition
|
|
Term
| what is procaine used for? |
|
Definition
| diagnose pain syndromes in chronic pain patients |
|
|
Term
| What is chloroprocaine used for |
|
Definition
|
|
Term
|
Definition
rapid spinal anesthesia
topical |
|
|
Term
|
Definition
rapid absorption and onset
potent vasoconstrictor and topical |
|
|
Term
|
Definition
slow and short
can cause **methemoglobin** |
|
|
Term
| what is lidocaine used for? |
|
Definition
nerve block
IV antiarrhytmic agent
IV analgesic |
|
|
Term
|
Definition
common dental anesthetic
NO OB use |
|
|
Term
|
Definition
greatest separation of sensory from motor block.
used in OB *walking epidural*
less hypotension than tetracaine |
|
|
Term
|
Definition
similar to bupivicaine
S isomer lowers cardiac toxicity |
|
|
Term
|
Definition
profound motor and sensory blockade
the most profound motor blockade: NO OB use |
|
|
