Term
Serpentine Cords
High lipid content in cell wall |
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Definition
Mycobacterium Tuberculosis Inhalation Acid Fast bacteria that also have Wax D (induce delayed hypersensitive rxn) and Cord Factor Causes Pulmonary TB + Miliary TB Triple therapy - LONG TERM - INH + rifampin Pyranzinamide |
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Term
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Definition
Mycobacterium leprae Leprosy. . . treat with Dapasone inhalation Likes to infect nerves |
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Term
White type of Leprosy can cause false + syphilis ? |
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Definition
Lepromatous
Tuberculoid does not , usually self limiting |
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Term
Most common cause of Human pneumonia |
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Definition
Streptococcus Pneumoniae polysaccharide capsule normal flora. . . inhalation classical lobar pneumonia Penicillin treatment vaccine - Conjugated Prevnar (kids 2 and younger) ; Multivalent Pneumovax (adults) |
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Term
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Definition
Bordetella Pertussis Virulent strains are encapsulated and toxin producing inhalation URT and LRT , paralysis of ciliated cells Vaccine - TDaP |
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Term
Secretes proteases which destroy cellular proteins spread through fine water mist |
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Definition
Legionella pneumophilia intracellular; motile; Legionnaires Disease URT illness Levofloxacin + Azithromycin |
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Term
Metachromatic granules and Pseudomembrane formation in URT |
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Definition
Corynebacterium Diptheriae Gram + ; "chinese characters" Diptheria Exotoxin (due to TOX gene bacteriophage transduction) inactivates EF2 rash indistinguishable from impetigo normal flora Vaccine - TDaP |
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Term
Catalase + with Polyribophosphate capsule, X factor, V-factor |
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Definition
Haemophelius (influenzae) requires blood components for growth X factor - hemin V-vactor - B complex vitamin Hib Vaccine |
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Term
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Definition
Klebsiella pneumoniae enteric organism ; large gelatinous capsule Intestinal and respiratory tract 2 species K.ozenae and K.rhinoscleromatis |
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Term
Neonatal Pneumonia and/or Meningitis |
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Definition
Listeria monocytogenes crosses placental and affects fetus Intracelular Psychrophilic Dairy product transmission (Brucellae, Coxiella brunii, Y.enterocolitica) Amoxicillin, Vancomycin, Ampicillin |
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Term
inhalation of dried bird feces |
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Definition
Chlamydia psitticosis atypical pneumonia resembling influenza*** No vaccine Antibiotics |
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Term
No cell wall ; requires cholesterol to grow ; Walking Pneumonia |
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Definition
Mycoplasma not effected by penicillin ; use tetracycline ; no vaccine
Obligate Intracellular |
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Term
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Definition
Sulfur granules "Lumpy Jaw" Normal Flora ; endogenous to the mouth Penicillin or Tetracycline Anaerobic |
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Term
2 acid fast (Zeil-Nelson stain) bacteria |
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Definition
Mycobacterium and Nocardia asterodies (pulmonary and CNS associated) |
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Term
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Definition
Actinomyces Bacillus Corenybacterium Clostridium Listeria Streptococcus Staphylococcus |
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Term
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Definition
Borrellia (spirocheate) also can cause Berreliosis and Lymes Disease Vector mediated |
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Term
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Definition
Borrelia Vencetti causes ANUG - acute necrotizing ulcerative gingivitis |
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Term
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Definition
Borrellia recurrentis - relapsing fever Ricketsiae Prowazakii - Epidemic typhus - obligate intracellular |
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Term
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Definition
Borrelia Burgdorferia - lymes disease Ricketsiae rickettseii - **Rocky Mountain Spotted Fever** - obligate intracellular |
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Term
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Definition
Borrelia duodenii soft-shelled tick borne warm weather multiple dose of tetracycline or erythromycin animal-human transmission via saliva of ticks |
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Term
Most common vector of tick (vector) borne disease in the USA |
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Definition
Borrelia burgdorferia Lyme's Disease Hard shelled Tick Erythma migrans - Bulls eye target rash CNS manifestations w/ AV block and subtle myocarditis and arthritis NO human to human Reservoirs : Rodents Deer, Domestic pets multiplel doses of oral Doxycycline |
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Term
Obligate intracellular organisms |
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Definition
Chlamydia Ricketsiae - ***except R.quintana = extracellular Mycoplasma |
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Term
Jaundice ; Weil's Disease ; Canicola fever |
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Definition
Leptospira interogans Leptospirosis - pathongenic Canicola - dog MOST COMMON in USA Contact with ANIMAL URINE. . . break in skin or inhalation Systemic disease involves. . . Brain, Lungs, Liver, Kidney (colonize) IV penicillin, YES vaccine |
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Term
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Definition
Undulating fever LPS endotoxin Intracellular B.melitenisis - goats&sheep , most pathogenic Localized to mammary glands & preg. uterus Skin abrasions, conjunctival exp, inhalation MILK UNPASTURIZED ! ( Y.enterolitica, Listeria, Coxiella bruneii) LONG LONG recovery weeks to months |
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Term
Coagulase produced at 28C, Rat flea vector |
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Definition
Yersina Pestis / Enterolitica Fraction I - antiphagocitic Black death, bubonic/pneumonic plegue LPS and Murine Exotoxin Optimum temp = 30C , envelope slime layer @37C Y.e. - milk - fever, bloody diarrhea - Resembles APPENDICITS Y.p - Rat flea - large painful buboes, vomit , diarrhea |
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Term
Typhoidal and Pneumotitis Tuleremia |
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Definition
Francicella TT - most serious - ingestion PT - most frequent - systemic JACK RABBITS ! Intracellular |
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Term
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Definition
*Pasturella multocida - most common organism from infected dog & cat bites *Actinomyces - sulfer granules *Streptococcus pneumoniae - most common pneumonia *Corenybacterium diptheriae - metachromatic g. pseudom. *Malisazia furfur (fungus - superficial mycoses) - UV green |
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Term
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Definition
Obligate intracellular *except for R.Quintana = extracellular |
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Term
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Definition
R.prowazekii human body louse vector - similar to B.recurrentis gangrene in severe froms highest fatality rate = 10-40% Yes vaccine |
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Term
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Definition
Rat flea - Y. pestis - black death, bubonic/pneumonic plague Rate Louse - R.typhi - Endemic typhus |
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Term
Rocky Mountain Spotted Fever |
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Definition
Ricketsiae Rickettsii Hard shelled tick - *similar to B.burgdorferia (lyme's dis) intravascular coagulation in severe cases |
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Term
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Definition
Coxiella brunii infected milk, inhalation (urine, feces, animal hides) Vector - arthropods , especially ticks possible GI symptoms and chest pain Doxycycline Vaccine- QVAX |
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Term
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Definition
HPV --> Oropharyngeal + cervical (16+18) Hepatitis B (HBV) --> (see below) Hepatitis C (HCV) --> hepatic cell carcinoma Epstein-Barr Virus (HHV4) --> Nasopharngeal + burkitts lym |
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Term
Lipid Envelope with E1 and E2 viral glycoproteins |
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Definition
Coronavirus +ssRNA, long helical structure Inhalation Respiratory Disease (URT) - NO FEVER Gastrointestinal disease growth cycle in cytoplasm |
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Term
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Definition
Polivirus - anterior horn cells of spinal cord*** & asp meng Coxsackie (A+B) virus - A - herpangina Echovirus - Rhinovirus - ONLY one that is inhalation , common cold Hepatitis A - jaudice |
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Term
General Picornavirus traits |
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Definition
+ssRNA No envelope Icosahedral Replicate in cytoplasm Stable at pH 3-5 |
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Term
anterior horn cells of spinal cord and possible Viral (aseptic) meningitis |
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Definition
Poliovirus ingestion - for all picornaviruses EXCEPT for rhinovirus +ssRNA No envelope , icosahedral Replicate in cytoplasm Progressive postpoliomyelitis muscle atrophy Vaccine: Salk (killed) , Sabin (live attenuated, BEST ONE) |
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Term
Lesions in CNS , heart muscle, other organs Neonatal disease, acute fatal encephalomyocarditis (infants) and acute myocardiopathy |
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Definition
Coxsackie B virus Coxsackie A virus --> herpangina BOTH grow in oropharnx and intestine Ingestion CNS and peripheral nerve involvement NEVER treat with Asprin --> Reyes syndrome |
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Term
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Definition
Coxsackie virus Influenza Virus Human Herpes Virus 3 - VZV
DO NOT TREAT WITH ASPRIN |
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Term
Only picornavirus that is transmitted via inhalation , Common cold |
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Definition
Rhinovirus Acid laible Heat stable (grow best at 33C) NO FEVER ***same as Coronavirus |
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Term
6 characteristics of a virus |
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Definition
Very small DNA or RNA (NOT BOTH) Obligate intracellular parasite No ribosomes Not susceptible to antibiotics specific tissue tropism |
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Term
4 ways of classification of viruses |
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Definition
Symmetry Nucleic Acid type Host cell type Serological relationships |
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Term
5 Enteroviruses of Picornaviruses |
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Definition
Poliovirus Coxsackie A virus Coxsackie B virus Echovirus Enterovirus |
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Term
True or False +ssRNA can create viral proteins immediately |
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Definition
True -ssRNA cannot, they need to make the template strand first. |
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Term
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Definition
HPV - circular DNA Hepatitis B - dsDNA Human Herpes Virus 1-8 - dsDNA |
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Term
Which of the following does not belong to the family Paramyxovirus? Parainfluenza, Respiratory Syncytial Virus, Measles, Mumps, Rubella |
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Definition
Rubella does NOT below to paramyxoviruses. it is a Togavirus +ssRNA ; Icosahedral Inhalation Fetus malformation + mild upper respiratory symptoms YES vaccine - MMR (live attenuated) |
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Term
which group of viruses has Hemagluttin-neuramidase and fusion glycoproteins ? |
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Definition
Paramyxoviruses
including (Measles, Mumps, RSV) |
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Term
What is the most important cause of lower respiratory tract illness in infants especially between 2-4months old ? |
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Definition
Respiratory Syncytial Virus (RSV) it is a paramyxovirus - linear RNA helical nucleoprotein capsid immediate hypersensitivity (type I - IgE) rxn Treat with Ribavirin |
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Term
Generalized exanthematous (skin eruption) disease with characteristic Koplik spots on buccal mucosa. |
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Definition
Measles inhalation Multinucleated giant cells - *similar to RSV syncitia reticuloendothelial system and Rash w/ possible CNS Prodromal fever Vaccine yes - MMR |
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Term
Killed vaccine which has no fusion proteins gives incomplete protection against ? |
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Definition
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Term
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Definition
1. Parotitis & salivary gland infection 2. Orchitis (testes/ovaries) 3. Aseptic meningitis (* similar to poliovirus) |
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Term
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Definition
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Term
HPV 16 and 18 are known causative agents of what type of cancer? |
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Definition
Cervical cancer
HPV 6 - Genital warts (condylomas) - most common STD HPV 1-4 - cutaneous warts |
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Term
Gardasil and Ceravix are used to treat what ? |
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Definition
Gardisil - HPV 6, 11, 16, 18 serotpyes - prevent warts and protect against cervical cancer.
Ceravix - HPV 16 and 18 serotypes protect ONLY against cervical cancer |
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Term
Condoms can reduce risk of what virus ? but not another ? |
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Definition
Condoms can reduce risk of HIV but NOT HPV |
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Term
What virus takes residence in the basal cell layer of squamous epithelial cells, but does not lyse them ? |
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Definition
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Term
Hemagglutinin (HA) and Neuraminidase (NA) are matrix proteins of what virus ? while hemagglutinin-neuraminidase (HN) is on the envelope of which virus ? |
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Definition
Q1: Influenza Virus - have HA and NA Q2: Paramyxoviruses (RSV, Measles, Mumps) - has HN
HA - helps with attachment to sialic from host cell for virus fusion NA - lowers the viscosity of the host cell membrane prior to vision release from cell. |
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Term
which two virus undergo massive amounts of genetic reassortment/change ? which of the two has a higher mutation rate ? |
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Definition
Influenza - changes yearly (genetic shift and/or drift) HIV - changes multiple times within an infected individual *HIV has a much higher mutation rate. |
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Term
Myxoviruses have an affinity for what type of environment ? |
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Definition
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Term
amantadine and rimantidine are used to treat what ? |
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Definition
Influenza A virus NOT effective against H5N1 or avian flu viruses.
Vaccines for influenza are typically Tri/tetravalent with several strains of A and B types |
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Term
Lipid enveloped virus is characteristic of what group ? are they DNA or RNA viruses ? |
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Definition
Orthomyxovirus (eg. Influenza virus) - -ssRNA Herpesvirus (eg. HSV1 , VZV,) - dsDNA HIV - 2 identical copies of linear ss RNA . . .needs Reverse Transcriptase |
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Term
Respiratory Papillomatosis is the result of ? |
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Definition
mother --> fetus viral transmission via aspiration of HPV during birth. |
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Term
what test detects for abnormalities of cells in the cervix of females ? |
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Definition
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Term
Which Hepatitis viruses are chronic ? which hepatitis viruses requires HBV infection prior ? Which hep. virus/es are sexual/blood transmitted ? What is the most important factor for measuring the infectivity potential of a hepatitis virus ? |
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Definition
Q1: Hep B, C, and D Q2: Hep D Q3: Hep B, C, and D Q4 : HBeAg |
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Term
what are 3 other viruses that can cause hepatitis ? |
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Definition
Epstein-Barr virus (human herpes virus 4) Cytomegalovirus (human herpes virus 5) Measles (rubeola) Mumps Rubella Coxsackievirus |
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Term
to be categorized as chronic hepatitis what is the criteria ?
Which is the most chronic hepatitis ? |
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Definition
HBsAg must be in circulation for 6months or LONGER.
Hepatitis C is most chronic |
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Term
in the early acute phase of Hepatitis A virus (HAV) what is present ? what about in the acute phase ? convalescent phase ? |
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Definition
anti-HAV IgM anti-HAV IgM and anti-HAV IgG anti- HAV IgG |
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Term
an individual is contagious with Hepatitis B as long as what 2 things are in circulation ? which of those would be absent during the convalescent phase "window phase" of an HBV infection? |
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Definition
HBsAg and HBeAg during the convalescent phase, only HBeAg would exist. HBsAg would be ABSENT ! |
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Term
which is more infective HIV or Hepatitis B ? |
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Definition
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Term
name a specific virus that is a Flavivirus ? Calicivirus ? |
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Definition
Hepatitis C = Flavivirus Hepatitis E = Calicivirus |
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Term
the most common human virus is ? |
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Definition
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Term
3 important life cycle growth traits of all herpes viruses are ? |
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Definition
1. "ballooning of cells" 2. intranucleuated inclusion bodies 3. multinucleate giant cells |
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Term
HSV1 commonly affects what area of the body ? where does it remain latent ? mode of transmission ? 2 characterisitc clinical findings include ? |
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Definition
Q1: oral cavity (lips) Q2: Trigeminal Ganglia Q3: inhalation via respiratory droplets OR direct contact Q4: Whitlow's infection (fingers) and Eczema herpeticum |
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Term
HSV2 primarily affects what part of the body ? mode of transmission ? site of latency ? what clinical manifestations ? |
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Definition
Q1 : Genitals Q2 : sexual OR mother--> fetus Q3 : Sacral ganglia Q4 : Genital herpes, neonatal herpes, and Whitlow's inf. + Eczema herpeticum |
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Term
What is the drug treatment for HSV1 and 2 ? what does it do ? |
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Definition
Acyclivor , nucleosides get phosphorylated by Thymidine kinase and DNA replication is blocked. |
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Term
What is Human Herpes Virus 3 ? |
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Definition
Varicella-Zoster Virus = chickenpox and shingles you cannot get shingles if you have not had chickenpox Varicella - mild, generalized rash, children usually Zoster - unilateral rash (follows nerve tracts), extremely painful, |
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Term
infectious Mononucleosis refers to what virus ? |
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Definition
Epstein-Barr virus (Human Herpes Virus 4) "Kissing Disease" - saliva immortalizes B cells, and remains latent in B cells Atypical lymphocytes and HETEROPHILE ANTIBODIES ! Nasopharyngeal carcinoma and Burkitt's Lymphoma |
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Term
what virus is called the salivary gland virus and exhibits cell gigantism, but has NO heterophile antibodies ? |
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Definition
Cytomegalovirus Latent in secretory glands and Kidneys |
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Term
Human Herpes Virus 6 and 7 have genomic similarity with ? but share ? |
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Definition
genomic similarity with Cytomegalovirus they share antigenic similarity
BOTH grow in T lymphocytes |
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Term
Kaposi's sarcoma is indicative of what 2 viruses ? |
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Definition
Human Herpes Virus 8 and HIV/AIDS |
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Term
what functions belong with head of the molecules. . . gp120 , gp41, CXCR4, CCR5 Where virus are these important for ? |
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Definition
gp120 - virus attachment to CD4 celles gp41 - fusion CXCR4 - T cell entry CCR5 - macrophage/monocyte entry HIV VIRUS ! |
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Term
What two viral infections can induce Fc receptors that help predispose an individual to contracting AIDS virus ? |
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Definition
HSV and CMV induce Fc receptors . . . these can be later used by the HIV virus-antibody complex to enter cells.
*NOTICE, both of these are Herpes Virus ! |
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Term
What is the hallmark for an AIDS virus infection ?
what is the major reservoir of the AIDS virus ? |
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Definition
T helper lymphocytes (CD4) get infected, easily killed, allow many progeny viruses, and form syncytia.
major reservoir is the Moncytes and macrophages |
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Term
What is the best predictor of AIDS virus outcome ? |
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Definition
Level of HIV1 RNA in the plasma ("viral load") |
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Term
What are 2 (3?)AIDS defining conditions ? What is the recommended treatment for HIV/AIDS ? |
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Definition
Q1 : Pneumocystis Carinii (Jirovecii) peumonia (PCP) Kaposi's Sarcoma
Histoplasma Capsulatum
Q2 : Highly Active Anti-Retroviaral Therapy (HAART) , it is a 3 drug combination (AZT, 3TC, and Indinavir). AZT targets Reverse transcriptase. Indinavir targets protease inhibitors. Prevention of envelop fusion with host cell membrane |
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Term
what is the screening test for HIV/AIDS ? what is the confirmatory test ?
if you are HIV positive during the screening test do you have HIV/AIDS ? |
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Definition
ELISA = screening test Western Blot = confirmatory test
Just because you are HIV+ in the ELISA screening test DOES NOT mean you have HIV/AIDS it is a possible false + |
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Term
What are the 3 dermatophytes ? which causes athletes foot ? which causes jock itch ? |
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Definition
Microsporium Trichophyton - athletes foot Epidermophyton floccosum - jock itch |
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Term
[image]is this macro or microconidia ? which family does it belong to ? |
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Definition
Macroconidia - large spindle shaped spines
Dermatophyte (sueprficial mycoses) - Microsporium
UV light fluorescence blue green
Treat with Allylamines (eg. Lamisil) and Azoles . . . BOTH target the sterols of the membrane |
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Term
[image]Micro or macroconidia ? which family do they belong to ? |
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Definition
Macroconidia - club shaped
Dermatophytes (superfical mycoses) - Epidermophyton f.
tinea cruris (groin) , pedis (foot), and unguium (nail) |
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Term
What is the causative agent of a superfical infection of the Stratum corneum ?
A sample taken from the infection fluoresces green.[image] |
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Definition
Malasazia furfur (lipophilic fungus)
"spaghetti and meatballs"
Normal flora . . .the ONLY other commensal along with Candida
causes Tinea Versicolor |
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Term
Not a dimorphic fungus
what is its tropism ?
[image] |
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Definition
Cryptococcus neoformans (systemic mycoses)
budding yeast organism
Polysaccharide capsule
Urease Positive
inhalation . . . high risk groups are immunocompromised
LUNG TISSUE infected
Tropism : Neurotropic for CNS --> Brain Abscess + Meningitis
Histological presentation - "fried egg" in brain tissue
best demonstrated with INDIA INK
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Term
has single buding yeast cells with Figure 8 nucleus. . .
treated with Oral Potassium Iodide (simple method)
[image]
slide 34 |
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Definition
Blastomyces dermatitidis
Inhalation . . . soil + birds
LUNG TISSUE
Most effective treatment is with Amphotericin B, Azoles, and antifungals |
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Term
What is this ? name of fungus ? Characteristic trait of yeast cells ?
[image]
slide 39 |
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Definition
Paracoccidiodes (blastomyces) brasilienis
multiple-buding yeast cells
has estrogen receptors preventing yeast formation
Associated with BATS and ARMADILLOS
Inhalation via Soil + plants
infects mucous membranes of nose, mouth, anus
IMPORTANT DIAGNOSTIC - development of multiple daughter cells + multiple budding yeast forms (see picture)
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Term
What is common to all the systemic mycoses ? |
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Definition
They all . . .
- are found environmentally related to soil
- are transmitted by Inhalation
- infect LUNG TISSUE
- can cause mucous-cutanous lesions under appropriate conditions , pulmonary lesions, dissemination
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Term
What is diagnostic characterisitic of Histoplasma Capsulatum?
[image]
slide 41 |
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Definition
DIAGNOSTIC = Tuberculated Chamydospores
Intracellular
spores are inhaled
LUNG TISSUE
in an HIV+ patient , considered an "AIDS defining illness"
"flu like" symptoms that can be confused with Miliary TB
can lead to Hepatosplenomegaly, leukopenia, and thrombocytopenia.
TREAT with Oral itraconazole
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Term
What is fungus is this ?
[image]
slide 43 |
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Definition
Histoplasma capsulatum
intracellular Tuberculated chlamydospores can be seen |
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Term
What is this fungi ?
[image] |
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Definition
Coccidiodies immitis . . . dimporphic
- arthrospores (arthroconidia) alteranating filled an unfilled
- endosporulating spherules in infected tissue
- valley fever
- Inhalation
- LUNG TISSUE
- Treat with Amphotericin B and/or Ketoconazole
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|
Term
What is this fungi ?
[image]
slide 47 |
|
Definition
Coccidiodies immitis
Endosporulating spherules |
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|
Term
Which of the systemic mycoses can be chronic ? |
|
Definition
Histoplasma capsulatum
and
Coccidiodies immitis |
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Term
which opportunistic fungi is NOT thermodimorphic ? |
|
Definition
Candida
- they can exist as yeast or mold regardless of temp.
- cause...oral thrush, cutaneous candidiasis, intestinal candidiasis, candida vaginitis , and systemic candidasis.
- Endogenous to mouth, surface of skin, intestine, vagina
- Broad-spec antibiotics, cortisone, anethesia, change in pH are all predisposing factors
- Topical Nystatin or amphotericin B - for treatment
- Ketoconazole for systemic infection
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Term
Penicillin producing ?
[image] |
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Definition
Aspergillus penicillium
exogenous species
opportunistic
lung tissue and invasion of blood vessel walls surrouunding tissue. |
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Term
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Definition
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|
Term
Once considered a protozoa , but now known as a fungus.
It is insensitive to Amphotericin B.
[image] |
|
Definition
Pneumocystis Carinii
- "deflated ball" shape
- lacks erosterol , so CANNOT use amphotericin or azole drug treatments
- almost EXCLUSIVELY seen in AIDS pts. (PCP)
- Trimethoprim-sulfamethoxazole (bactrium) - treat
- pentamindine (more toxic) - treatment
- SILVER STAIN of lung biopsy for yeat organisms (cysts)*
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