Term
| What is an alpha lipoprotein? |
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Definition
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Term
| What is a beta lipoprotein? |
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Definition
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Term
| What is a pre-beta lipoprotein? |
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Definition
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Term
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Definition
| IDL/remnants, typically indicative of disease |
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Term
| What is the relationship of HDL, LDL, and Coronary heart disease? |
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Definition
| Increasing LDL and Decreasing HDL in combination are significant predictors of Cardiovasular risk |
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Term
| What is type I Hyperlipoproteinemia? |
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Definition
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Term
| What is type IIa Hyperlipoproteinemia? |
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Definition
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Term
| What is type IIb Hyperlipoproteinemia? |
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Definition
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Term
| What is type III Hyperlipoproteinemia? |
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Definition
| Elevated Beta-VLDL (IDL/remnants) |
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Term
| What is type IV Hyperlipoproteinemia? |
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Definition
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Term
| What is type V Hyperlipoproteinemia? |
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Definition
| Elevated VLDL and Chylomicrons |
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Term
| Where do ingested triglycerides go? |
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Definition
| to adipose tissue and liver (then adipose again) |
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Term
| How are Fatty Acids transported? |
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Definition
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Term
| How are Triglycerides, phospholipids, and cholesterol transported? |
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Definition
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Term
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Definition
| proteins associated with plasma liposomes |
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Term
| What force keeps apoproteins attached to the lipoprotein membrane? |
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Definition
| Hydrophobic forces, apoproteins have hydrophillic/hydrophobic ends |
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Term
| What are the three major functions of Apoproteins? |
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Definition
1) Structural/exocytosis
2) Regulatory
3) Targeting |
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Term
| Which apoproteins are reversibly associated with the lipoprotein particles? |
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Definition
| Group 1 (A1, A2, A4, C1, C2, C3, and E) |
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Term
| What are the apoproteins that do not move from their respective lipoprotein? |
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Definition
Group 2:
B-100: VLDL/LDL
B-48: Chylomicrons |
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Term
| What is the function of LCAT/ACAT? |
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Definition
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Term
| What is the function of MTP? |
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Definition
| Resynthesis of lipolytic products into triglycerides in the intenstine. |
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Term
| What happens when MTP is malfunctioning? |
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Definition
| Disease state known as abetalipoproteinemia. Characterized by no LDL |
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Term
| When the chylomicron enters the lymph, which Apoproteins will be attached? |
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Definition
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Term
| What is the function of B48? |
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Definition
| allows secretion of chylomicron from intestine |
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
| Activate Lipoprotein Lipase |
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Term
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Definition
| prevents removal of triglyceride rich particles |
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Term
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Definition
| High affinity ligand for LDL receptor |
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Term
| What is the function of heparin sulfate? |
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Definition
Cell receptor that attracts LPL (lipoprotein lipase).
C2 will bind to LPL and allow for triglyceride degradation |
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