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Lipids
Graduate Biochem Lipids
53
Biochemistry
Graduate
09/27/2012

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Term
In liver: DHAP may, instead of going to glyceraldehyde 3-phostate, go to
Definition
Glycerol 3-phosphate
Term
Glycerol 3-phosphate + FACoA yields
Definition
Triglycerols which leads to production and release of VLDL
Term
Glucagon activates conversion of ATP to cAMP which in turn activates_________. Which activates ____________.
Definition
Protein kinase A. Hormone sensitive lipase.
Term
What does Hormone sensitive lipase do?
Definition
Breaks down triglycerols into 3 fatty acids + glycerol
Term
ACTH, TSH, and glucagon activate
Definition
Adenylyl cyclase
Term
Epinephrine, norepinephrine activate
Definition
Adenylyl cyclase
Term
B-Adrenergic blockers
Definition
inhibit epinephrine and norepinephrine
Term
Thyroid hormone activates
Definition
Adenylyl cyclase
Term
Insulin inhibits
Definition
Adenylyl cyclase, cAMP-independent pathway to activating hormone sensitive lipase
Term
Prostaglandin E1 inhibits
Definition
Adenylyl cyclase
Term
nicotinic acid inhibits
Definition
Adenylyl cyclase
Term
Adenylyl Cyclase
Definition
turns ATP into cAMP
Term
Growth hormone activates
Definition
Adenylyl cyclase
Term
Insulin activates
Definition
Lipase phosphatase and phosphodiesterase
Term
cAMP activates
Definition
cAMP dependent protein kinase
Term
cAMP dependent protein kinase + ATP
Definition
converts hormone sensitive lipase b(inactive) to hormone sensitive lipase a(active)
Term
Lipase phosphatase + MG2+
Definition
converts hormone sensitive lipase a(active) to hormone sensitive lipase
Term
Glucocorticoids via the cAMP-independent pathway
Definition
activate hormone sensitive lipase
Term
hormone sensitive lipase cleaves a triacylglycerol into
Definition
2 free fatty acids + 2-monoacylgylcerol
Term
2-monoacylglycerol is broken down into free fatty acid + glycerol by
Definition
2-monoacylglycerol lipase
Term
Phosphatidylethanolamine + Serine
Definition
ethanolamine and phosphatidylserine
Term
phosphatidylserine + decarboxylase + n-methyltransferase =
Definition
phosphatidylcholine
Term
dipalmitoylphosphatidylcholine is
Definition
major component of lung surfactant
Term
ratio of phosphatidyl choline to sphingomyelin in amniotic fluid is
Definition
>2:1
Term
Ceramide + UDP-glucose =
Definition
glucocerebroside which leads to globoside
Term
Ceramide + phosphatidylcholine =
Definition
sphingomyelin
Term
Ceramide + UDP-galactose =
Definition
galactocerebroside which leads to sulfatide
Term
glucosylceramide =
Definition
cer-Glu
Term
galactosylceramide =
Definition
cer-Gal
Term
lactosylceramide =
Definition
cer-Glu-Gal
Term
trihexosylceramide =
Definition
cer-Glu-Gal-Gal
Term
globoside =
Definition
cer-Glu-Gal-Gal_NAcGal
Term
Tay-Sach's Disease symptoms =
Definition
mental retardation, blindness, cherry red spot on macula, death between second and third year
Term
Tay-Sach's principal storage substance =
Definition
ganglioside GM2
Term
Tay-Sach's enzyme deficiency =
Definition
hexosaminidase A
Term
Gaucher's disease symptoms =
Definition
liver and spleen enlargement, erosion of long bones and pelvis, mental retardation in infantile form only
Term
Gaucher's disease principle storage substance =
Definition
glucocerebroside
Term
Gaucher's disease enzyme deficiency =
Definition
glucocerebrosidase
Term
Fabry's disease symptoms =
Definition
skin rash, kidney failure, pains in lower extremeties
Term
Fabry's disease principle storage substance =
Definition
ceramide trihexoside
Term
Fabry's disease enzyme deficiency =
Definition
a-Galactosidase A
Term
Niemann-Pick disease symptoms =
Definition
liver and spleen enlargement, mental retardation
Term
Niemann-Pick disease principle storage substance =
Definition
sphingomyelin
Term
Niemann-Pick disease enzyme deficiency =
Definition
sphingomyelinase
Term
phospholipase A2 acting on phosphotidylinositol releases
Definition
arachidonic acid (precursor of prostaglandins)
Term
phospholipase A2 is activated by
Definition
trypsin and requires bile salts
Term
phospholipase D is found in
Definition
plant tissue
Term
phospholipase C is found in
Definition
liver lysosomes and a-toxin of some bacteria, also in membranes as participant in producing second messengers
Term
phosphatidylcholine + phospholipase A2 =
Definition
lysophosphatidylcholine
Term
lysophosphatidylcholine + lysophospholipase =
Definition
glycerylphosphorylcholine
Term
triacylglycerol + lipases =
Definition
glycerol + fatty acids
Term
acyl CoA synthetase
Definition
makes fatty acyl CoA from fatty acid CoA and ATP
Term
Fatty acyl CoA + Carnitine:palmitoyltransferase 1(CPT 1) =
Definition
CoA + fatty acylcarnitine
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