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Lipids
Harpers 121-131
50
Other
Professional
08/22/2010

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Term
What are the properties of lipids?
Definition
  • Water insoluble, soluble in organic solvents like chloroform-methanol
  • exhibit structural heterogeneity
  • ionic or polar derivatives of hydrocarbons
  • amphipathic (having both polar and non polar ends)
Term
Saturated means...
Definition
no double bonds
Term
Unsaturated means...
Definition
Double bonds are present
Term
Saturated acids end in....
Definition
-anoic
Term
Unsaturated acids end in...
Definition
-enoic
Term
C16 Saturated
Definition
Palmitic
Term
C18 Saturated
Definition
Stearic
Term
C16:1;9
Definition
  • Palmitoleic
  • cis-9-hexadecenoic
Term
Where can you find the most occurences of palmitoleic acid?
Definition
In nearly all fats
Term
C18:1;9
Definition
  • Oleic
  • cis-9-octadecenoic
Term
Where can you find the most occurences of oleic acid?
Definition
most common in natural fats
Term
Where can you find the most occurences of Elaidic acid?
Definition
Hydrogenated and ruminant fats
Term
C18:1;9
Definition
  • Elaidic
  • trans-9-Octadecenoic
Term
C18:2;9,12
Definition
  • Linoleic
  • all-cis-9,12-Octadecadienoic
Term
Where can you find the most occurences of linoleic acid?
Definition
  • Corn, peanut, cottonseed, soybean, and many plant oils
Term
C18:3;6,9,12
Definition
  • Gamma-Linolenic
  • all-cis-6,9,12-Octadecatrienoic
Term
Where can you find the most occurences of gamma-linolenic acid?
Definition
  • Some plants
  • minor fatty acid in animals
Term
C18:3;9,12,15
Definition
  • Alpha-Linolenic
  • all-cis-9,12,15-Octadecatrienoic
Term
20:4;5,8,11,14
Definition
  • Arachidonic
  • all-cis-5,8,11,14-Eicosatertraenoic
Term
Where can you find the most occurences of arachidonic acid?
Definition
  • Animal fats
Term
Alcohol + Acid
Definition
Ester
Term
What is the main structural difference in PGE and PGF?
Definition
  • PGE has a keto (=O) group at position 9, while PGF has an alcohol (-OH) group at postion 9
Term
The notation of E1,E2,E on prostoglandins denotes
Definition
  • The number of double bonds on the prostoglandin side chain
Term
What is the most abundant natural fat?
Definition
Triacylglycerol
Term
Triacylglycerol after acid hydrolysis will yeild
Definition
Glycerol + 3F.A.
Term
Triacylglycerol after undergoing saponification will yeild.
Definition
Glycerol + 3MaFA
Term
What are the advantages of having lipids in the  -cis form vs. the -trans
Definition
  • Cis: Lowers the melting temp and increases membrane fluidity
  • Trans: Causes increased rigidity
Term
Cholesterol is the precursor for what?
Definition
Steroid hormones
Term
Where is cholesterol broken down and into what?
Definition
Liver, bile acid
Term
What are the fat-soluble vitamins?
Definition
A,D,E&K
Term
Glycerol-phosphate + 2F.A. =
Definition
Phosphatidic Acid
Term
Which alcohols are phosphoglycerides normally esterified with?
Definition
  • Choline
  • ethanolamine
  • serine
  • glycerol
  • inositol
Term
Another name for phosphatidyl choline
Definition
lecithin
Term
Another name for phosphatidyl ethanolamine
Definition
cephalin
Term
Another name for Diphosphatidylglycerol
Definition
Cardiolipin
Term
Another name for Dipalmitoyl lecithin
Definition
Surfactant
Term
Where are cardiolipins found?
Definition
Exclusively found in the inner membrane of mitochondria
Term
Another name for Dipalmitoyl lecitin
Definition
Surfactant
Term
Where are plasmologens abundant?
Definition
  • Nerve tissue
  • Heart tissue
  • Erythrocytes
Term
What happens when you hydrolyze the 2nd F.A. of a lecitin?
Definition
It becomes a lycolecitin
Term
Sphingosine + F.A. =
Definition
Ceramide
Term
Serine + Palmitoyl-CoA + Vit. B - CO2=
Definition
Sphingosine
Term
Sialic acid is composed of?
Definition
N-acetyl neuraminic acid
Term
  • What do gangliosides in cell membranes act as receptors for?
Definition
  • Viruses
  • Cholera toxin
  • Tetanus toxin
Term
Break down: GD1a,GM1b
Definition
  • G= globoside
  • D= disialic acid, M=monosialic acid
  • 1= 4 sugars (5-n)
  • a= different sugar, b= same sugar
Term
Sphingolipidosis
Definition
Accumulation of Sphingolipids
Term
Gaucher's disease
Definition
High Cerebrosides
Term
Tay Sachs
Definition
High gangliosides (GM2)
Term
Metachromatic Leukodystrophy (MLD)
Definition
high sulfatides
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