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Lipid transport and storage I
EXAM 2
39
Medical
Professional
09/01/2010

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Cards

Term
What is the function of chylomicrons?
Definition
they transport TAGs
Term
what is the function of LDL lipoprotein?
Definition
it delivers cholesterol from the liver to peripheral tissues
Term
VLDL function
Definition
transports TAG
Term
HDL function?
Definition
delivers cholesterol
Term
which lipoprotein has the highest comp of cholesterol? TAG
Definition
LDL. chylomicrons
Term
what is the structure of a lipoprotein?
Definition
nonpolar lipids associated w/proteins and amphipathic lipids
Term
the liver releases which lipoproteins?
Definition
VLDL, HDL
Term
which lipoproteins are released from the intestines?
Definition
chylomicrons
Term
what is in the core of plasma lipoprotein?
Definition
hydrophobic layer triacyl glycerol and cholesterol ester
Term
what is the outer component of lipoproteins?
Definition
hydrophillic layer of amphipathic apolipoproteins, phospholipid, and unesterified cholesterol
Term
what are lipoproteins characterized by
Definition
electrophoretic mobility
Term
which lipoprotein remains at cathode
Definition
chylomicron remnants
Term
where are apolipoproteins produced
Definition
in the liver and small intestines
Term
apolipoproteins help enzymes by
Definition
being a cofactor
Term
what is the major lipoprotein of HDL
Definition
apoA
Term
what is the major apolipoproteins of LDL
Definition
apoB
Term
major lipoprotein of VLDL
Definition
apoB
Term
chylomicrons' major apolipoprotein
Definition
truncated form of apoB
Term
what is the function of apoA
Definition
it activates cholesterol-lecithin transferase, which esterifies free cholesterol in HDL
Term
what is the function of apoB?
Definition
packaging and secretion
Term
function of Apo C
Definition
acts as enzyme activator and inhibitor
Term
where are chylomicrons assembled?
Definition
intestinal mucosal cells
Term
TG of circulating CM's are degraded by
Definition
lipoprotein lipase to form CM remnants
Term
when are CM remnants removed from circulation
Definition
when apoE binds to the lipoprotein receptor
Term
when spoproteins are degraded hydrolytically, what is released?
Definition
AA, FA
Term
where is LDL destroyed?>
Definition
liver
Term
what is hepatic lipase activity increased by and decreased by
Definition
androgens and estrogens
Term
this is an HDL receptor with a dual role in HDL metabolism.
Definition
class B scavenger
Term
what is the function of SR-B1?
Definition
mediates the acceptane of cholesterol efflux from the cells by HDL
Term
this receptor is involved in reverse cholesterol transport
Definition
class B scavenger receptor
Term
HDL exchanges apoproteins and cholesterol esters with other lipoproteins by what
Definition
CETP
Term
TGs and phospholipids are transferred from VLDL to HDL . where is CE going
Definition
from HDL to VLDL
Term
where are lipoprotein lipases found
Definition
attached to capillaries in muscle and adipose tissue
Term
what is the function of LPL
Definition
hydrolyzes TG in VLDL and chylomicrons to free FA's
Term
what is LCAT activated by
Definition
Apo A-1
Term
what is the function of LCAT?
Definition
catalyzes the transfer of FA from lecithin to free chlesterol in HDL
Term
what is the function of cholesterol ester transferase?
Definition
facilitates transfer of cholesterol from HDL
Term
what is the function of ACAT?
Definition
it catalyzes the conversion of free cholesterol to CE IN CELLS for storage.
Term
MTP does what
Definition
bind triglycerides to apoB
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