Term
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Definition
-Rhabdomyolysis
-Hepatotoxicity
-Neuropathy |
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Term
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Definition
-Pregnancy and Nursing mothers
-Drug interactions
- P450 3A4, increase warfarin levels
- OAT2 inhib (gemfibrozil)> ^ circ statin levels |
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Term
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Definition
Causes bile acid not to be reabsorbed, convert cholesterol to bile acids
-Useful when LDL ^
-May raise TG's
-decrease absorption of other drugs |
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
| -Blocks intestinal absorption of cholesterol (blocks N1C1L1) |
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Term
| Fibric Acids (Gemfibrozil and Fenofibrate) |
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Definition
-Decrease synth of VLDL
-Bind and activate PPARalpha
-Lowers TG and VLDL w/ ^HDL
-Increase FA oxidation in skeletal muscles
**Increase rhabdomyolysis with statins |
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Term
| Fibric Acid Contras and Drug intxn |
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Definition
-Sever renal or hepatic dx
-Displace warfarin, causing increase free warfarin (bleeding)
-Cyclosporine (increases of clearance, causing acute organ rejection) |
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Term
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Definition
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Term
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Definition
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Term
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Definition
-Makes more ApoA1 and reduces action of hormone sensitive lipase
-Reduces VLDL and LDL
-Most effective for raising HDL
Contra: Gout, liver dx, peptic ulcer |
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Term
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Definition
Antioxidant
-Inhibits cholesterol oxidation
Sfx: Increase QT interval (not use with people with long QT interval) |
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Term
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Definition
-Uptake by OATP2
-Peak plasma concentration 20 hours (lot longer than simvastatin and pravastatin) |
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Term
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Definition
| -Prodrug (simple diffusion) |
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Term
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Definition
-Uptake by OATP2 (active metabolites)
-Only one not metabolized at same Cytochrome P450 as the rest |
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