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LIPID-LOWERING AGENTS
LIPID-LOWERING AGENTS
12
Pharmacology
Professional
10/31/2011

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Cards

Term
Cholestyramine
Definition
Bile Acid Binding Resins
-take w/meal
-familial hypercholesterolemia
SE: GI disturbances common
-interferes with vitamins and drugs taken at same time
Term
Colestipol
Definition
Bile Acid Binding Resins
Term
Ezetimibe
Definition
Cholesterol Absorption Inhibitors
-at brush border but not used alone otherwise you get up reg of chol synth
-combine with HMG CoA reductase inhibitor
Term
Atorvastatin
Definition
HMG CoA Reductase Inhibitors
-most common drugs to correct hypercholesterolemia
SE:
-hepatotoxicity
-myopathy (muscle pain or weakness)
STATINS CONTRAINDICATED
*pregnancy
*liver disease
*major illness or trauma
Term
Lovastatin
Definition
HMG CoA Reductase Inhibitors
Term
Pravastatin
Definition
HMG CoA Reductase Inhibitors
Term
Simvastatin
Definition
HMG CoA Reductase Inhibitors
Term
Rosuvastatin
Definition
HMG CoA Reductase Inhibitors
Term
Niacin (Nicotinic Acid)
Definition
dec: TG, LDL
inr: HDL
-SE: cutaneous vasodilation
Contraindicated:
-history of peptic ulcer
-history of glucose intolerance
-gout
Term
Omega-3 fatty acid ethyl ester
Definition
DEC TG! and LDL
Contra: hypersensitivity, fish allergy!
Term
Fenofibrate
Definition
*Fibrate
PPARa--? dec apoB synthesis
dec: TG
inc:HDL
Use:
-dybetalipoproteinemia
-hyperTG
Term
Gemfibrozil
Definition
*Fibrate
PPARa--? dec apoB synthesis
dec: TG
inc:HDL
Use:
-dybetalipoproteinemia
-hyperTG
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