Term
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Definition
3% cancers adults
#1 cancer death children
.5 = acute (AML more common)
.5 = chronic (CLL more common)
increased risk trisomy 21
and fanconis chromosome instability |
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Term
| Aquired chromosomal abnormalities leukemia |
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Definition
9:22 - CML and some ALL
15:17 Acute ProMylo: retinoic acid receptor
8:21 - AML w/ maturation (favorable)
8:14 - Burkitts c-myc
12:21 - favorable ALL
11q23: poor prognosis
trisomy 8, monosome 5/7 - AML |
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Term
| Acute vs. chronic leukemia impt |
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Definition
1. acute = 20% blasts with sudden onset, constituitional sx and marked cytopenia (bone pain)
2. chronic = slow onset, slow sx, SPLENOMEGALY and mild cytopenias
both have neutropenia, thrombcytopenia, anemia
hepatomegaly,lymphadeno = CLL
splenomegally = cml
CNS = ALL
skin = aml |
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Term
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Definition
1. cytochemistry typical used CML
2. immunologic markers = ALL
CD34 = blast |
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Term
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Definition
Precursor B- 85% Markers CD19/10/34
Precursor T - 15% markers 2/5/6
number one cancer children, marked cns involvment, bone pain and may have low WBC counts |
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Term
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Definition
Number one leukemia adults can occur any age
GUM HYPERPLASIA
cytogenetics impt to classify
auer rods
CD 13/15/33 + 34,117
(8:21)(15:17)inv(16) - good
del5/7 - bad
APL - emergency ATRA for granule cyto
echymosis common |
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Term
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Definition
insufficient between M and L or
both B/T + M differentiation
poor prognosis
may be 9:22 or 11q23(MLL) |
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Term
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Definition
9:22 bcr-abl tk translocation releases weird mature cells from BM
age 26-60 + splenomegaly, basophilia, thrombocytosis
accelerated blast phase in 3 yrs |
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Term
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Definition
#1 leukemia western world
presents with increasing number infect.
B cell with CD 19/20/23 and 5
THINK 5/23
combs positive 15%, hypogamma 50%
lymphadenopathy + hepatospleno
Ricters transformation to prolymphocytic small cell = death 1 yr
del13q14 better, 17p worse |
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Term
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Definition
B cell 5:1 dry tap with fried egg appearance
Pancytopenia or monopenia with increasing bacterial/myco infections and splenomegaly
CD 19/20/22/11c/103/25
good prognosis with pentostatin |
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Term
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Definition
Mylodysplastic (5/7/8) syndrome with increased amn RBC +/- platelet/granulo
M>F, enlarged organs, increased visocity and tendency thrombosis
spent phase = myleofibrosis more common than CML
low erythorpoetin/increased uric acid/histamine --> differentiates from 2 or elevated volume |
|
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Term
| Chronic ideopathic myelofibrosis |
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Definition
Fibrosis BM related to EGFR and TGFb from abnormal megakaryocytes
extremedullary hematopoesis with tear drop cells
related to bm failure - death 3-5 yrs |
|
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Term
| Essential thrombocythemia |
|
Definition
| sustained elevated platelet count...indolent with thrombosis or hemoorage problems |
|
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Term
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Definition
overlaps with monocytosis (mylomonocytic)
less than 20% blast, no philadelphia chromo |
|
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Term
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Definition
tDT - ALL positive
CD 19 - pan B cell ag (good all)
CD 10 - CALLA antigen (all)
2/5/7 - T cell
14/15/33 - myeloid
34 - blast |
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