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Lens Pathology
Diseases of the Eye 1 - Optometry Waterloo
66
Pathology
Professional
11/13/2011

Additional Pathology Flashcards

 


 

Cards

Term
What are some anomalies of lens shape?
Definition

-lens coloboma (absence of zonules inferiorly)

-posterior lenticonus (conical bulge of posterior capsule)

-anterior lenticonus

-lentiglobus (hemispherical deformity)

-microphakia (small diameter)

-microspherophakia (small and round)

 

Term
What is ectopia lentis?
Definition

-displacement of lens from normal position

-luxated (complete displacement)

-subluxated (partial displacement)

-hereditary or acquiried

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Term
What type of lens defect might you suspect in a Px with Marfan syndrome?
Definition
-symmetrical bilateral subluxation (80%)
Term
What are some risk factors for developping Cataracts?
Definition

-trauma, radiation

-age, poor diet

-diabetes or hypothyroidism

-systemic and topical drugs

-high myopia or acute glaucoma

-congenital hereditary

Term
What do you call partial displacement of lens?
Definition
Sub-luxated
Term
Name a few ocular complications that may lead to Cataracts?
Definition

-chronic anterior uveitis

-acute glaucoma

-high myopia

-posterior segment disease

-dystrophia myotonica

Term
What type of cataract would you expect with a Px who comes in with diabetes and myotonic dystrophy? 
Definition
Bilateral
Term
What type of cataract would you expect for a person who has history of chronic uveitis?
Definition

Unilateral

 

Term
What are other causes of bilateral cataracts?
Definition

-retinitis pigmentosa

-atopic dermatitis

-myotonic dystrophy

-retinitis pigmentosa

Term

What the main causes of age related cataracts?

 

Definition

-aging changes in the lens are the result of accumuluation and compaction of lens fibers

-precipitation of lens proteins (alpha-crystallins)

Term
Which type of Cataract is granular with plaque like opacities?
Definition
posterior subcapsular
Term
Upon slit lamp examination you see opacities near nodal point of eye. Px reports severe difficulties in viewing and reading, which type of Cataract might you suspect?
Definition
Posterior subcapsular opacities
Term
You notice your patient has become more myopic since a recent last visit. His lens appears yellow-brown in appearance. What type of Cataract might you suspect?
Definition
Nuclear Sclerotic (exaggeration of natural aging changes)
Term
Upon slit lamp examination of lens you see spokes that  extend from outside to center of lens? What type of cataract might this be?
Definition
Cortical (can be anterior posterior or equatorial cortex)
Term
What type of cataract has characteristic needle-like deposits in the deep cortex and nucleus?
Definition

 

Christmas Tree Cataract (polychromatic)

Term
What classification is a cataract where anterior capsule is shrunken and wrinkled due to water loss?
Definition
Hypermature
Term
What is a morgagnian cataract?
Definition
-hypermature cataract with total liquefaction of the cortex, allowing nucleus to sink inferiorly
Term
A Px has cortical snowflake opacities, what other systemic disease might be present?
Definition
Diabetes Mellitus
Term
What are the classic types of presenile cataracts?
Definition

-diabetes mellitus

-myotonic dystrophy

-atopic dermatitis

-neurofibromatous

Term
What are common drugs related to cataracts?
Definition

-steroids

-chlorpromazine

-amiodarone

-allopurinol

Term
What is a secondary cataract?
Definition
Cataract that develops as a result of some other primary ocular disease
Term
What are hallmarks of cataracts due to chronic anterior uveitis?
Definition

-polychromatic lustre at posterior pole

-posterior and anterior opacities develop

-progress more rapid if posterior synechiae

Term
Which secondary cataract results in focal infarct of lens epithelium?
Definition
Acute angle closure cataract
Term
What type of lens manifestation do we see in pathologic myopia cataract?
Definition

-early onset nuclear sclerosis

-posterior subcapsular opacities

-not associated with simple myopia

Term
What are classic secondary cataract ocular diseases?
Definition

-chronic anterior uveitis

-acute congestive angle-closure

-high myopia

-hereditary fundus dystrophies

Term
What are some causes of congenital cataracts?
Definition

-genetic factors (most common)

-down sydrome

-galactosemia

-rubella

Term
What are ocular association of congenital posterior pole cataract?
Definition

-persistant hyaloid remnants

-posterior lenticonus

-persistant hyperplastic primary vitreous

Term
What are two key features you expect to see upon examination of a congential cataract?
Definition

-white reflex in pupil (leukocoria)

-usually unilateral (check for red reflex)

Term

What are some common causes of leukocoria?

 

Definition

-congenital cataract

-retinoblastoma

-persistant hyperplasia of primary vitreous

-retinal detachment

-toxocariasis

-posterior uveits

Term
What are some intrauterine causes of cataracts in unwell neonates?
Definition

-rubella

-toxoplasmosis

-cytomegalovirus

-varicella

Term
What are some metabolic disorders that cause cataracts in unwell neonates?
Definition

-galactosaemia

-hypoglycaemia

-hypocalcaemia

Term
Congenital Cataract is associated with a ________ cataract
Definition
lamellar
Term
What is the method of choice for cataract surgery today?
Definition
-phacoemulsification (uses ultrasound and leaves intact capsular bag)
Term
What are key parameters to obtain for Cataract surgery?
Definition

-axial biometry (A-scan) and corneal power (K's)

-final IOL position in eye

Term
What are the signs of mild endophthalmitis?
Definition

-mild pain

-mild visual loss

-anterior chamber cells

Term
When is the peak incidence of cystoid macular edema?
Definition
-6 weeks post-op
Term
What are some late post-operative complications?
Definition

-lens decentration

-corneal decomposition

-retinal detachment

Term
What are systemic diseases that present with ectopis lentis?
Definition

-marfan syndrome

-weill-marchesani syndrome

-homocystinuria

-hyperlysenemia

-sulphite oxidase deficiency

Term
What are some congenital/hereditary risk factors for cataracts?
Definition
-rubella, galactosemia, down syndrome,
Term
What are causes of developing unilateral cataracts?
Definition

-fuchs heterochromic uveitis

-chronic uveitis

-retinal detachment

-trauma

Term
What is the most popular type of cataract?
Definition
-posterior subcapsular
Term
What are the classifications of cataracts?
Definition
-capsular, subcapsular, cortical, nuclear, droplet
Term
Which illumination is best for looking at anterior and posterior subcapsular opacities?
Definition
-retroillumination
Term
Which cataract lies just in front of posterior capsule and is granular with plaque like opacities?
Definition
-posterior subcapsular
Term
Which common cataract starts as clefts or vacuoles between lens fibres?
Definition

-cortical

-then progresses to radial spokes

Term
What are the classifications of maturity of cataracts?
Definition

-immature (partially opaque)

-mature (fully opaque)

-hypermature (shrunken and wrinkled)

-morganian (liquefaction)

Term
What is the principal presenile cataract?
Definition
-DM
Term
What are the features of cataracts due to DM?
Definition

-age related occurs earlier and progresses faster

-can alter Rx and amplitude of accommodation

-snowflake may resolve or mature within a few days

Term
What is a glassblowers cataract?
Definition
-due to IR
Term
What are initial manifestations of cataracts due to steroids?
Definition

-initally is posterior subcapsular then anterior subcapsular is affected later

-may be genetically susceptible

Term
Which systermic drug may cause deposits fine granules on anterior lens capsule?
Definition

-chlorpromazine

-may also deposit on posterior cornea

Term
What effect does amiodarone have on cataract formation?
Definition
-50% of people on it show anterior subcapsular deposits
Term
What is the most common cause of a secondary cataract?
Definition
chronic anterior uveitis
Term
Which condition causes a secondary cataract that has a polychromatic lustre at posterior pole of lens, with both posterior and anterior opacities that develop?
Definition

-chronic anterior uveitis

-opacities progress more rapidly in presence of posterior synechiae

Term
Which condition causes glaucomflecken (small anterior subcap or capsular opacties)?
Definition
-acute angle closure glaucoma
Term
Which condtions causes posterior subcapsular opacities, and early nuclear sclerosis?
Definition

-pathologic myopia

-early nuclear sclerosis is factor increasing myopia

Term
Which hereditary fundus dystrophies are associated with posterior subcapsular opacities?
Definition

-retinitis pigmentosa

-leber congenital amaurosis

-gyrate atrophy

Term
Are congenital cataracts unilateral or bilateral
Definition
-2/3 are bilateral and common cause is genetic
Term
What type of cataract is capsular cataract?
Definition
-congenital
Term
What type of cataract is a posterior polar cataract and what are ocular associations?
Definition

-congenital

-persistant pupillary membrane, posterior lenticonus

Term
Where do we see focal dot opacities (blue dot cortical opacities)?
Definition
-congenital cataracts
Term
In severe congenital cataracts what is largely noticable?
Definition
-leukocoria (white reflex)
Term
What are possible reasons for congential cataracts?
Definition

-idiopathic

-inherited - usually bilateral

-associated with systemic disease

Term
What are the causes of cataracts in healthy neonate?
Definition

-hereditary (usually dominant)

-idiopathic

-with ocular anomalies (aniridia, coloboma, microphthalmos)

Term
What is needed for modern phaco surgery?
Definition

-prophylaxis (antibiotics and steroids)

-biometery (K's and A-scan)

Term
What are some early postoperative complications?
Definition

-CME (painless decrease in central VA, fluid filled cysts surrounding fovea)

-endopthalmitis

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