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Lecture #5 Hemoglobin Structure
Hematological/Immunological System
12
Medical
Professional
04/13/2011

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Term
HbA1C measurements are a good way to monitor:
Definition
Blood sugar levels over the past couple of months
Term
The heme binding site on Hb
Definition
Is surrounded by hydrophobic residues
Term
What is the total amount of hemoglobin in a normal adult?
Definition
About 750 grams
Term
If your patient has 9% HbA1c ( normal below 6% ) that suggests that the patient has
Definition
Diabetes
Term
Which of the following mutations is likely to stabilize met hemoglobin?
Definition
Substituting the distal His by a Glu in the E helical segment
Term
When compared to adult hemoglobin, fetal hemoglobin:
Definition
Is less sensitive to DPG
Term
Considering the role of the proximal and distal histidines:
Definition
The iron and the proximal histidine move on oxygen binding
Term
The oxygen binding form of the heme is the
Definition
Ferrous form
Term
The predominant hemoglobin in adults has the structure
Definition
Alpha2 Beta2
Term
A HbA1c level of 9% suggests that your patient
Definition
Has poorly controlled diabetes
Term
Bohr Effect refers to
Definition
Hb having lower affinity for Oxygen at low pH
Term
In HbS, a Glu is substituted by a Val in the beta chain. This means that the sickle cell beta chain
Definition
Will be more hydrophobic
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