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Lecture Outline 8
Overview of Immunology
40
Microbiology
Professional
02/20/2011

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Term
Immunology
Definition
the study of the immune system
Term
Self vs nonself surveillance
Definition
the ability to distinguish between self and nonself.
Term
Antigen
Definition
any substance capable of triggering an immune response
Term
Phagosytes
Definition
survey tissue compartments and discover microbes, particulate matter and dead or injured cells
Term
Disease
Definition
an alteration of a living body that impairs its functions
Term
Infectious Disease
Definition
Disease or disorder caused by a microorganism
Term
Resistance
Definition
the capacity of an organism, a tissue, or a cell to withstand the effects of a harmful physical or environmental agent. The capacity of an organism to defend itself against a disease.
Term
Susceptibility
Definition
Likely to be affected with a disease, infection, or condition
Term
Exogenous
Definition
an agent originating or produced outside of an organism, tissue, or cell that causes disease.
Term
Endogenous
Definition
an agent originating or produced within or caused by factors wwithin the organism that causes diseases
Term
Opportunistic
Definition
an infectious agent that can only cause disease when the host's resisance is low
Term
Extracellular/ Intracellular
Definition
located or occuring outside/inside the cell
Term
Adaptive Immunity
Definition
secondary form of immunity developed to meet specific needs
Term
Innate Immunity
Definition
genetically based and non-specific
Term
leukocytes
Definition

white bloodcells

found in the stem cells of bone marrow

Term
What is the first line of defense of innate immunity
Definition
skin
Term
Secondary defense in innate immunity
Definition
phagocytes
Term
J. Needham
Definition
emersed himself in the study of Chinese culture and science, primitive smallpox vaccination was used in China from the tenth century
Term
Mary Wortley Montagu
Definition
english writer who introduced smallpox inoculations to England
Term
Edward Jenner
Definition
developed a vaccination for smallpox
Term
Onesimus
Definition
was a slave who informed his master about the inoculation procedure in Africa when there was an outbreak in Boston
Term
Louis Pasteur
Definition
developed a vaccine against anthrax
Term
Elie Metchnikoff
Definition
Cellular Theory of Immunity: cells were responsible for the immune response ofan organism
Term
Behring and Kitasato
Definition
Humoral Theory of Immunity
Term
Lymph
Definition
means clear water. is the fluid and protein that has been squeezed out of the blood
Term
Lymphatic system
Definition
removes extracellular fluid that is left behind
Term
Primary lymohoid organs
Definition
Thymus and bone marrow
Term
Secondary lymphoid organs
Definition
Lymph nodes, spleen, tonsils, peyer's patches and appendix
Term
The three formed elements of the blood
Definition

leukocytes (white blood cells)

erythrocytes (red blood cells)

thrombcytes (platelets)

Term
Pluripotent stem cell
Definition
cells that are able to be any cell in the body
Term
Hematopoiesis
Definition
formation and development of the cells in the blood; myeloid and lymphoid
Term
myeloid lympohoid cells
Definition
thrombocytes, erythrocytes, ceutrophils, basophils, eosinophils, monocytes/macrophages, dendrictic cells
Term
Lymphoid stem cells
Definition
mature T & B cells , natural killer cells and dendritic cells
Term
Granulocyte
Definition
neutrophils, basophils, eosinophils
Term
Agranulocytes
Definition

Lyphocytes-T & B cells

Monocytes- macrophages

Term
Cytokine
Definition
a small protein released by cells that has a specific effect on the interactions between cells or on the behavior of the cells
Term
Chemokines
Definition
the cytokine that may activate or chemoattract leukocytes
Term
Interferon
Definition
an antiviral protein produced by cells that have been invaded by a virus
Term
Interleukinis
Definition
any of severy lymphokines that promote macrophages and killer T cells and B cells and other components of the immune system
Term
Tumor necrosis factors
Definition
refers to a group of cytokines family that can cause cell death
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