Term
How is the CNS activated? |
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Definition
pro-inflam cytokines bind to neurons of the SNS & PNS, diffuse into brain or are produced within the brain |
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Term
Activation of which part of the brain triggers the sickness response? |
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Definition
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Term
What triggers the fever response? |
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Definition
IL-1, IL-6 & TNF-alpha induce prostaglandin synthesis |
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Term
What effects does fever have on immune cells? (3) |
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Definition
-enhances DC maturation -increases number of circulating lymphocytes -inhibits T cell apoptosis |
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Term
How do poikilotherms generate a fever response? |
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Definition
swimming in warmer waters |
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Term
Which interleukin promotes the release of serotonin? |
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Definition
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Term
How does IL-1 lead to anorexia? |
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Definition
-suppresses neuropeptide-Y (a hunger signal) -induces production of HMGB1 (causes food aversion) |
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Term
Which 3 components of the immune system induce HMGB1 production? |
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Definition
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Term
How are bone marrow equivalent tissues activated? |
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Definition
G-CSF production is increased, which stimulates neutrophil differentiation |
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Term
Which interleukin is especially important in heptic synthesis of APP? |
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Definition
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Term
Which APPs are produced in the liver? |
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Definition
PRO CIBC Proteolytic enzyme neutralizers Radical scavengers Opsonins
Complement proteins Iron binding proteins Binding proteins Clotting factors |
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Term
Major APPs can increase in concentration by up to... |
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Definition
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Term
Moderate APPs can increase in concentration by up to... |
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Definition
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Term
Are major, moderate & minor APPs positive or negative? |
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Definition
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Term
Is C-reactive protein positive or negative? |
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Definition
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Term
Which receptors bind C-reactive protein? |
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Definition
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Term
Is C-reactive protein pro or anti inflammatory? |
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Definition
anti (inhibits neutrophil degranulation) |
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Term
Is Serum amyloid A positive or negative? |
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Definition
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Term
Serum amyloid A is an alarmin via ____ |
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Definition
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Term
Is Serum amyloid A pro or anti inflammatory? |
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Definition
pro (attracts neuts & mono) |
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Term
Transferrin is negative in _____ and positive in ____ |
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Definition
mammals chickens & zebrafish |
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Term
Haptoglobin is ______ in mammals and _____ in chickens |
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Definition
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Term
MAP protein is major in which species? |
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Definition
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Term
MAP protein is minor in which species? |
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Definition
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