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Lecture 5
The Endocrine System
47
Biology
Undergraduate 4
06/29/2011

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Term
hormones released by the endocrine system are called general hormones because
Definition
the affect many different tissue types
Term
what is the difference between exocrine and endocrine systems
Definition

exocrine systems release enzymes to the external environment through ducts like: sabacceous glands

 

endocrine system: release hormones directly into the blood stream

Term
why are the effects of the endocrine system slower
Definition
they are less direct because all endocrine hormones act by binding to receptors.  some organ tissue has many receptors while others have very few receptors
Term
what are the functions of the endocrine system
Definition
alter metabolic activities, regulate growth and development, and guide reproduction
Term
hormones exist in three basic chemistry types, what are they
Definition
peptide, steroid hormones, tyrosine derivatives
Term
discuss how peptides are manufactured from Rough ER to exocytosis
Definition
peptide hormones are essentially peptides.  They are manufactured in the rough ER as preprohormones.  these preprohormones are then cleaved into the ER lumen as prrhormones where they travel to the Golgi appartus to be packaged into vesicles and sent via exocytosis
Term
discuss how peptide hormones find a diffuse the effector cell (also called target cell)
Definition

peptide hormones are water soluble, thus are able to flow freely in the blood stream but have some difficulty diffusing through membranes

 

because of this, peptide hormones use receptor-bound membranes

Term
context: once the peptide hormone is bound to the receptor, what kinds of effects might happen to the membrane
Definition
the receptor may act as an ion channel and increase its permeablity to specific ions or it could lead to a second messenger such as cAMP, cGMP
Term
what do second messengers do
Definition
these activate or deactive enzymes and or ion channels which create a cascade effect of chemical reactions that amplify the hormone
Term
what are the anterior pituitary hormones
Definition
FSH, LH, ACTH, hGH, TSH and Prolactin
Term
what are the posterior pituitary hormones
Definition
ADH and oxytocin
Term
what is the parathyroid hormone
Definition
PTH
Term
what are the pancreatic hormones
Definition
glucagon and insulin
Term
what are the classifications of peptide hormones
Definition
anterior pituitary gland hormones, posterior pituitary gland hormones, parathyroid hormones and pancreatic hormones
Term
context: steroid hormones, where are these hormones formed, how do they travel through the blood stream and how do they work on transcriptional levels
Definition

steroid hormones are derived from and often chemically associated with cholesteral and formed in the smooth ER

 

since they are not water soluble, they use a protein transport molecule to help them travel through the blood stream

 

since steroids are lipid soluble they can travel across the membrane of cells and even diffuse through the cytosal and into the nucleus-this is why they act transcriptional levels

Term
what are the two groups of steroidal hormones
Definition
adrenal gland hormones and gonadal hormones
Term
what are the adrenal gland hormones
Definition
cortisol and aldosterone
Term
what are the gonadal hormones
Definition
estrogen, progesterone and testosterone
Term
what are the types of tyrosine hormones
Definition

thyroid hormones: T3, T4

 

catecholamines: norepinephrine and epinephrine

Term
where are all tyrosine hormones formed
Definition
they are formed by enzymes in the cytosal and rough ER
Term
what is the difference in solubility of thyroid hormones and catecholamines
Definition
catecholamines are water soluble (typically act through a second messenger mechanism), but thyroid hormones are not and need a plasma protein carrier to travel through the blood stream
Term
a secondary effect of aldosterone is to increase blood pressure.  would expected aldosterone levels be high or low in a person with low blood pressure
Definition
since aldosterone increases blood pressure, and the body tries to bring blood pressure back to normal, the adrenal cortex should release more aldosterone into the blood
Term
if ADH holds water in the body decreasing urine output and increasing blood pressure, does a person with high blood pressure have high or low ADH levels
Definition
low ADH levels because ADH output responded to the body- this is negative feedback
Term
the anterior pituitary gland secretes six major hormones, what are they
Definition

hGH-human growth hormone

ACTH-adrenocorticotrophin

TSH-thyroid-stimulating hormone

FSH-follicle-stimulating hormone

LH-leutinizing hormone

prolactin 

Term
what is the functions of hGH
Definition

stimulates growth in all cells by increasing the number of episode of mitosis 

 

it does this by increasing the amino acid transportation across the cell membrane

Term
what is the function of adrencorticotropic hormone
Definition

stimulate the adrenal cortex to release glucocorticoids

 

these are stress hormones using a second messenger of cAMP

 

Term
what is the function of thyroid stimulating hormone (TSH)
Definition

stimulate the release of T3 and T4 via second messenger system using cAMP

 

T3 and T4 have a negative feedback effect on TSH release

Term
what is the function of prolactin
Definition
promotes lactation by the mammary glands (breats) of women
Term
what are the hormones of the posterior pituitary gland
Definition
adh and oxytocin
Term
what is the function of oxytocin
Definition
oxytocin increase the uterine contractions during pregnancy
Term
what is the function of ADH
Definition
this is an antidiuretic hormone also called vasopressin which causes collecting ducts in the kidneys to become permeable to water thus decreasing the amount of urine excreted
Term
what are the only types of hormones that the adrenal cortex secretes
Definition
steroid hormones
Term
what is the function of aldosterone
Definition

increases the sodium and potassium activity

 

*(sodium reabsorption and potassium secretion)*

Term
what is the function cortisol
Definition

increases blood glucose levels by stimulating gluconeogenesis in the liver

 

recall that this is a stress hormone

 

degrades adipose tissue to fatty acids to be used in cellular energy

Term
where are catecholamines formed
Definition
in the adrenal medulla
Term
what are the functions of catecholamines
Definition
they are vasoconstrictors of the skin and internal organs but are vasodilators of skeletal muscles
Term
what are the functions of T3 and T4
Definition

increase the basal metabolic rate

 

and are affected by TSH

Term
what is the function of calcitonin
Definition
decrease the blood calcium by decreasing osteoclasts
Term
what is the function of the peptide hormone insulin
Definition

secreted by the pancreas, its job is to lower blood glucose levels

 

storing fat in adipose, glycogen in the liver and muscles

Term
what is the function of the peptide hormone glucagon
Definition
stimulates the breakdown of glycogen, increasing blood glucose levels
Term
what is the function of the peptide hormone parathyroid hormone
Definition
increase blood calcium, increase osteocyte absorption of calcium and phosphate form the bone and stimulates proliferation of osteoclasts
Term
what is the function FSH
Definition
surround and nurture the spermatocytes
Term
what is zona pellucida
Definition
this is a viscous substance around the egg 
Term
when a zygote is comprised of eight or more cells its called a
Definition
morula
Term
what is the first outward sign of pregnancy
Definition
human chorionic gonadotropin in the blood and urine of the mother
Term
during gastrulation what are the three primary germ layers
Definition
ectoderm, mesoderm, and endoderm
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