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form direct cytoplasmic connections b/w adjacent cells |
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contact dependent signals |
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require interaction between membrane molecules |
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not enough receptors-treat by inhibiting enzyme that breaks down Ach |
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-indirectly linked with ion channels on plasma membrane -g protein coupled receptor -amplification |
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-olfactory -activates protein kinases (A) -binds to ion channels -phosphorylates proteins -alters channel opening |
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-vision -activates protein kinases (G) -binds to ion channels -phosphorylates proteins -alters channel opening |
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metabotropic receptors cAMP pathway |
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-adenylyl cyclase (amplifier enzyme) turned on by G protein -converts ATP to cAMP -kinase A phosphorylates other proteins leading to a response |
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cause Ca release in muscle |
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postsynaptic membrane and receptors |
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receptor numbers permeability degradation rates |
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-nicotinic-ICR -muscarinic-GPCR |
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norepinephrine dopamine serotonin |
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inhibitory (open CL channels) make GABA receptors work better for anxiety problems |
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