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LECTURE 3
GI/HEPATIC
133
Medical
Professional
08/16/2013

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Term
RISK FACTORS FOR PRIMARY LIVER CANCER
Definition
HEP B, C
AFLATOXIN
VINYL CHLORIDE
ALCOHOL
CARBONIC TETRACHLORIDE
ANYLINE DYES
SMOKING
HEMOCHROMATOSIS
BENZENES
SCHISTOSOMIASIS
Term
CARCINOID TRIAD
Definition
FLUSHING
WHEEZING
DIARRHOEA
Term
HOW TO DIAGNOSE CARCINOID
Definition
BY MEASURING 5-HIAA IN THE URINE
Term
MOST COMMON PRIMARY LOCATION FOR CARCINOID
Definition
APPENDIX
Term
MOST COMMON METASTATIC ORIGIN FOR CARCINOID
Definition
SMALL BOWEL
Term
MOST COMMON METASTATIC SITE FOR CARCINOID
Definition
LUNG/HEART
Term
MOST COMMON BENIGN LOCATION FOR CARCINOID
Definition
APPENDIX
Term
WHAT IS A XANTHOMA?
Definition
SIGN OF ELEVATED CHOLESTEROL FOUND ON EXTENSOR SURFACES
Term
XANTHOMAS INCREASE THE RISK OF WHAT?
Definition
CORONARY ARTERY DISEASE
(CAD)
Term
WHAT IS A XANTHELASMA?
Definition
SIGN OF ELEVATED TRIGLYCERIDES
FOUND ON EYELIDS AND FACE
Term
XANTHELASMA INCREASES THE RISK OF WHAT?
Definition
PANCREATITIS
Term
RISK FACTORS FOR ESOPHAGEAL/GASTRIC CANCER
Definition
SMOKING
ALCOHOL
NITRATES
JAPANESE/SAKI
Term
GASTROENTERITIS WITHIN 8 HOURS OF EATING
(PRE-FORMED TOXIN)
Definition
S.AUREUS(POTATO SALAD)
C.PERFRINGES (HOLIDAY TURKEY/HAM)
B.CEREUS (FRIED RICE)
Term
BACTERIA ASSOCIATED WITH COLON CANCER
Definition
C.MELANOGOSEPTICUS
S.BOVIS
Term
CHYLOMICRONS
Definition
TAKES TRIGLYCERIDES FROM GI TO LIVER AND ENDOTHELIUM
Term
VLDL
Definition
TAKES TG FROM LIVER TO ADIPOSE
ONLY MADE IN LIVER
Term
IDL
Definition
TAKES ADIPOSE FROM ADIPOSE TO TISSUE
Term
LDL
Definition
ONLY ONE TO CARRY CHOLETEROL
Term
IDL+LDL
Definition
BREAK DOWN PRODUCTS OF VLDL
Term
TX FOR HYPERCHOLESTEROLEMIA
Definition
STATINS
PRAVASTATIN (ONLY ONE RENALLY EXCRETED)
ATORVASTATIN- LIVER ENZYMES EVERY 3/12
LOVASTATIN - "
SIMVASTATIN - "
Term
MOA
Definition
INHIBIT HMG COA REDUCTASE
MOST ACTIVE AROUND 8PM
MUST TAKE AT NIGHT FOR MAX EFFICACY
Term
ACUTE RECENT HEP B INFECTION
Definition
HBcAg+, HBsAg+ (HBcAb +/-)
Term
RECENT IMMUNIZATION WITHIN 2/52
Definition
HBsAg+ ONLY
Term
IMMUNISATION >2/52
Definition
HBsAb+ ONLY
Term
PREVIOUS INFECTION , NOW IMMUNE
Definition
HBcAb+, HBAb-, HBsAg-
Term
INFECTIOUS
Definition
HBeAg+
Term
NON-INFECTIOUS
Definition
HBeAg-
Term
CHRONIC CARRIER
Definition
HBsAg+ FOR MORE THAN 6/12 (HBsAb +/-)
Term
WINDOW PERIOD
Definition
HBeAb+, HBcAb+,
Term
DEFICIECY TYPE I HYPERLIPIDEMIA
Definition
LPL DEFECT OF THE LIVER TYPE ONLY
Term
INCREASED COMPONENT IN TYPE I HYPERLIPIDEMIA
Definition
CHYLOMICRONS
Term
DEFICIENCY IN TYPE IIa HYPERLIPIDEMIA
Definition
CLARITHIRIN PIT OR B100
Term
INCREASED COMPONENT IN TYPE IIa HYPERLIPIDEMIA
Definition
LDL
Term
DEFICIENCY IN TYPE IIb HYPERLIPIDEMIA
Definition
LDL/VLDL RECEPTORS
Term
INCREASED IN TYPE IIb HYPERLIPIDEMIA
Definition
LDL & VLDL
Term
TYPE IIb HYPERLIPIDEMIA
Definition
MOST COMMON IN GENERAL POPULATION
Term
DEFICIENCY IN TYPE III HYPERLIPIDEMIA
Definition
APOE
Term
INCREASED IN TYPE III HYPERLIPIDEMIA
Definition
IDL
Term
DEFICIENT IN TYPE IV HYPERLIPIDEMIA
Definition
LIPOPROTEIN LIPASE OF ADIPOSE TISSUE
Term
WHAT IS INCREASED IN TYPE IV HYPERLIPIDEMIA?
Definition
VLDL
Term
DEFICINCY IN TYPE V HYPERLIPIDEMIA?
Definition
CHYLOMICRONS AND VLDL
ASSOCIATED WITH DIABETES MELLITUS
Term
CORKSCREW ON XRAY
Definition
ESOPHAGEAL SPASM
Term
APPLE CORE ON XRAY
Definition
CANCER
Term
STACKED COIN ON XRAY
Definition
INTUSSUSCEPTION
Term
ABRUPT CUT OFF ON XRAY
Definition
VOLVULOUS
Term
BIRD'S BEAK ON XRAY
Definition
ACHALASIA
Term
STRING SIGN ON XRAY
Definition
PYLORIC STENOSIS
Term
CAUSES OF SOLID DYSPHAGIA
Definition
SCHATZKI'S RINGS
STRICTURES
CANCER
Term
SCHATZKI'S RINGS
Definition
LOWER ESOPHAGEAL WEBS
Term
CAUSES OF LIQUID DYSPHAGIA
Definition
SCLERODERMA
ACHALASIA
Term
BARRETT'S ESOPHAGUS
Definition
METAPLASIA
INCREASED ADENOCARCINOMA RISK
Term
ESOPHAGEAL VARICES
Definition
DUE TO PORTAL HYPERTENSION
VOMIT BLOOD WHEN THEY RUPTURE
Term
MALLORY-WEISS
Definition
CHRONIC VOMITTERS
TEAR AT THE LES MUCOSA
Term
BOERHAAVE'S ESOPHAGUS:
Definition
"TRANSMURAL" ALL LAYERS OF ESOPHAGUS
Term
ACHALASIA: (ALSO CHAGAS)
Definition
HIGH LES PRESSURE
DECREASED PERISTALSIS
LOST LES AUERBACH'S
BIRD'S BEAK XRAY
Term
HIRSCHSPRUNG'S
Definition
CONGENITAL LACK OF AUERBCH'S IN THE RECTUM
NEWBORN WON'T PASS MECONIUM
Term
ZENCKER'S DIVERTICULUM
Definition
ABOVE UES
COUGH UNDIGESTED FOOD
HALITOSIS
Term
TRACTION DIVERTICULUM
Definition
BELOW THE UES
Term
PLUMMER VINSON SYNDROME
Definition
ESOPHAGEAL WEBS (UES)
SPOON NAILS
IRON DEFICIENCY ANEMIA
Term
BARRETT'S ESOPHAGUS:
Definition
METAPLASIA
INCREASED ADENOCARCINOMA RISK
Term
ESOPHAGEAL VARICES:
Definition
DUE TO PORTAL HYPERTENSION
VOMIT BLOOD WHEN THEY RUPTURE
Term
MALLORY-WEISS:
Definition
CHRONIC VOMITERS
TEAR AT THE LES MUCOSA
Term
BOERHAAVE'S ESOPHAGUS:
Definition
"TRANSMURAL" ALL LAYERS OF ESOPHAGUS
Term
ACHALASIA: (ALSO CHAGAS)
Definition
HIGH LES PRESSURE
DECREASED PERISTALSIS
LOST LES AUERBACH'S
BIRD'S BEAK X-RAY
Term
HIRSCHSPRUNG'S:
Definition
CONGENITAL LACK OF AUERBACH'S IN THE RECTUM
NEWBORN WONT PASS MECONIUM
Term
ZENCKER'S DIVERTICULUM:
Definition
ABOVE UES
COUGH UNDIGESTED FOOD
HALITOSIS
Term
TRACTION DIVERTICULUM
Definition
BELOW UES
Term
PUMMER-VINSON SYNDROME:
Definition
ESOPHAGEAL WEBS (UES)
SPOON NAILS
IRON DEFICIENCY ANEMIA
Term
TE FISTULA (H-TYPE)
Definition
CHOKE WITH EACH FEEDING
Term
ESOPHAGEAL ATRESIA W/TE FISTULA :(C-TYPE)
Definition
VOMIT WITH 1ST FEEDING
HUGE GASTRIC BUBBLE
Term
DUODENAL ATRESIA:
Definition
BILIOUS VOMITING WITH 1ST FEEDING
DOUBLE BUBBLE
DOWN'S SYNDROME
Term
PYLORIC STENOSIS:
Definition
NON-BILIOUS PROJECTILE VOMITING (3-4 WK LD)
RUQ OLIVE SIGN
Term
CHOANAL ATRESIA:
Definition
TURNS BLUE W/FEEDING "SMURF ON A NIPPLE"
(V/S TOF WHICH TURNS BLUE WHEN CRYING)
Term
BEZOAR:
Definition
ANTRUM OBSTRUCTION DUE TO MASS OF UNDIGESTIBLE MATERIAL
Term
TYPE A GASTRITIS:
Definition
AUTOIMMUNE
ANTI-PARIETAL CELL ANTIBODIES
ATROPHIC/ACHLORHYDRIA
ADENOCARCINOMA INCREASED RISK
Term
TYPE B GASTRITIS:
Definition
H.PYLORI
SPICY FOODS
Term
DUODENAL ULCER:
Definition
LOSS OF BARRIER
PAIN AFTER MEAL & DURING THE NIGHT
RELIEVED BY EATING (WT GAIN)
ASSOC W/ H.PYLORI
TYPE O BLOOD
Term
GASTRIC ULCER:
Definition
LOSS OF BARRIER
PAIN DURING MEALS
ASSOCIATED W/ NSAIDS, TYPE A BLOOD
Term
SLIDING HIATAL HERNIA:
Definition
FUNDUS SLIDES THROUGH ESOPHAGEAL HIATUS INTO THORAX
Term
ROLLING HIATAL HERNIA
Definition
BOWEL PROTRUDES THROUGH A DEFECT IN THE DIAPHRAGM
STRANGULATES BOWEL
Term
MENETRIER'S DISEASE:
Definition
LOOSE PROTEIN THROUGH THE RUGAL FOLDS (GENERALISED EDEMA)
THICK RUGAL FOLDS
Term
DIARRHOEA:
Definition
>200G/DAY
OSMOTIC: WATERY
SECRETORY:LAXATIVE USE
INFLAMMATORY: BLOOD/PUSS
Term
CELIAC SPRUE:
Definition
DISTAL ILEUM
Term
MSENTERIC ISCHEMIA:
Definition
PAIN OUT OF PROPORTION TO EXAM
Term
BUGS THAT CAUSE BLOODY DIARRHEA:CASES
Definition
CAMPYLOBACTER
AMOEBA (E.HISTOLYTICA)
SHIGELLA
E.COLI
SALMONELLA
Term
CHOLANGITIS:
Definition
INFLAMMATION OF THE BILE DUCT
CHARCOT'S TRIAD:
-JAUNDICE
-FEVER (USUALLY W/ RIGORS)
RUQ PAIN
REYNOLD'S PENTAD:
TRIAD AS ABOVE +..
HYPOTENSION
CHANGE IN MENTAL STATUS
Term
ASCENDING CHOLANGITIS:
Definition
COMMON BILE DUCT INFECTION DUE TO STONE
Term
PRIMARY SCLEROSING CHOLANGITIS :
Definition
P-ANCA
BILE DUCT INFLAMMATION
BEADING
ASSOC W/UC
Term
PRIMARY BILIARY CIRRHOSIS:
Definition
ANTI-MITOCHONDRIAL Ab
BILE DUCT DESTROYED
XANTHELASMA
Term
CHOLESTASIS:
Definition
OBSTRUCTION OF BILE DUCT
PRURITIS
INCREASED ALK PHOS
JAUNDICE
Term
CHOLELITHIASIS:
Definition
FORMATION OF GALLSTONES
RUQ COLIC
Term
CHOLEDOCHOLITHIASIS:
Definition
GALLSTONE OBSTRUCTS BILE DUCT
Term
MC GALLSTONE:
Definition
CHOLESTEROL (INVISIBLE ON X-RAY)
Term
GALLSTONE SEEN ON X-RAY:
Definition
CA-BILIRUBINATE
Term
CONJUGATED BILIRUBIN:
Definition
WATER SOLUBLE
"DIRECT"
Term
UN-CONJUGATED BILIRUBIN:
Definition
FAT SOLUBLE
"INDIRECT"
Term
SIGN OF ALCOHOLIC CIRRHOSIS:
Definition
SPIDER ANGIOMA
PALMAR ERYTHEMA
GYNECOMASTIA
Term
HEPATORENAL SYNDROME:
Definition
BUILD UP OF LIVER TOXINS CAUSES RENAL FAILURE
Term
XANTHOMA:
Definition
CHOLESTEROL BUILD UP (ELBOW, ACHILLES)
Term
HIGH CHOLESTEROL:
Definition
ATHEROSCLEROSIS
Term
XANTHELASMA:
Definition
TG BUILD UP UNDER THE EYE
Term
HIGH TRIGLYCERIDES:
Definition
PANCREATITIS
Term
CRIGLER-NAJJAR TYPE I:
Definition
UNCONJUGATED BILIRUBIN BUILD UP IN INFANTS
Term
GILBERT SYNDROME:
Definition
STRESS=> INCREASED UNCONJUGATED BILIRUBIN
INCREASED LOAD SATURATES GLUCURONYL TRANSFERASE
Term
ROTOR'S:
Definition
BAD BILIRUBIN STORAGE=>INCREASED CONJUGATED BILIRUBIN
Term
DUBIN-JOHNSON:
Definition
BAD BILIRUBIN EXCRETION=> BLACK LIVER (INCREASED CONJUGATION BILIRUBIN)
Term
HEMORRHAGIC PANCREATITIS:
Definition
CULLEN SIGN: BLEEDING AROUND UMBILICUS
TURNER'S SIGN: BLEEDING INTO FLANK
Term
TEST FOR FOLLOWING PANCREATITIS:
Definition
AMYLASE (SENSITIVE)BREAKS DOWN CARBOHYDRATE
LIPASE (SPECIFIC) BREAKS DOWN TGs
Term
RANSON'S CRITERIA:
Definition
PROGNOSIS FOR PANCREATITIS
Term
RANSON'S CRITERIA AT PRESENTATION:
Definition
WBC>16K/uL
AGE>55 (USUALLY MULTIPLE ILLNESSES)
GLUCOSE>200(ISLET CELLS AFFECTED)
LDH>350IU/L (CELL DEATH)
AST>250IU/L (CELL DEATH)
Term
RANSON'S CRITERIA AT 48HRS:
Definition
BUN HIGH >5MG/dL (DECREASED RENAL BLOOD FLOW)
Ca<8Mg/dL (SAPONIFICATION)
HCT DROPS >10% (BLEEDS INTO PANCREAS
SEQUESTER >6L FLUID (3RD SPACING)
pO2<60mmHg (FUILD/PROTEIN LEAK, ARDS)
Term
CARCINOID SYNDROME:
Definition
FLUSHING, WHEEZING, DIARRHEA
Term
CURRANT JELLY SPUTUM:
Definition
KLEBSIELLA
Term
CURRANT JELLY STOOL:
Definition
INTUSSUSCEPTION
Term
FAMILIAL POLYPOSIS:
Definition
100% RISK OF COLON CANCER
APC DEFECT
BEGIN ANNUAL COLONOSCOPY AT 5 YRO
Term
GARDENER'S SYNDROME:
Definition
FAMILIAL POLYPOSIS W/BONE TUMOURS
Term
TURBOT'S SYNDROME:
Definition
FAMILIAL POLYPOSIS W/BRAIN TUMOURS
Term
PUETZ-JEGHER SYNDROME:
Definition
HYPERPIGMENTED MUCOSA
Term
CROHN'S DISEASE:
Definition
IBD W/COBBLESTONES, MELENA, CREEPING FAT, FISTULA
Term
ULCERATIVE COLITIS
Definition
IBD W/PSEUDOPOLYPS,HEMATOCHEZIA, LEAD PIPE COLON, TOXIC MEGACOLON
Term
INTUSSUSCEPTION
Definition
CURRENT JELLY STOOL, STACKED COIN ENEMA
Term
HOW DOES DIVERTICULOSIS PRESENT?
Definition
BLEEDS
Term
HOW DOES DIVERTICULITIS PRESENT?
Definition
PAIN IN LLQ
Term
HOW DOES SPASTIC COLON PRESENT?
Definition
INTERMITTENT SEVERE CRAMPS
Term
HOW DOES IBS PRESENT?
Definition
ALTERNATING DIARRHEA/CONSTIPATION WITH A HISTORY OF STRESS
Term
HOW DO EXTERNAL HEMORRHOIDS PRESENT?
Definition
PAIN ON DEFECATION
Term
HOW DO INTERNAL HEMORRHOIDS PRESENT?
Definition
NO PAIN
Term
WHAT IS PSEUDOMEMBRANOUS COLITIS?
Definition
OVERGROWTH OF C.DIFFICILE DUE TO NORMAL FLORA BEING KILLED OFF (USUALLY BY CLINDAMYCIN USE)
Term
WHAT IS WHIPPLE'S DISEASE?
Definition
T.WHIPPLEII DESTROY GI TRACT, THEN SPREAD CAUSING MALABSORPTION, ARTHRALGIA
Term
WHAT COLOUR IS AN UPPER GI BLEED?
Definition
BLACK
Term
WHAT COLOUR IS A LOWER GI BLEED?
Definition
RED
Term
WHAT ADDS COLOUR TO THE STOOL?
WHAT GIVES URINE ITS YELLOW COLOUR?
Definition
STERCOBILINOGEN BEING OXIDISED TO STERCOBILINOGEN BEING OXIDISED TO STERCOBILIN
UROBILINOGEN BEING OXIDISED TO UROBILIN
Term
WHAT IS THE DEFAULT COLOUR OF STOOL?
Definition
CLAY COLOURED
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