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Lecture 23: Drugs re: Prostaglandins
N/A
16
Medical
Professional
08/31/2013

Additional Medical Flashcards

 


 

Cards

Term
alprostadil
Definition

PGE

 

-tx of peripheral vascular disease

 

-maintains patent ductus arteriosus

 

Mnemonic: Baby "Al" needs to keep his "p"atent ductus arteriosus open so he can stay alive and eat "dil"l.

Term
Misoprostil
Definition

PGE analog

 

-tx of gastric ulcers

 

Mnemonic: Miso soup hits the stomach.

Term
Dinoprostone
Definition

PGE2

 

induce labor + abortions

 

Mnemonic: Carbon (other drug) dating puts dinosaur in the uterus.

Term
Carboprost
Definition

15 methyl-PGF-2alpha

 

-induce labor and abortions

 

-tx for post partum hemorrhage due to uterine anatomy

 

Mnemonic: Carbon dating puts dinosaur (other drug) in the uterus.

Term
Prostacyclin
Definition

PGI2 aka epoprostanol

 

-inhibits formation of platelet plug involved in primary hemostasis

Term
indomethacin
Definition

NSAID

 

COX 1 inhibitor

 

prodrug

 

-tx for failure of ductus closure

-be careful when giving to elderly due to neuro effects

 

One cocky (COX-I) premed might become a sullen doc (Sulindac) when they see what it takes to get into Medicine (Indomethacin). It's enough to make your stomach walls drop (Gastric erosion).

Term
sulindac
Definition

NSAID

 

Cox 1 inhibitor

 

prodrug

 

One cocky (COX-I) premed might become a sullen doc (Sulindac) when they see what it takes to get into Medicine (Indomethacin). It's enough to make your stomach walls drop (Gastric erosion).

Term
diclofenac
Definition

NSAID


COX1 inhibitor

Term
ibuprofen
Definition

NSAID

 

Both COX 1 + COX 2 antagonist

 

Mnemonic: I bring proof (Ibuprofen), that if you keep up all this cox-blocking (COX-I &II), you'll 'make no friends or mates' (Meclofenamate).

Term
meclofenamate
Definition

NSAID


COX 1 + COX 2 inhibitor

 

Mnemonic: I bring proof (Ibuprofen), that if you keep up all this cox-blocking (COX-I &II), you'll 'make no friends or mates' (Meclofenamate).

Term
Naproxen
Definition

NSAID

 

Aleve

 

COX 1 inhibitor

Term
Piroxicam
Definition

long acting NSAID

 

half life is ~ 37 hours

 

both COX 1 + COX 2 inhibitor

Term
nabumetone
Definition

NSAID

 

Partial COX 2 antagonist

 

Two (COX-II) toxic Coxib sibs, Val and Vioxx (Valdecoxib & Rofecoxib/Vioxx), went on to break hearts, but nobody mentions (Nobumentone) Cele, who was good from the start.

Term
celecobix
Definition

NSAID 


COX 2 antagonist

 

only one of the "coxib" family safe for use

 

Two (COX-II) toxic Coxib sibs, Val and Vioxx (Valdecoxib & Rofecoxib/Vioxx), went on to break hearts, but nobody mentions (Nobumentone) Cele, who was good from the start.

Term
Valdecoxib
Definition

COX2 antagonist

 

taken off market due to increased cardiac adverse effects

 

Two (COX-II) toxic Coxib sibs, Val and Vioxx (Valdecoxib & Rofecoxib/Vioxx), went on to break hearts, but nobody mentions (Nobumentone) Cele, who was good from the start.

Term
Rofecoxib
Definition

COX 2 antagonist

 

taken off market due to increased cardiac adverse effects

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