Term
| Where are the genes encoding MHC Class I and II found? |
|
Definition
|
|
Term
| What are the 3 compartments of the MHC complex? |
|
Definition
Class I Genes
Class II Genes
Class III Genes (NK-receptors, TNF alpha/beta genes etc) |
|
|
Term
True or False
The MHC is found on the same chromosome across a wide variety of species |
|
Definition
False
Found on different chromosomes |
|
|
Term
True or False
Genes within the MHC complex are found in the same position across a wide variety of species |
|
Definition
|
|
Term
| What are the functional human MHC Class I Genes? |
|
Definition
|
|
Term
| What are the functional human MHC Class II genes? |
|
Definition
DP, DQ and DR with alpha & beta chain versions for each
e.g. DRB = DR beta |
|
|
Term
| How is the porcine MHC complex different from humans? (3) |
|
Definition
Class II and Class III genes are separated by the centromere on Ch7
pigis only have 3 functional Class Ia genes
pigs express Class II DR and DQ but not DP |
|
|
Term
| What Class II genes do pigs not express? |
|
Definition
|
|
Term
| How many class Ia genes do pigs have? How many are functional? |
|
Definition
|
|
Term
| HLA is to humans as ____ is to pigs |
|
Definition
|
|
Term
| How is the bovine MHC complex different from humans? |
|
Definition
-have Class IIa and IIb regions on ch23 due to an inversion
-do not express Class II DP
-have unique genes DYA, DYB and DI
-DQA, DQB and DRB are highly polymorphic
-6 class Ia genes, only 3 are functional |
|
|
Term
| How many class Ia genes do cows have? How many are functional? |
|
Definition
|
|
Term
| How many genes does the chicken MHC complex have? |
|
Definition
|
|
Term
| What chromosome is the bovine MHC complex found on? |
|
Definition
|
|
Term
| What chromosome is the porcine MHC complex found on? |
|
Definition
|
|
Term
| What chromosome is the chicken MHC complex found on? |
|
Definition
|
|
Term
| What are the two regions of the chicken MHC copmlex? |
|
Definition
|
|
Term
| What genes are expressed in the chicken MHC complex? |
|
Definition
|
|
Term
| Why are chickens potentially highly susceptible to viral infections? |
|
Definition
| they only have a single dominant Classs Ia gene which is highly polymorphic |
|
|
Term
| Describe the structure of the peptide-binding cleft of the MHC class Ia receptor |
|
Definition
| 2 alpha helices and a B sheet |
|
|
Term
| What factors affect the binding affinity of the Class Ia receptor? |
|
Definition
point mutations
reciprocal recombination
gene conversion |
|
|
Term
| The peptide binding cleft of a MHC Class II molecule is comprised of ... |
|
Definition
| alpha-1 and beta-1 domains of the alpha and beta chains |
|
|
Term
True or False
It is possible that each human has a unique HLA haplotype |
|
Definition
|
|
Term
| Which individual would be more likely to be resistant to disease, one with DPa/DPb genes or DPa/DPa? |
|
Definition
|
|
Term
| SLA alleles are associated with what disease? |
|
Definition
|
|
Term
| Chicken B21 is (resistant/susceptible) to Marek's disease |
|
Definition
|
|
Term
| Chicken B19 is (resistant/susceptible) to Marek's disease |
|
Definition
|
|
