Term
| What are the 3 main 'questions' to answer when diagnosing cancer? |
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Definition
What is it
Where is it
How bad is it (staging) |
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Term
| Which has a better prognosis, B cell or T cell lymphosarcoma? |
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Definition
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Term
| Characteristics of benign tumours |
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Definition
-localized
-non invasive
-often encapsulated |
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Term
| What are some immnotherapeutic agents used to treat non-hodgkins lymphoma? How does this work? |
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Definition
AT-004 & AT-005
monoclonal antibodies which will target B cells or T cells which express CD20 (95% of malignant cells express this) |
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Term
| What are some agents used to treat cancer using gene therapy? |
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Definition
tyrosinase
s100
gp100
Melan-A |
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Term
| What are the checkpoints in place that normally regulate cell proliferation? |
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Definition
-if genome is damaged, won't enter S phase or DNA replication stops in 'S' until it is repaired
-if replication isn't completed, during G2, cell arrests
-cell arrested in M if chromatids don't attach to spindle properly |
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Term
| What is 'kit' and what does it do? |
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Definition
| kit is an oncogene which is upregulated by protein kinase in the plasma membrane, stimulating accelerated proliferation |
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Term
| What is a mast cell tumour? How might you treat this? |
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Definition
constitutive phosphorylation of KIT due to duplications in exons 11 & 12
can use tyrosine kinase inhibitors |
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Term
| What is the importance of p53 in cancer? |
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Definition
| this gene is abnormal in >50 of human cancers, and many canine and feline cancers as well |
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