Term
| Transferrin Receptors (TfR) |
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Definition
| Protein receptor complexes expressed on outer cell membranes which Transferrin attachess to when bound with 2 atoms of iron. |
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Definition
| A glycoprotein which binds 2 atoms of iron (becomign Diferric-Tf) in order to bring iron into the interior of cells. |
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Definition
| A protein coating the vesicle containing iron while in a cell. |
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Definition
| A membrane-bound compartment. When the endosome becomes acidified by proton pumps, iron attached to the TfR-Tf complex is released. And then exported out of the dosome by DMT1. |
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Term
| DMT1 (Divalent Metal Transporter 1) |
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Definition
| Exports Iron when the endosome becomes acidic. |
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Definition
| An intracellular protein that stores iron in the body when it is not needed for iron demands. |
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Definition
The term for transferrin without any iron bound to if |
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Definition
Fluid-phase endocytosis; the plasma membrane of the cell infolds brigin extracellular fluid and solutes into the interior of the cell.
A form of active transport (ion pumps, Na/K ATPase) |
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Term
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Definition
The process by which substances from the cell interior are moved to the extracellular space. Vesicles with the substance to be externalized fuse with the cell membrane and secrete the substance to the exterior.
A form of active transport (ion pumps, Na/K ATPase) |
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Definition
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Definition
The process of a cell absorbing a particle through engulfing it.
The cell engulfs a large particle by forming projecting psudopods ("false feet") around it and enclosing it within a membrane sac called a phagosome. The phagosome is combined with a lysosome for digestion of its contents. Undigested contents either remain in the vesicle (now called a residual body) or are rejected by exocytosis. |
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Term
| Receptor-mediated endocytosis |
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Definition
| Extracellular substances bind to specific receptor proteins inthe coated pits, enabling the cell to ingest and concentrate specific substances (ligands) in protein-coated vesicles. Ligands may later simoly be released inside the cell or combined with a lysosome to digest the contents. The receptors are recycled to the plasma membrane in vesicles. |
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Term
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Definition
| Specialized regions of a cell's membranes composed of pits coated with a protein (usually clathrin). These pits are the entry route for macromolecules bound by cell surface receptors. These pits and the attached macromolecules are then internalized into the cytoplasm to form coataesd vesciles. |
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