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protests the nervous system and is divided into two subdivisions: cranial cavity (encases the brain) and the vertebral cavity (encases the spinal cord) |
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houses the internal organs (viscera) and is divided into two subdivisions: thoracic (heart & lungs) and the abdominopelvic which is further divided into the abdominal cavity (digestive viscera, e.g. stomach) and the pelvic cavity (bladder & some reproductive organs) |
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Ventral Body Cavity Membranes |
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- Parietal serosa lines the internal body walls
- Visceral serosa covers the internal organs (i.e. visceral --> viscera)
- Serous fluid separates the serosae, preventing friction caused by organs rubbing against each other
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Organ Systems: Integunentary |
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- Provides protection, heat, defensem, and endocrine
- Includes: skin, hair, nails, sweat/oil glands
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Provides protection, locomotion, and metabolic activities
Includes: bones, joints, cartilage, ligaments, & bone marro |
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Provides movement, heat, and posture
Includes skeletal muscles, tendons, and aponeuroses |
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Collects and processes information
Includes brain, spinal cord, nerves, and sensory organs |
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Provides communication, regulation and integration of body systems
Inclues: hypothalamus, pituitary, pineal body, thyroid, parathyroids, adrenal glands, thymus, ovary testis, pancreas |
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Organ Systems: Cardiovascular |
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Functions to pump blood to and from the body.
Includes: heart, blood, arteries, veins, capillaries |
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Organ Systems: Respiratory |
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Functions to exchange gas, supply oxygen and to remove carbon dioxide
Includes: nasal cavity, pharynx, larync, trachea, bronchi, and lungs |
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Provides fluid balance, electrolyte balance, and excreation of waste products
Includes: kidneys, ureters, bladder, and urethra |
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- Isolates cellular contents from external environment; provides mechanism to control constant intracellular environment
- Outer surface can adhere to the extracellular matirx and other cells through integrins (transmembrne proteins)
- Plasma membrane interacts with cytoskeletal elements to determine cell shape and movement
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- Proteins receptors that mediate attachment b/t a cell and the tissues surrounding it.
- Integrins also play a role in cell signal transduction.
- Allows the plasma membrane to adhere to the extracellular matrix.
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extracellular environment - interstital fluid |
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- Contains many substances need by the body; substances produced as waste and being transported elsewhere; or substances ingested or exposed to it; it bathes and surrounds the cells
- Similar composition to plasma
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Internal Environment - Cytoplasm |
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- Material between the cell membrane and nucleus:
- Cytosol
- Cytoplasmic organelles
- Inclusions (non-living substances including nutrients, lipid droplets, melanin, etc.)
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Membrane Junction: Tigh Junction |
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- A junction in which the plasma membranes of adjacent cells fuse together.
- Attach by interlocking junctional proteins.
- It is an "impermeable" junction
- Most minerals absorbed by the body are transferred through the tight junctions of the intestinal cells.
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Membrane Junctions: Desosome-Anchoring |
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- Junction scattered along the sides of cells; found in cells that are subjected to pulling forces
- Integrin protein link
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Membrane Junctions: Gap Junction |
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- A nexus that allows chemical substances to pass between cells
- A channel forms b/t neighboring integrin proteins.
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- A Lysososmal Storage Disease
- A recessive genetic disorder that results in insufficient activity of the lysosomal enxyme hexosaminidase A which catalyzes the biodegradation of lipids
- Nerve cells become distended with gangliosides which is visible as a large red spot in the back of the eye. Gangliosides accumulates in the brain and causes cell death
- A loss-of-function disease, often due to a mutation in a protein that impacts: balance in protein folding, trafficking, degradation, and alters protein homeostasis
- Patients with TSD become blind, deaf, cannot swallow, have muscle paralysis, and infants have an increased startle reflex.
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A genetic disorder in which there is a multation in the ABCD1 gene that encodes a peroxisomal membrane transporter.
- People with ALD accumulate high levels of saturated bery long chain fatty acids in the brain and adrenal cortex.
- There is progressive myelin dmage and destruction.
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