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lec 1
tissue specialization
19
Biology
Undergraduate 3
12/11/2007

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Term
epithelial tissue
Definition
polarized: side that faces "inside" (basolateral membrane-- toward the blood) and side that faces "outside"(apical membrane)

basement membrane- runs along the basal part of the membrane

have tight junctions-- prevent stuff from moving from one side to the other. when there is a break at a tight junction blood can cross to the outside (ie. when you get a cut)

FUNCTION: covers entire surface, protects underlying tissue, specialized junctions (tight junctions), secretion, absorption, protective

TYPES: Squamous, cuboidal, columnar
Term
squamous
Definition
epithelial tissue-- flat cells with an irregular flattened shape

stratified squamous: mucous membranes lining the inside of the mouth, the esophagus, part of rectum

simple squamous: open to outside body cavities, one cell layer-- lungs (alveoli)
Term
cuboidal
Definition
epithelial tissue- shaped like a cube, nuclei of cells located near the center

simple cuboidal- kidney-- collecting duct (secretion)
Term
columnar
Definition
epithelial tissue- taller than they are wide, nucleus close to base of cells

simple columnar: small intestine (absorption)
Term
tight junction
Definition
specialized adjoining junctions between epithelial cells

link between cells, prevents outside from readily communicating with the inside (blood side)

break in tight junction is only way blood is able to cross to the outside (like when you get a cut)
Term
connective tissue
Definition
involved in structure and support, hold you together (neck, knees, etc)

TYPES: structural, sequestering, defensive
Term
structural
Definition
type of connective tissue-- fibroblasts, chondrocytes, osteocytes are cells producing structural tissue

EXAMPLES: bone, cartilage, loose and fibrous connective tissues (osteocytes, chondrocytes, fibroblasts)

Fibroblasts: secrete important proteins- collagen/elastin (skin)

collagen fibers- series of protein twisted over several structural levels to make a very strong cable (25% of body is collagen)

elastin- an elastic protein that can be stretched and relaxed

bones: living tissues with a blood supply. have osteoblasts (secrete bone matrix) and osteoclasts (erode bone matrix)
Term
sequestering
Definition
connective tissue that includes adipose (fat) tissue and red blood cells

blood is a connective tissue consisting of cells and plasma, all blood cells come from 1 stem cell (PLURIPOTENT STEM CELLS) from bone marrow-- constantly makes/destroys red blood cells

red blood cells- last ~3months/90days
Term
defensive
Definition
connective tissue that includes white blood cells

defensive against outside invaders

macrophages, lymphocytes, mast cells
Term
sources of stem cells
Definition
1. inner cell mass of early embryonic human blastocysts

2. endogenous (adult) stem cells isolated from tissues (eg. blood marrow, fat tissue, intestinal epithelia)

3. umbilical cord blood of newborn infant (can take blood from chord and store it to be used as stem cells later)
Term
connective tissue diseases
Definition
-vitamin c- scurvy: defective collagen synthesis

-vitamin d- Ca2+ absorption and normal bone growth, osteomalacia: Ca2+ deficiency--rickets

-vitamin a- normal bone growth

-osteoporosis- loss of bone mineral, esp. in aged/postmenopausal women

**-Ehler-Danlos syndrome- hereditary defect of collagen synthesis, very flexible joints "india rubber man"

**-Osteogenesis Imperfecta- improper development of more rigid collagenous structure, tendons thin and subject to rupture

**hereditary
Term
muscle tissue
Definition
possess proteins of contraction: actin/myosin

TYPES: skeletal, smooth, cardiac
Term
skeletal muscles
Definition
muscle tissue

voluntary muscles of the body, highly organized filaments

eg. muscles you think of when you go to the gym/lift things
Term
smooth muscles
Definition
muscle tissue, earliest form, found throughout animal kingdom

muscle that you cannot control, found in lining of digestive tract and blood vessels

told to contract by an involuntary center in your brain
Term
cardiac muscle
Definition
muscle tissue

involuntary, able to generate its own contractile pacemaker (can be modified by info from the brain)

highly adapted as a pump
Term
contractile proteins
Definition
actin, myosin

proteins that allow muscle tissues to contract
Term
nervous tissue
Definition
cells of nervous tissue able to become excited, conduct a message, transmit the message to the next cell in the circuit

important for communication, control of all the body's functions

COMPOSITION: neurons and support cells

NEURONS: dendrites, body, axon
Term
organ systems
Definition
digestive- eating food and transporting pieces to the blood

cardiovascular- blood circulation for oxygen and nutrient delivery and waste removal

respiratory- takes oxygen from the atmosphere and delivers it to red blood cells in the blood

excretory- removes waste from the blood and deposits it outside the body

endocrine- chemical signaling system for various processes

reproductive- system to make gametes and develop progeny

*skeletal- structural system

muscular- allows locomotion, circulation, digestion

nervous- receives sensory info and responds to environment

immune- protects body from invading viruses and organisms

*integumentary- skin, protective barrier from outside world

*don't need to know much about
Term
homeostasis
Definition
principle of maintaining/regulating the internal environment when something changes

interaction between organ systems maintains constancy

ex. body temperature--b/c all proteins optimized to work at 37 degrees, if moves too far away...proteins can denature-- body overheats:sweat, body too cold: shiver

Negative Feedback: mechanism of Homeostasis--doing something that will eventually turn it "off"
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