Term
| Anticyclic-citrullinated peptide antibody is found in the early stages of Rheumatoid Arthritis and may be present even when the rheumatoid factor is absent. |
|
Definition
| Anti-CCP antibody (<5 units/ml) |
|
|
Term
| This test is very specific for Systemic Lupus Erythematosus. This antibody is rarely found in other diseases. It is not a very sensitive test for SLE. |
|
Definition
| Anti-double stranded DNA Antibody [Anti-dsDNA] (negative) |
|
|
Term
| Positive: Systemic Lupus Erythematosus Chronic Hepatitis Infectious mononucleosis |
|
Definition
| Anti-double stranded DNA Antibody [Anti-dsDNA] (negative) |
|
|
Term
| The presence of antinuclear antibodies is an indicator of connective tissue disorders in general. Almost all patients with SLE develop antinuclear antibodies; a negative ANA excludes the diagnosis of SLE [sn 100% and sp 68%]. |
|
Definition
| Antinuclear Antibody [ANA or fANA] (negative) |
|
|
Term
| Systemic Lupus Erythematosus [+ in 98% of patients] Scleroderma [+ in 60% of patients] Rheumatic Arthritis [+ in 30-50% of patients] Other connective tissue diseases such as dermatomyositis |
|
Definition
| Antinuclear Antibody [ANA or fANA] (negative) |
|
|
Term
| Rheumatic Fever Scarlet fever Acute glomerulonephritis Strep sore throat Toxic Shock Syndrome Impetigo |
|
Definition
| Antistreptolysin-O Titer [ASOT] (<160 Todd units) |
|
|
Term
| Increase: Gout Renal failure Leukemia Multiple myeloma Burns Dehydration Starvation Increased purines in the diet |
|
Definition
| Uric Acid (2.0-7.0 mg/dL) |
|
|
Term
| Increase: Rheumatoid arthritis [70% of RA patients have a + RF] Systemic Lupus Erythematosus Multiple myeloma Tuberculosis Sarcoidosis Liver disease Syphilis Infectious mononucleosis Sjögren’s syndrome [dry eyes and dry mouth] |
|
Definition
| Rheumatoid Factor [RF] (<1:20) |
|
|
Term
| Ankylosing Spondylitis [90%] Reiter’s syndrome [80%] Rheumatoid arthritis [8%] Inflammatory Bowel Disease [3%] Psoriasis [5%] |
|
Definition
|
|
Term
| Decrease: Liver failure Lead poisoning Wilson’s disease [excessive copper absorption causing Kayser Fleischer rings of copper deposits in the edges of the cornea and cirrhosis] |
|
Definition
| Uric Acid (2.0-7.0 mg/dL) |
|
|
