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Lab 12: Cardiovascular System
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62
Biology
Undergraduate 3
12/08/2014

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Term
7 Functions of the Cardiovascular System
Definition
1. gaseous exchange
2. delivery of major nutrients, building materials, and micro nutrients to tissues and organs.
3. Delivery of hormones from endocrine glands to distant target tissues.
4. Defense
5. Thermal Exchange
6. Transports Water around body
7. Removal of waste metabolites from tissues/organs
Term
Systemic Circuit
Definition
left heart pumps oxygenated blood through rest of the body via aorta and returns blood to right heart via superior and inferior venae cavae.
Term
Pulmonary Circuit
Definition
consists of deoxygentated blood and receives it from the right heart and pumps it to the lungs.
Term
How are systemic circuits arranged?
Definition
Arranged in parallel. Wide latitude for altering blood flow through a particular organ without altering flow through other parts of the system. This prevents cutting back of blood supply to each organ.
Term
3 basic layers of walls in blood vessels
Definition
1. tunica intima: inner layer of specialized squamous epithelium
2. tunica media: middle layer; smooth muscle fibers/elastic connective tissue
3. Tunica adventita: outer layer of connective tissue with elastic and collagenous fibers
Term
These do not have have smooth muscle fibers
Definition
non-muscular venules and capillaries
Term
Vasoconstriction
Definition
constriction of blood vessels with help of release of hormones: norepinephrine, epinephrine which are released from adrenal glands by sympathetic stimulation
Term
Vasodilators
Definition
dilates blood vessels, NITRIC OXIDE and HISTAMINE. Released by mast cells of connective tissue in response to injury to tissue.
Term
Vasodilators and Vasoconstrictors Control?
Definition
1. Flow of Blood through organs and tissues.
2. Resistance of the systemic circuit (TPR)
3. Total Capacity of the Blood vessels in the cardiovascular system
Term
Blood Pathway
Definition
superior vena cava to right atrium to tricuspid valve to right ventricle to pulmonary semilunar valve to pulmonary trunk to pulmonary artery to lungs to lobar branches to pulmonary capillaries to pulmonary vein to left atrium to bicuspid valve to left ventricle to aortic semilunar valve to aorta to body
Term
6 types of blood vessels
Definition
1. Arteries
2. arterioles
3. terminal arterioles
4. capillaries
5. venules
6. veins
Term
Artieres
Definition
made of tunica media which makes up wall
Term
arterioles
Definition
control blood flow through organs and tissues and determine TPR
Term
terminal arterioles
Definition
structures that are intermediate between arterioles and capillaries
Term
capillaries
Definition
consist of vascular endothelium only. smooth muscle fibers encircle it.
LACK TUNICA ADVENTICA and TUNICA MEDIA
Term
venules
Definition
blood passes from capillaries into venules which merge to veins.
NON MUSCULAR VS MUSCULAR
Term
veins
Definition
return blood to complete circuit
-hold large volumes of blood at low pressures. Contain valves and have large diameter with little elasticity
Term
Arteries branching from aorta (aortic arch)
Definition
Brachiocephalic - branches to RSubClav/RCC
Left Common Caroitd
Left Subclavian
Term
carotid arteries supply
Definition
head and neck region
Term
subclavian
Definition
branches into axillary artery ---> brachial of upper arm ----> radial/ulnar of lower arm
Term
Descending Aorta
Definition
-Rise to small arteries that supply thoracic wall and thoracic organs
Term
Abdominal Aorta below diaphragm is
Definition
Celiac Artery
Term
Celiac Artery branches too
Definition
Splenic Artery (spleen)
Hepatic Artery (Liver/gallbladder)
Superior Mesenteric (intestinal tract)
Inferior Mesenteric (Colon/Rectum)
Renals (kidneys
Gonadals (ovaries/testes)
Term
Right/left common iliacs branch to
Definition
external and internal iliacs.
Term
External iliacs branch to
Definition
arteries of legs, femorals, popliteal, and the anterior/posterior tibials.
Term
Blood in leg drained by
Definition
anterior/posterior tibials, femoral vein, great saphenous vein.

All empty into external iliac/internal iliac which drains to common iliac.
Term
These drain into inferior vena cava
Definition
Renals, Gonadals, Hepatic
Term
Lower arm blood drains into
Definition
radial and ulnar veins which empty into brachial of upper arm which drains into axillary which drains to subclavian which drains into brachiocephalic which empties into superior vena cava.
Term
Head/Neck Regions
Definition
drained by internal and external jugulars and empty into subclavians which becomes brachiocephalic.
Term
Structure of Capillary Bed
Definition
Consist of arterioles, terminal arterioles, capillaries, and venules. Both muscular and non-muscular venules.
Term
Precapillary Sphincter
Definition
contraction and relaxation can control the flow of blood into the capillary
Term
What supplies capillary bed
Definition
arteries
Term
What takes blood away
Definition
veins
Term
3 Layers of Heart
Definition
1.Epicardium= outer layer aka visceral pericardium
2. Myocardium= middle layer (interlacing bundles of cardiac muscle fibers and heart acts as a very efficient pump)
3. Endocardium= inner layer that lines cavities of heart. consists of a thin layer of vascular endothelial cells overlying thin layer of connective tissue.
Term
Opening and closing of valves is..
Definition
Purely Passive and occurs in response to changing pressure differentials across them.
Term
Tricuspid Valve
Definition
(3 leaflets) chordae tendinae connect pointed ends of the leaflets to fingerlike muscular projections (papillary muscles) on inner surface of the right ventricle
Term
Pulmonary Semilunar Valve
Definition
guards opening from right ventricle into pulmonary trunk
Term
Bicuspid Valve
Definition
2 cusps; chordae tendinae attached to papillary muscles on inside of left ventricle
Term
Aortic Semilunar valve
Definition
guards opening of left ventricle to aorta
Term
Vessels entering/leaving heart
Definition
Superior Vena Cava- deoxygentated blood
Pulmonary Artery- deoxygenated blood
Pulmonary Vein- oxygenated blood
Aorta- oxygenated blood
Term
Coronary Circulation of Heart
Definition
Right and left coronary arteries branch from aorta just distal to aortic semilunar valve
Term
left coronary artery
Definition
supplies blood to left atrium and both ventricles
Term
right coronary artery
Definition
supplies blood to right atrium and both ventricles
Term
Blood drains into
Definition
cardiac veins
Term
cardiac veins empty to
Definition
cardiac sinus
Term
cardiac sinus drains into
Definition
right atrium
Term
vasomotor
Definition
central control of heart in medulla region
Term
what does the vasomotor do?
Definition
output from this center controls both sympathetic outflow to the heart and the flow of nerve impulses down the vagus nerve
Term
Sympathetic characteristics
Definition
1. Accelerates Heart Rate
2. Increase Force of Contraction of Ventricular Myocardium
3. Norepinephrine is released at sympathetic nerve terminals and acts on Beta adrenergic receptors in pacemaker cells of SA node and on cardiac muscle cells of ventricles
Term
Parasympathetic characteristics
Definition
1. Slows heart rate (SA Node)
2. Does not alter force of contraction of ventricles b/c it does not innervate them
3. Acetylcholine released at parasympathetic nerve terminals and acts on nicotinic receptors which binds to muscarinic receptors in pacemaker cells of SA node.
Term
Muscarinic Receptors blocked by
Definition
Atropine
Term
Chronotropic effect
Definition
sympathetic nervous system increases heart rate, while parasympathetic nervous system decreases heart rate
Term
Norepinephrine
Definition
neurotransmitters released by postganglionic nerve terminals in the heart
Term
Epinephrine
Definition
released by preganglionic sympathetic nerve fibers
Term
Alpha Adrenergic Receptors
Definition
on smooth muscle cells of blood vessels
Term
Beta Adrenergic receptors
Definition
receptors found in heart and gastrointestinal smooth muscle.
Term
acetylcholine
Definition
parasympathetic neurotransmitter that binds to nicotine and muscarinic receptor in plasma membrane of target cells
Term
propranolol
Definition
Beta blocker (slows down heart rate)
Term
phentholamine
Definition
Alpha adrenergic receptor blocker
Term
verapamil
Definition
calcium channel blocker
Term
digitalis
Definition
increase intracellular calcium levels causing increase in myocardial contractility. Helps for failing heart
Term
Calcium's importance in contraction for cardiac muscle
Definition
rise of intracellular calcium leads to contraction of cardiac muscle. Stored in sarcoplasmic reticulum and released during plateau phase of cardiac action potential.
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