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Neutrofil suka ciałko Barr |
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Neutrofil pałeczkowaty pies 2/3 w najszerszym miejscu |
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Pałki pies, toksyczne septyczne zapalenie otrzewnej |
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Pałki kot + ciałka Heinza zapalenie, jądra w kształcie pączka Cukrzyca i grzybica płuc |
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Neutrofil olbrzymi, reakcja białaczkowata Kot z infekcją bakteryjną |
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Hipersegmentacja >5 segmentów Szczególnie zapalenie przewlekłe i GKS Także białaczki Rzadziej niedobór kobalaminy i folianów |
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Bazofil Psi bez ziarnistości 1.Największe z granulocytów 2.Cytoplazma ciemna 3.Jądro jak wstęga |
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Monocyt L , neutrofil segmentowany P pies Jeżeli nie ma zmian toksycznych to komórka z szaro niebieską cytoplazmą i pałeczkowatym jądrem to monocyt! + 1.często końce mono przypominają klamkę 2.Chromatyna jądrowa nie jest grudkowata |
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Monocyt L, bazofil P pies ciężka inwazja pcheł |
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Monocyt erytrofagocytoza pies |
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Monocyt z kwasochłonnymi ziarnistościami pies |
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Monocyt z hemosyderyną pies |
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Proerytroblast Duży okrągły Duże jądro Ciemnoniebieska (granatowa) cytoplazma Chromatyna drobnogrudkowa Jedno lub dwa jąderka, wyniesione często niebieskawe |
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Proerytroblast Duży okrągły Duże jądro Ciemnoniebieska (granatowa) cytoplazma Chromatyna drobnogrudkowa Jedno lub więcej jąderek, wyniesione często niebieskawe |
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Erytroblast Nieco mniejszy Cytoplazma ciemnoniebieska BRAK JĄDEREK |
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neutrofil toksyczny 1. Bazofilia 2. Ziarnistości - ciałka dohla 3. Wakuolizacja |
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neutrofil toksyczny 1. Bazofilia 2. Ziarnistości - ciałka dohla 3. Wakuolizacja |
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neutrofil toksyczny 1. Bazofilia 2. Ziarnistości - ciałka dohla 3. Wakuolizacja |
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neutrolfil hipersegmentowany |
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Monocyty lewa góra i prawy dół Pałka lewy dół Toks neutr prawa góra Monocyty zwykle większe, cytolazma bardziej bazofilna, jądro bardziej regularne Nie muszą być zwakuolizowane |
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Monocyt Monocyty zwykle większe, cytolazma bardziej bazofilna, jądro bardziej regularne |
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one a band neutrophil (lower left) and the other a metamyelocyte (arrowhead) with a kidney-bean shaped nucleus and the same cytoplasm as the band neutrophil. A monocyte is also evident and differs from the two immature neutrophils by a more uniformly blue-gray cytoplasm, discrete margined cytoplasmic vacuoles and lighter chromatin (less heterochromatin). In contrast, the two immature neutrophils resemble each other (nuclear, cytoplasm features) more than they resemble the monocyte. Both are toxic, with cytoplasmic basophilia and toxic granulation, indicating an inflammatory leukogram |
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Szare eozynofile mniejsze niż monocyt, dość okrągłe i podobnej wielkości granule, jądro segmentowane |
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Limfocyt reaktywny, ciemny |
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Limfocyt reaktywny, ciemny |
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Limfocyt atypowy wyraźne jąderka |
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Limfocyty atypowe nie ma jąderek są grudki chromatyny |
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Bazofilia u kota z mastocytozą układową |
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Monocyt psi Monocytes are usually larger than lymphocytes and have nuclei that are more variable in shape and have N : C ratios of 1.0 or less. The monocyte nucleus may be round, kidney-shaped, band-shaped, or convoluted (ameboid) with chromatin that is diffuse or mildly clumped. The cytoplasm is typically blue-gray and often contains variably sized vacuoles. |
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Monocyt psi If no toxicity is present, the cells with band-shaped nuclei and blue-gray cytoplasm are identified as monocytes. Other potentially helpful criteria include the following: the ends of the band-like nucleus of the monocyte are often enlarged and knob-like and the nuclear chromatin of the monocyte is not clumped in the dark-light pattern to the degree commonly seen in band neutrophils. |
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Monocyt psi If no toxicity is present, the cells with band-shaped nuclei and blue-gray cytoplasm are identified as monocytes. Other potentially helpful criteria include the following: the ends of the band-like nucleus of the monocyte are often enlarged and knob-like and the nuclear chromatin of the monocyte is not clumped in the dark-light pattern to the degree commonly seen in band neutrophils. |
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Monocyt psi If no toxicity is present, the cells with band-shaped nuclei and blue-gray cytoplasm are identified as monocytes. Other potentially helpful criteria include the following: the ends of the band-like nucleus of the monocyte are often enlarged and knob-like and the nuclear chromatin of the monocyte is not clumped in the dark-light pattern to the degree commonly seen in band neutrophils. |
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Monocyt psi. Less often, dust-like pinkish or reddish purple granules may be visible in the cytoplasm |
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Monocyt kota In some disorders, mononuclear phagocytes in blood become activated and enlarged, resembling macrophages Macrophage in blood from a cat with Mycoplasma haemofelis infection. Lower |
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Monocyte (left) and a reactive lymphocyte with intensely basophilic cytoplasm (right) in blood from a dog after vaccination. The N : C ratio is typically greater than 1.0 for large lymphocytes. Monocytes must also be differentiated from large reactive lymphocytes with convoluted nuclei. The cytoplasm of reactive lymphocytes is more basophilic (navy blue in color) than the cytoplasm of monocytes |
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Band neutrophil (left) and neutrophilic myelocyte (right) in the blood of a dog with Pelger-Huët anomaly. |
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Left shift in the blood of a dog with chronic myeloid leukemia. Band neutrophils, neutrophilic metamyelocytes, and a neutrophilic myelocyte are present. |
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Band neutrophil (left), bilobed neutrophil (center), and eosinophilic myelocyte (right) in the blood of a cat with Pelger-Huët anomaly |
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Type I myeloblasts appear as large round cells with round to oval nuclei that are generally centrally located in the cell. The N : C ratio is high (more than 1.5), and the nuclear outline is usually regular and smooth Nuclear chromatin is finely stippled, containing one or more nucleoli or nucleolar rings. The cytoplasm is generally moderately basophilic but not as dark as rubriblasts. Some myeloblasts may contain a few (less than 15) small magenta-staining granules in the cytoplasm and may be classified as type II myeloblasts Myeloblasts with numerous magenta-staining granules are classified as type III myeloblasts Jasne jąderka cytoplazma niebieska mogą być ziarnistości Duża szansa na białaczkę |
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Promyelocytes or progranulocytes have round to oval nuclei with lacy to coarse chromatin. Their most identifiable characteristic is the presence of many magenta-staining primary granules within light-blue cytoplasm. Większe niż mieloblasty, jądro duże, ale mniejsze niż w mieloblaście. Położone ekscentrycznie,chromatyna jądrowa bardziej skondensowana, średnio lub grubogrudkowa, przejaśnienie przyjądrowe. Często widoczne jąderka. |
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Myelocytes have round nuclei but they are generally smaller with more nuclear condensation and lighter-blue cytoplasm than promyelocytes. Nie ma już ziarnistości pierwotnych, są wtórne. Mniejsze od promielocytów, jądro ekscentryczne, owalne lub okrągłę, możę mieć lekkie wcięcie do 25%, chromatyna drobnogrudkowa |
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Nuclei with slight indentations are still classified as myelocytes, but once the nuclear indentation extends more than 25% into the nucleus, the cell is called a metamyelocyte. Nuclear condensation becomes readily apparent at this stage of maturation. Cytoplazma jaśniejsza, mniejszy od mielocyta |
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Neutrofil pałeczkowaty S-kształt |
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Histoplasma capsulatum organisms in the cytoplasm of a dog neutrophil. |
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Mycobacterium organisms in the cytoplasm of a neutrophil in blood from a dog. These organisms do not stain; they appear as linear clear areas. |
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Toxic and degenerative neutrophil with multiple intracellular Francisella philomiragia organisms in a dog with septicemia and disseminated intravascular coagulation (DIC). |
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Bacterial cocci phagocytized by a neutrophil in blood from a dog with urolithiasis, pyelonephritis, and septicemia. Staphylococcus intermedius was cultured from blood and urine. |
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Bacterial rods phagocytized by a neutrophil in a buffy coat smear prepared from blood from a cat with a leukopenia and septicemia |
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Two Anaplasma phagocytophilum (formerly Ehrlichia phagocytophila) morulae in the cytoplasm of a neutrophil in blood from a goat |
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Anaplasma phagocytophilum (formerly human granulocytic Ehrlichia) morulae in the cytoplasm of a neutrophil in blood from a dog from Minnesota. |
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Ehrlichia ewingii morula in the cytoplasm of a neutrophil in blood from a dog. |
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Three reddish distemper inclusions in the cytoplasm of a neutrophil in blood from a dog with canine distemper. Diff-Quik stain |
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May-Hegglin anomaly in a dog. A neutrophil with two large blue fusiform cytoplasmic inclusions (left) and a macroplatelet (macrothrombocyte) are present Mopsy makrotrombocytopenia inkluzje w WBC bezobjawowe |
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Neutrophil with large cytoplasmic granules in blood from a Persian cat with Chédiak-Higashi syndrome |
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Neutrophil with reddish cytoplasmic granulation in blood from a Siamese cat without clinical signs attributable to a lysosomal storage disease |
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Neutrophil with cytoplasmic granules in the blood of a korat cat with inherited GM2-gangliosidosis |
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Neutrophil with cytoplasmic granules in the blood of a korat cat with inherited GM2-gangliosidosis |
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Neutrophil with cytoplasmic granules in the blood of a 3-month-old German shepherd dog with inherited mucopolysaccharidosis type VII. |
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Neutrophil with cytoplasmic granules in the blood of an 8-month-old domestic shorthair cat with inherited mucopolysaccharidosis type VII |
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Neutrophil with cytoplasmic granules in the blood of a 1-year-old domestic shorthair cat with inherited mucopolysaccharidosis type VI. |
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Döhle bodies in the cytoplasm of a neutrophil in blood from a cat without other cytoplasmic evidence of toxicity. |
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Toxic neutrophilic metamyelocyte with foamy basophilia and faintly staining Döhle bodies in the cytoplasm in blood from a cat with a leukemoid reaction secondary to a bacterial infection that resulted in the formation of multiple draining abscesses |
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Toxic band neutrophil with foamy basophilia and Döhle bodies in the cytoplasm in blood from a cat with septic peritonitis |
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Toxic neutrophil with foamy basophilia and Döhle bodies in the cytoplasm in blood from a cat with a marked left shift (leukemoid reaction) secondary to a bacterial infection that resulted in the formation of multiple draining abscesses |
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Toxic neutrophil with foamy basophilia and Döhle bodies (angular blue inclusions) in the cytoplasm in blood from a cat with septic peritonitis |
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Toxic metamyelocyte with foamy basophilia of the cytoplasm in blood from a cat with septic peritonitis. |
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Neutrophil with donut-shaped nucleus and foamy basophilia (toxicity) of the cytoplasm in blood from a horse with a Babesia equi infection. |
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Neutrophil with foamy basophilia (toxicity) of the cytoplasm in blood from a cat with septic peritonitis |
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Neutrophil containing a Leishmania infantum amastigote within its cytoplasm. Diff-Quik stain |
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Neutrophil with cytoplasmic granules in the blood of a 7-month-old miniature schnauzer dog with mucopolysaccharidosis type VI. |
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Neutrophil with siderotic cytoplasmic inclusions in blood from a horse with equine infectious anemia. |
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An inexperienced observer may confuse neutrophils with precipitated stain with basophils. When this artifact is unevenly distributed, other areas of the blood film can be found that stain normally |
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Giant neutrophil in blood from a cat with septic peritonitis. |
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Giant hypersegmented neutrophil in blood from a dog with lymphoma. Large neutrophils may occur in animals (especially cats) with inflammatory diseases and/or dysgranulopoiesis.226 They may exhibit normal nuclear morphology (Fig. 5-29, A) or appear hypersegmented (Fig. 5-29, B-C). Cytoplasmic toxicity may be prominent in inflammatory conditions (Fig. 5-29, D). Dysgranulopoiesis is seen in acute myeloid leukemias (AMLs), myelodysplastic syndromes, feline leukemia virus (FeLV) infections, and feline immunodeficiency virus (FIV) infections.425,490 Giant neutrophils have also been reported in blood secondary to other disorders including lymphoma, immune-mediated thrombocytopenia (IMT), immune-mediated hemolytic anemia (IMHA), and |
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Giant hypersegmented neutrophil in blood from a dog with lymphoma that is being treated with chemotherapy. |
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Giant toxic neutrophil in blood from a cat with diabetes mellitus and fungal pneumonia. |
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E, Toxic degenerate neutrophil exhibiting karyolysis (nuclear lysis) in blood from an FIV-positive leukopenic cat. The dissolution of the nucleus resulting in nuclear swelling and loss of affinity for basic dyes is referred to as karyolysis (Fig. 5-29, E). This degenerative change occurs outside the bone marrow. It is frequently observed in neutrophils present in septic exudates and may sometimes be observed in the mammalian blood |
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Pyknosis and karyorrhexis in a neutrophil in blood from a dog with acute lymphoblastic leukemia (ALL) Neutrophils that undergo programmed cell death (apoptosis) exhibit pyknosis and karyorrhexis.359 Pyknosis involves the shrinkage or condensation of a cell with increased nuclear compactness or density; karyorrhexis refers to subsequent nuclear fragmentation (Fig. 5-29, F). Pyknosis and karyorrhexis are degenerative changes that are often observed in nonseptic exudates. They may be seen in blood neutrophils that have had prolonged time in the circulation. Pyknotic neutrophils are reported in increased numbers in inflammatory and neoplastic disorders in humans.423 Neutrophil hypersegmentation and pyknosis were reported in a dog with amphetamine toxicity attributed to high body temperature and accelerated apoptosis. |
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Phagocytized eosinophil granules in horse neutrophils. Wright-Giemsa stain. |
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Basophil in blood from a dog. Granules in dog basophils generally appear purple and are not numerous enough to fill the cytoplasm. |
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Basophil in blood from a dog.The nucleus is ribbonlike in shape and few granules are present. Granules in dog basophils generally appear purple and are not numerous enough to fill the cytoplasm. |
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Band basophil in the blood of a dog with a basophilia Granules in dog basophils generally appear purple and are not numerous enough to fill the cytoplasm. |
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Degranulated basophil in blood from a dog with a basophilia. Degranulated basophils may have purple-staining cytoplasm in the absence of granules |
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Basophil in blood from a cat with light-lavender granules filling the cytoplasm and giving the nucleus a moth-eaten appearance. |
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Basophil in blood from a cat with light-lavender granules filling the cytoplasm and giving the nucleus a moth-eaten appearance. |
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Basophil in blood from a cat with a mixture of light-lavender and purple granules filling the cytoplasm. |
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Basophil with reddish purple granules filling the cytoplasm in blood from the same Siamese cat |
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1. Towarzyszy eozynofili 2. MCT szczególnie nie skórne 3. Thrombocytemia 4. U psów lymphoid granulomatosis płuc |
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Morphology of mast cells. A, Mast cell in blood from a cat with splenic mastocytosis. |
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Cytauxzoon felis schizont development in a large macrophage in blood from a cat. Note the small size of the erythrocytes compared to the macrophage in this low-magnification image. |
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Large mast cell with cytoplasmic vacuoles in addition to granules in blood from a dog with a noncutaneous mast cell neoplasm. |
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Large mast cell exhibiting erythrophagocytosis in blood from a cat with a noncutaneous mast cell neoplasm. |
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Limfocyt ziarnisty u kota |
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Reactive lymphocyte with intensely basophilic cytoplasm in blood from a cow infected with bovine leukemia virus. |
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Reactive lymphocyte with a convoluted nucleus and intensely basophilic cytoplasm in blood from a cat with a bacterial infection. |
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Reactive lymphocyte with a convoluted nucleus and intensely basophilic cytoplasm in blood from a dog with a mild cough. |
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Plasmacytoid lymphocyte with intensely basophilic cytoplasm in blood from a dog with babesiosis. |
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Plasmacytoid lymphocyte with intensely basophilic cytoplasm in blood from a horse with Anaplasma phagocytophilum infection |
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Lymphocyte containing Russell bodies in the cytoplasm in blood from a horse |
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Cytoplasmic granules, vacuoles, and inclusions in lymphocytes. A, Lymphocyte containing basophilic granules in the blood of a 3-month-old German shepherd dog with inherited mucopolysaccharidosis type VII. Wright stain. |
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One of many lymphocytes containing cytoplasmic vacuoles in blood from an 8-week-old foal with Corynebacterium equi pneumonia. Lymphocytes appeared normal after treatment and recovery. Wright-Giemsa stain. |
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Lymphocytes with cytoplasmic vacuoles in the blood of a Korat cat with inherited GM2-gangliosidosis |
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E, Lymphocytes with cytoplasmic vacuoles in the blood of a domestic shorthair cat with inherited Niemann-Pick disease type C. Wright-Giemsa stain. |
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Lymphocyte containing a Sarcocystic neurona organism in a lymphocyte |
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Neoplastic large granular lymphocyte in blood from a cat with large granular lymphoma. Note the large size of the granules compared to the normal granular lymphocyte |
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Blood from a bulldog with an inherited mucopolysaccharidosis with purple granules in a lymphocyte and a neutrophil. The general disorder was diagnosed using screening tests, but the specific type was not determined |
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Plasma cell with eccentric nucleus in blood from a dog with multiple myeloma. . |
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Mott cell in the blood of a dog with lymphoma and Mott cell differentiation |
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Definition
Three large granular lymphocytes in blood from a cat with an abdominal large granular lymphoma. |
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Definition
Chronic lymphocytic leukemia (CLL) in blood from a cat with normal-appearing lymphocytes |
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Definition
Nonneoplastic lymphocytosis in blood from a cow infected with bovine leukemia virus. Lymphocytes are medium to large in size with increased cytoplasmic basophilia |
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Definition
Chronic lymphocytic leukemia (CLL) involving normal-appearing small lymphocytes with scant cytoplasm in blood from a dog |
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Definition
Acute lymphoblastic leukemia (ALL) involving granular lymphocytes in blood from a dog. Lymphoblasts with fine nuclear chromatin and nucleoli are present. Some of these cells contain cytoplasmic granules |
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Definition
Chronic lymphocytic leukemia (CLL) involving granular lymphocytes with abundant cytoplasm in blood from a dog |
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Definition
Lymphoblast in blood from a dog with acute lymphoblastic leukemia (ALL). |
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Definition
Lymphoblast in blood from a cat with ALL. |
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Definition
Large lymphoblast in blood from a dog with lymphoma. |
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Definition
Large lymphoblast in blood from a cow with lymphoma. Wright-Giemsa stain. E, |
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Definition
Large heavily vacuolated neoplastic cell in blood from a dog with intravascular lymphoma. The cell type is uncertain; however, it was considered most likely to be of NK cell origin. |
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Definition
Lymphoblasts in blood from a dog with acute lymphoblastic leukemia (ALL). |
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Definition
A small normal-appearing lymphocyte and three large monocytoid neoplastic lymphocytes in blood from a cow with metastatic lymphoma. |
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Definition
Pleomorphic lymphoblasts in blood from a dog with a T lymphocyte lymphoma. |
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Definition
Plasmacytoid lymphoma in a dog.Blast cells in the blood tended to lyse, making morphologic identification difficult. |
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Definition
Plasmacytoid lymphoma in a dog. Lymph node aspirate smear demonstrating the plasmacytoid appearance of the neoplastic |
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Definition
Myeloblast in blood from a cat with erythroleukemia (AML-M6). This neoplastic cell has a round nucleus and gray-blue cytoplasm. Two nucleoli are visible in the right side of the nucleus. |
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Definition
Myeloblast in blood from a dog with myeloblastic leukemia (AML-M2). This cell may be classified as a type II myeloblast because it contains a few small magenta-staining granules in the gray-blue cytoplasm near the top of the cell. |
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Definition
C, Monoblast in blood from a dog with acute myelomonocytic leukemia (AML-M4). The nucleus is more irregular than typically seen in myeloblasts. |
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Definition
Rubriblast in blood from a cat with erythroleukemia (AML-M6Er). This neoplastic cell has a remarkably round nucleus with intensely basophilic cytoplasm. |
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Definition
Megakaryoblast in blood from a dog with megakaryoblastic leukemia (AML-M7). The neoplastic cell has a remarkably round nucleus with cytoplasm that contains almost imperceptible pink granules and vacuoles. |
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Definition
Megakaryoblast in blood from a dog with AML-M7. The neoplastic cell has a remarkably round nucleus with pinkish cytoplasm that contains vacuoles and has surface projections. |
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Definition
Neoplastic dendritic cell in blood from a dog with dendritic cell leukemia. |
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Definition
Giant nonhematopoietic neoplastic cell in blood from a dog with widespread metastasis. Although this tumor was highly anaplastic, a pancreatic carcinoma was considered the likely tumor type based on necropsy findings. |
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Definition
Blood from a cat with a presumptive diagnosis of chronic myeloid leukemia (CML) exhibiting marked neutrophilia with a prominent left shift. A bone marrow biopsy was not done to confirm the diagnosis. Rare myeloblasts (top left) were seen in the blood film. |
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Definition
Blood from a cat with erythroleukemia (AML-M6). The two largest cells with pale-blue cytoplasm are myeloblasts. The smaller round cells are all erythroid precursors. |
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Definition
Type II myeloblast (left) and a hypersegmented neutrophil (right) in blood from a dog with myeloblastic leukemia (AML-M2) |
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Definition
Blood from a dog with acute myelomonocytic leukemia (AML-M4). A mixture of neutrophils, monocytes, and precursors of both cell types are present. |
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Definition
Blood from a cat with acute unclassified leukemia (AUL). Two unclassified neoplastic cells are presentBlood from a cat with acute unclassified leukemia (AUL). Two unclassified neoplastic cells are present |
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Definition
Blood from a cat with erythroleukemia (AML-M6Er). A neutrophil and two rubriblasts with basophilic cytoplasm are present |
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Definition
Blood from a dog with megakaryoblastic leukemia (AML-M7). Four neoplastic megakaryoblasts with prominent cytoplasmic vacuoles are present. |
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Definition
Blood from a dog with acute monocytic leukemia (AML-M5). All cells present, except a neutrophil (bottom left) are monocyte precursors or mature monocytes. |
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