Term
| when JAK activates STAT, what happens to STAT? |
|
Definition
| it is released when phosphorylated, they bind together, enter the cell, and begin transcription. |
|
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Term
|
Definition
| it blocks JAK activation of STAT |
|
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Term
|
Definition
|
|
Term
| what is the action of SOCS1? |
|
Definition
| bind to JAK and prevent activation |
|
|
Term
| what are receptor serine kinase ligands? |
|
Definition
| homodimeric peptide ligands held together by cysteine disulfide bonds |
|
|
Term
| How is TGF beta signaling occuring? |
|
Definition
|
|
Term
| what does TGF beta signaling activate? |
|
Definition
| members of the SMAD family |
|
|
Term
| how is the SMAD protein activated? |
|
Definition
| type 2 activates type 1, which then phosphorylates the SMAD protein |
|
|
Term
| what binds in conjunction with SMAD to activate transcription in the nucleus |
|
Definition
|
|
Term
| what activates SMAD 2 and 3? |
|
Definition
| TGFbeta/Activin/Nodal signaling |
|
|
Term
| what activates SMAD 1, 5, and 8 |
|
Definition
|
|
Term
| what do all SMAD ligands require? |
|
Definition
| R-Smad interaction with the Common mediator Smad 4 |
|
|
Term
| R-Smads are the only to contain this |
|
Definition
| ssxs phosphorylation motif |
|
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Term
|
Definition
|
|
Term
| what is the function of MH1 and 2? |
|
Definition
1-DNA binding
2-protein-protein interactions |
|
|
Term
| middle white linker is the site of what |
|
Definition
|
|
Term
| what is the function of the BAMBI |
|
Definition
| binding to type 2 receptor, preventing activation of R-SMAD |
|
|
Term
| binding of hedgehog does what? |
|
Definition
| inhibits patched, leading to activation of Smoothened and subsequent activation of Gli/Ci |
|
|
Term
| what does wnt binding do? |
|
Definition
| leads to stabilization of Beta catenin and downstream signaling. |
|
|
Term
| what is the action of TNF (IL-1) on NFkB |
|
Definition
|
|
Term
| explain delta notch signaling |
|
Definition
it directs cell-cell interaction during development.
proteolytic cleavage of the notch goes into the nucleus and activates transcription. |
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