Term
Cyp2d6 drugs affected(2 class) |
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Definition
Antidepressants, Anti-psychotics |
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Term
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Definition
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Definition
Warfarin, NSAIDs, Phenytoin, Tolbutamide |
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Definition
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Term
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Definition
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Term
Aldehyde Dehydrogenase impairment |
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Definition
Causes facial flushing with alcohol |
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Term
Pseudocholinesterase(Butyrylcholinesterase)impairment |
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Definition
Results in prolonged muscle relaxant response to succinylcholine |
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Term
N-acetyltransferase impairment |
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Definition
Associated with higher risk of neurotoxicity in isoniazid |
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Term
Thiopurine S-methyltransferase |
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Definition
Higher risk of hematopoietic toxicity for azathiopurine & 6-mercaptopurine |
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Term
UDP-glucuronosyl-transferase lower expression |
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Definition
Higher risk of toxicity for irinotecan |
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Term
Glutathione S-transferase |
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Definition
Higher risk of toxicity with various anti-cancer drugs |
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Term
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Definition
Affects toxicity of anti-cancer drugs, digoxin, and other drugs |
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Term
Organic Anion transporters |
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Definition
Affects statins and methotrexate |
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Term
Organic cation transporters |
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Definition
Therapeutic effect of metformin |
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Term
Vitamin K epoxide reductase |
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Definition
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Term
Thymidylate synthase and methylenetetrahydrofolate reductase |
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Definition
Affect methotrexate adverse effects |
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Term
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Definition
Gq, increases intracellular calcium, predominate in CNS |
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Term
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Definition
Gi opening of K+ channels and reduction in cAMP and predominates in myocardium |
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Term
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Definition
Gq, increases intracellular calcium, subtype predominates in exocrine glands, vascular endothelium, & smooth muscle |
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Term
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Definition
Gi opening of K+ channels and reduction in cAMP and predominates in CNS |
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Term
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Definition
Gq, increases intracellular calcium, predominates in vascular endothelium of cerebral vessels |
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Term
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Definition
Gq, increases intracellular calcium, predominates in smooth muscle-including most vascular smooth muscle |
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Term
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Definition
Gi opening of K+ channels and reduction in cAMP, inhibitory autoreceptor on pre-synaptic nerve terminals, predominates on platelets, adipocytes, and smooth muscle |
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Term
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Definition
through Gs AND elevation of cAMP |
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Term
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Definition
predominates on heart and renal tubules |
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Term
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Definition
predominates in lung and various types of smooth muscle |
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Term
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Definition
predominates in adipocytes |
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Term
Sympathetic mediated by B1(heart) |
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Definition
increased heart rate and force of contraction |
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Term
Sympathetic mediated by B1 and m3(blood) |
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Definition
increased blood flow to skeletal muscle |
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Term
Sympathetic mediated by a1(skin) |
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Definition
decreased blood flow to skin and viscera |
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Term
Sympathetic mediated by B2(lung) |
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Definition
relaxation of bronchiolar smooth muscle |
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Term
Sympathetic mediated by a1(eyes) |
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Definition
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Term
Sympathetic mediated by B2 and a1(sugar) |
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Definition
Increased gluconeogenesis and glycogenolysis in liver |
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Term
Sympathetic mediated by B3(fat) |
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Definition
increased lipolysis in fat cells |
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Term
Sympathetic mediated by B1(kidney) |
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Definition
increased renin release from kidney |
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Term
Parasympathetic mediated by m2(heart) |
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Definition
reduced heart rate, minimal effect on force of contraction |
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Term
Parasympathetic mediated by m3(lung) |
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Definition
contraction of bronchiolar smooth muscle |
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Term
Parasympathetic mediated by m3(eyes) |
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Definition
constriction of pupils in eyes and accomadation |
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Term
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Definition
short-acting and non-selective direct acting cholinergic agonist |
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Term
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Definition
short-acting and selective direct acting cholinergic agonist |
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Term
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Definition
long acting, non-selective direct acting cholinergic agonist, primarily for glaucoma |
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Term
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Definition
long acting, selective direct acting cholinergic agonist |
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Term
Direct acting Cholinergic agonist effects |
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Definition
Vasodilation, increase in heart rate, eye contraction,stimulate secretion, relax sphinter |
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Term
Indirect acting cholinergic agonist effects |
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Definition
Vasodilation, decrease in heart rate, eye contraction,stimulate secretion, relax sphinter |
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Term
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Definition
short acting indirect acting cholinergic agonists |
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Term
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Definition
long acting indirect acting cholinergic agonists |
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Term
Cholinergic antagonists effect |
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Definition
Inhibit secretion, relax muscles and contract sphincter, slight tachycardia |
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Term
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Definition
primarily used as nasal decon, vasoconstriction, increases systolic and diastolic BP, decreases HR |
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Term
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Definition
primarily use in OH vasoconstriction, increases systolic and diastolic BP, decreases HR |
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Term
a1 adrenoreceptor agonist |
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Definition
vasoconstriction, increases systolic and diastolic BP, decreases HR |
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Term
a2 adrenoreceptor agonist |
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Definition
suppresion of sympathetic tone, reduction in blood pressure |
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Term
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Definition
a2 adrenoreceptor agonist, primary therapeutic use in hypertension |
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Term
B1 adrenoreceptor agonist |
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Definition
increase inotropic and chronotropic effect on heart, increased cardiac output |
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Term
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Definition
B1 adrenoreceptor agonist, primary therapeutic use in acute heart failure |
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Term
B2 adrenoreceptor agonist |
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Definition
relaxation of bronchial smooth muscle, vasodilation and mild increase in heart rate and force of contaction |
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Term
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Definition
B2 adrenoreceptor agonist, primary use in asthma and COPD |
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Term
a1 adrenoreceptor antagonist |
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Definition
vasodilation, decreases venous tone, decreases arterial pressure-primarily affects diastolic pressure, relaxes smooth muscles in prostrate, |
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Term
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Definition
a1 adrenoreceptor antagonist, primary therapy to prevent urinary retention with hyperplasia of prostate |
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Term
B1 adrenoreceptor antagonist |
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Definition
negative I and C effect(decreases cardiac output), acute effect- increases peripheral resistance, chronic effect is decrease peripheral resistane, leads to decreased BP, suppreses renin release, also reduces intraocular pressue affecting glaucoma |
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Term
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Definition
B1 adrenoreceptor antagonist, affects both B receptors so problematic in asthma patients |
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Term
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Definition
B1 adrenoreceptor antagonist,more selective than propranolol |
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