Term
| What is the difference between filamentous molds and yeats? |
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Definition
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Term
| What are the three clinical circumstances in which plasma level monitoring of antifungal agents can be indicated? |
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Definition
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Term
| What is the difference between "aquired" & "intrinsic" resistance to fluconazole? |
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Definition
Intrinsic resistance: resistance recorded prior to drug exposure in vivo or in vitro
Acquired resistance: resistance that develops on exposure to antifungal
Resistance mechanism: increased drug efflux, upregulation of ERG11, alteration in sterol composition, decreased azole binding due to mutation in ERG11 |
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Term
| What are fine species of Candida that are commonly encountered in the clinical setting? |
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Definition
C. albicans (most common for nosocomial fungal blood stream infection)
C. glabrata
Aspergillus
Trichosporon
Fusarium |
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Term
| What are treatment options for hematogenously disseminated candidiasis caused by Candida? |
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Definition
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Term
| What are treatment options for the treatment of invasive aspergillosis? |
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Definition
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Term
| What are common mechanisms of drug interactions with azole antifungal? |
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Definition
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Term
| What are common ADE of various formulations of amphotericin B? |
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Definition
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