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Intro. to Pathophysiology
Intro., Homeostasis, Adaptation
159
Physiology
Undergraduate 4
06/06/2010

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Term
What are the 4 rules of the human body?
Definition
1. Variable
2. Lazy
3. Conservative
4. Redundant
Term
Variable means that...
Definition
...people are not exactly the same.
Term
Lazy means that...
Definition
...the body doesn't want to work harder than it needs; it does the least amount of work possible; it's efficient.
Term
Conservative means that...
Definition
...(in response to stimuli) it is careful with regards to responses and reactions.
Term
Redundant means that...
Definition
...it is repetitive; there's more than one way to do a certain task; there are many mechanisms for a single function.
Term
List the 11 body systems.
Definition
1. Cardiovascular
2. Endocrine
3. Gastrointestinal
4. Immune
5. Integumentary
6. Muscular
7. Nervous
8. Renal
9. Reproductive
10. Respiratory
11. Skeletal
Term
What are 3 fxns. of the cardiovascular system?
Definition
1. Maintenance of fluid balance
2. Thermoregulation
3. Transportation
Term
What are 3 structures of the cardiovascular system?
Definition
1. Heart
2. Blood vessels
3. Blood
Term
What are 4 examples of blood vessles?
Definition
1. Arteries
2. Veins
3. Capillaries
4. Lymph vessels
Term
With regards to the cardiovascular system, what do lymph vessels do?
Definition
Return interstitial fluid to the capillaries.
Term
T/F You typically tend to gain fluid across the capillaries.
Definition
False; you lose fluid
Term
What are 3 disorders of the cardiovascular system?
Definition
1. Stenosis
2. Congestive heart failure
3. Heart attack
Term
The endocrine system includes anything that makes ____________.
Definition
hormones
Term
What are 2 fxns. of the endocrine system?
Definition
1. Secrete hormones directly into bloodstream
2. Long-term homeostasis
Term
What are 3 structures of the endocrine system?
Definition
1. Glands
2. Heart
3. Stomach
Term
What are 3 disorders of the endocrine system?
Definition
1. Hypothyroidism
2. Dwarfism
3. Diabetes
Term
What are 3 fxns. of the gastrointestinal system?
Definition
1. Break-down food for absorption
2. Re-absoprtion of water
3. Waste excretion
Term
What re 2 structures of the gastrointestinal system?
Definition
1. Stomach
2. Liver
3. Pancreas
Term
What are the 2 main segregations of the gastrointestinal system?
Definition
1. GI tract
2. Accesory organs
Term
What are 3 disorders of the gastrointestinal system?
Definition
1. Gastric ulcers
2. Malabsorption
3. IBS (irritable bowel syndrome)
Term
What is the function of the immune system?
Definition
Protection
Term
What are 3 structures of the immune system?
Definition
1. Lymph nodes
2. Lymph vessels
3. Thymus
Term
What are 3 disorcers of the immune system?
Definition
1. Auto-immune
2. Allergies
3. HIV/AIDS
Term
With regards to the immune system, what is the purpose of the lymph vessels?
Definition
Fluid balance
Term
What are 3 fxns. of the integumentary system?
Definition
1. Protection
2. Thermoregulation
3. Vitamin D production
Term
What are 3 structures of the integumentary system?
Definition
1. Skin
2. Skin glands
3. Nails
Term
What are 3 disorders of the integumentary system?
Definition
1. Acne
2. Chicken pox
3. Dermatitis
Term
What 2 things do skin glands produce?
Definition
1. Sweat
2. Oil
Term
What are 3 fxns. of the muscular (skeletal muscular) system?
Definition
1. Movement
2. Stability
3. Thermoregulation
Term
What are 3 structures of the skeletal (skeletal muscular) system?
Definition
1. Muscles
2. Muscle-associated connective tissue
3. Tendons
Term
What are 3 disorders of the muscular (skeletal muscular) system?
Definition
1. Tetanus
2. Botulism
3. Muscular dystrophy
Term
What are 3 fxns. of the nervous system?
Definition
1. Input
2. Integration
3. Output
Term
What are 3 structures of the nervous system?
Definition
1. Receptors
2. Nerves
3. CNS (brain, spinal cord)
Term
What re 3 disorders of the nervous system?
Definition
1. Alzheimer's
2. Parkinson's
3. Cerebral palsy
Term
What are 3 fxns. of the renal system?
Definition
1. Blood filtration
2. Long-term pH balance
3. Regulation
Term
What are 3 things that the renal system regulates?
Definition
1. Plasma volume
2. Plasma ions
3. Electolytes
Term
The renal system produces ________, which increases RBC production).
Definition
EPO (erythropoetin)
Term
The renal system activates what vitamin?
Definition
D
Term
What are 3 structure of the renal system?
Definition
1. Kidneys
2. Bladder
3. Urethra
Term
What are 3 disorders of the renal system?
Definition
1. Kidney stones
2. Renal failure
3. Urinary tract infection
Term
Which is the only system that doesn't have anything to do with homeostasis?
Definition
Reproductive
Term
Which is the one system we can live without?
Definition
Reproductive
Term
What are 3 fxns. of the reproductive system?
Definition
1. Union of gametes
2. Gamete storage
3. Hormone production
Term
What are 3 structures of the reproductive system?
Definition
1. Penis
2. Vagina
3. Uterus
Term
What are 3 disorders of the reproductive system?
Definition
1. Prostate cancer
2. PCOS (polycystic ovarian syndrome)
3. Endometriosis
Term
What are 3 fxns. of the repiratory system?
Definition
1. Transportation
2. Short-term pH balance
3. Protection
Term
What are 3 structure of the respiratory system?
Definition
1. Nose
2. Lungs
3. Diaphragm
Term
What are 3 fxns. of the skeletal system?
Definition
1. Support
2. Mineral storage
3. Protection
Term
What are 3 structures of the skeletal system?
Definition
1. Bones
2. Ligaments
3. Joints
Term
What are 3 disorders of the skeletal system?
Definition
1. Arthritis
2. Bone trauma
3. Osteoporosis
Term
List the body's 2 control systems.
Definition
1. Nervous
2. Endocrine
Term
What 3 things define the body's control systems?
Definition
1. Masters of their domains
2. Cannot live without them
3. Maintain homeostasis
Term
Describe the distinctions b/w the nervous and endocrine systems (as control systems).
Definition
Nervous - very fast, immediate control of things; hard-wired (w/ exception of synapses); very protective; short-term homeostasis; turns-on sympathetic/automatic responses
Endocrine - slow; hormone-medated; long-term homeostasis
Term
Define dynamic homeostasis.
Definition
Maintaining flux around a set-point, where not everything requires a response
Term
Regarding dynamic homeostasis, within the thresholds, the body (does/does not) need to respond; anything that falls _________ the thresholds requires a response.
Definition
Doesn't; above or below
Term
Dynamic homeostasis is maintained only in one place or internal environment. Where is that place?
Definition
Extracellular fluid
Term
Extracellular fluid is found in what 2 places?
Definition
1. Plasma
2. Interstitial fluid
Term
What is the exception to the rule that, "if it can cross the wall, it will be in equal concentration both inside and out"?
Definition
Proteins
Term
What is the exception to the rule that, "if it can cross the wall, it will be in equal concentration both inside and out"?
Definition
Proteins
Term
What are the 2 types of feedback.
Definition
1. Negative
2. Positive
Term
Which form of feedback is most common?
Definition
Negative
Term
Negative feedback includes anything with a ________; it's a ________ system (where the response occurs in the __________ direction of the change).
Definition
Set-point; return; opposite
Term
What are 3 examples of negative feedback?
Definition
1. Blood pressure
2. Blood volume
3. Temperature
Term
Positive feedback is a _______ system; these parameters do not have a _________/__________ where they need to be maintained; they runaway in the _________ direction as the initial change.
Definition
Runaway; set-point; baseline; same
Term
Correct an increase in temperature.
Definition
Peripheral vasodilation, sweating, increased vasopressin (thirst), decreased T3T4 (metabolic rate), increased insulin (energy storage)
Term
Correct a decrease of temperature.
Definition
Shivering, peripheral vasoconstriction, increased T3T4, increased epinephrine/cortisol/glucagon (fuel mobilization)
Term
A feedback loop includes what 5 things?
Definition
1. Sensor
2. Input
3. Integration
4. Output
5. Effector responses
Term
Define sensor.
Definition
Any kind of receptor that's picking up information
Term
List 6 receptors.
Definition
1. Thermoreceptor
2. Chemoreceptor
3. Baroreceptor
4. Photopreceptor
5. Mechanoreceptor
6. Osmoreceptor
Term
What are the 2 forms of receptors with relation to location in the body?
Definition
1. Cutaneous
2. Core
Term
What are the 2 forms of receptors with relation to location in the body?
Definition
1. Cutaneous
2. Core
Term
What are the 2 forms of receptors with relation to location in the body?
Definition
1. Cutaneous
2. Core
Term
Thermoreceptors are driven by (core/cutaneous) receptors.
Definition
Core
Term
Plasma calcium ahs decreased. Fill in the feedback loop.
Definition
Sensor - chemoreceptors (core and cutaneous)
Input - afferent neuron
Integration - CNS
Output - efferent neuron
Effector response - increased parathyroid hormone, which increases plasma calcium
Term
What does T3T4 do?
Definition
Increases metabolic rate
Term
What doe epinephrine, glucagon, and corisol do?
Definition
Mobilize fuel
Term
What does insulin do?
Definition
Stores fuel
Term
What does parathyroid do?
Definition
Increases plasma calcium
Term
What does calcitonin do?
Definition
Decreases plasma calcium
Term
Define gain.
Definition
A way of quantifying how good the body is at doing something
Term
Gain = _________/_________
Definition
Compensation; error
Term
Regarding gain, define compensation.
Definition
How much change was buffered or compensated for
Term
Regarding gain, define error.
Definition
How much we change from baseline
Term
Regarding gain, >5 is ______, while <5 is ________.
Definition
Good; bad
Term
Gain gets (better/worse) over time.
Definition
Better
Term
Regarding gain, a large positive is ______ (________/_______).
Definition
Good; big c; small e
Term
Regarding gain, a small positive is _______ (______/_______).
Definition
Bad; small c; big e
Term
Regarding gain, a large negative is _____ (______/______).
Definition
Good; big c; small e
Term
Regarding gain, a small negative is _____ (_____/_____).
Definition
Bad; large c; large e
Term
Regarding gain, any negative, whether small or large, means what?
Definition
Overcompensation
Term
List the 4 tissue types.
Definition
1. Connective
2. Epithelial
3. Muscle
4. Nervous
Term
What are 11 fxns. of connective tissue?
Definition
1. Connect
2. Structural support
3. Cushion
4. Transport
5. Protection
6. Hematopoesis
7. Mineral storage
8. Fat/nutrient storage
9. Outward structures
10. Embryonic skeleton
11. Thermoregulation
Term
What are the 4 types of connective tissue?
Definition
1. Blood
2. Bone
3. Cartilage
4. Connective tissue proper
Term
What are the 2 forms of connective tissue proper?
Definition
1. Loose connecive tissue
2. Dense connective tissue
Term
Give an example of loose connective tissue.
Definition
Adipose
Term
Give 3 examples of dense connective tissue.
Definition
1. Tendons
2. Ligaments
3. Organ capsules
Term
What are the 4 characteristics of connective tissue?
Definition
1. Few cells
2. Abundant matrix
3. Varied vascularity
4. Varied innervation
Term
List the 4 connective tissue cell types.
Definition
1. Osteocyte (bone)
2. Erythrocyte (blood)
3. Chondrocyte (cartilage)
4. Fibrocyte (CT proper)
Term
Define hematopoesis.
Definition
Production of white/red blood cells and platelets.
Term
What are 8 fxns. of epithelial tissue.
Definition
1. Protection
2. Secretion
3. Filtration
4. Reabsorption
5. Absorption
6. Lubrication
7. Barrier
8. Conduits
Term
Matrices are made of what 2 things?
Definition
1. Fiber
2. Protein
Term
What are 5 characteristics of epithelial tissue?
Definition
1. Densely packed cells
2. Very little matrix
3. Avascular
4. Rapidly regenerative
5. All innervated
Term
Epithelial tissue is innervated by __________ tissue, which includes _______ and ________ messages.
Definition
Autonomic; sympathetic; parashympathetic
Term
The most common cell to be stratified is _________.
Definition
Squamous
Term
By what 2 things is epithelial tissue classified?
Definition
1. Shape of cell
2. # of layers of cells
Term
List the 3 epithelial tissue cell shapes.
Definition
1. Squamous
2. Cuboidal
3. Columnar
Term
Describe a squamous cell.
Definition
Flat and disk-shaped
Term
Describe a cuboidal cell.
Definition
Square with a centrally located round nucleus
Term
Describe a columnar cell.
Definition
Rectangular with elongated nucleus at the bottom
Term
Regarding epithelial tissue, classification by # of layers of cells is either ________ or _________.
Definition
Simple; stratified
Term
What are 3 functions of simple squamous cells?
Definition
1. Diffusion
2. Filtration
3. Exchange
Term
List 3 locations where simple squamous cells can be found.
Definition
1. Capillaries
2. Alveoli
3. Glomerulous
Term
List 3 fxns. of simple cuboidal cells.
Definition
1. Secretion
2. Absorption
3. Reabsorption
Term
List 3 places where simple cuboidal cells can be found.
Definition
1. Kidney tubules
2. Small intestine
3. Thyroid gland
Term
List 2 functions of simple columnar cells.
Definition
1. Secretion
2. Absorption
Term
List 3 places where simpel columnar cells can be found.
Definition
1. Small intestine
2. Large intestine
3. Gallbladder
Term
What is the main function of muscle tissue?
Definition
Generate force or tension
Term
What are the 3 types of muscle tissue?
Definition
1. Skeletal
2. Cardiac
3. Smooth
Term
What are 2 functions of skeletal muscle tissue?
Definition
1. Movement
2. Locomotion
Term
What are 7 characteristics of skeletal muscle tissue?
Definition
1. Striated
2. Multinucleated
3. Cylindrical
4. Long
5. Poor regeneration
6. Neurogenic
7. Innervated by somatic motor neurons
Term
Define neurogenic.
Definition
Action is directed by neurons
Term
What is the main function of cardiac muscle tissue?
Definition
Generate tension to move blood; pumping
Term
What are 7 characteristic of cardiac muscle tissue?
Definition
1. Branched
2. Uninucleate
3. Striated
4. Poor regeneration
5. Myogenic
6. Innervated by autonomic neurons
7. Connected by intercollated disks
Term
Define myogenic.
Definition
Self-generated activity
Term
What are 2 main functions of smooth muscle tissue?
Definition
1. Controlling flow rate
2. Moving things forward
Term
List 6 characteristics of smooth muscle tissue.
Definition
1. Not striated
2. Uninucleate (centrally located)
3. Spindle-shaped
4. Neurogenic or myogenic
5. Innervated by autonomic neurons
6. Regenerative
Term
List 2 types of nervous tissue.
Definition
1. Neurons
2. Glial cells
Term
List 2 functions of neurons.
Definition
1. Collect info.
2. Make and release neurotransmitters
Term
Neurons (are/are not) regenerative.
Definition
Are not
Term
Glial cells (are/are not) regenerative.
Definition
Are (very)
Term
Brain cancers and tumors almost always involve ______ cells.
Definition
Glial
Term
Give 3 examples of things that harm cells.
Definition
1. Age
2. Infection
3. Abrasion
Term
List the 3 cell and tissue responses to injury or stressors.
Definition
1. Recovery
2. Death
3. Adaptation
Term
List the 3 cell and tissue responses to injury or stressors.
Definition
1. Recovery
2. Death
3. Adaptation
Term
List the 2 types of cell/tissue death.
Definition
1. Apoptosis
2. Necrosis
Term
Define apoptosis.
Definition
Programmed/controlled cell death
Term
Defne necrosis.
Definition
Unplanned/unregulated cell death
Term
T/F Necrosis is sometimes beneficial.
Definition
True
Term
What is the most common cell/tussue response to injury/stress?
Definition
Adaptation
Term
List the 5 types of cell/tissue adaptation to injury/stress.
Definition
1. Atrophy
2. Hypertrophy
3. Hyperplasia
4. Metaplasia
5. Dysplasia
Term
Define atrophy
Definition
Decrease in size
Term
Which 2 adaptations do not entail physiological and pathological changes?
Definition
1. Metaplasia
2. Dysplasia
Term
Describe the physiological aspect of atrophy.
Definition
No stimulus to maintain size; nothing wrong; disuse
Term
Describe the pathological aspect of atrophy.
Definition
Something causes cell/tissue to get smaller
Term
Give 3 examples of Physiological atrophy.
Definition
1. Laziness
2. Bed rest
3. Cast
Term
Give 3 examples of pathological atrophy.
Definition
1. Denervation
2. Disease
3. Muscular dystrophy
Term
Define hypertrophy.
Definition
Increase in size
Term
Give 3 examples of physiological hypertrophy.
Definition
1. Adding muscle bulk
2. Excercise
3. Weight training
Term
Give 2 examples of pahological hypertrophy.
Definition
1. Cardiac/ventricular hypertrophy
2. Chronically pumping against high resistance
Term
Define hyperplasia.
Definition
Increasing by division/addition
Term
In what 2 tissue types does hyperplasia typically occur?
Definition
1. Epithelial
2. Smooth muscle
Term
Give 3 examples of physiological hyperplasia.
Definition
1. EPO (blood doping)
2. Breast size in pregnancy
3. Placental formation
Term
Give and example of pathological hyperplasia.
Definition
Prostatic hyperplasia
Term
T/F Prastatic hyperplasia is almost always malignant.
Definition
False; benign
Term
Define metaplasia.
Definition
Replacing one cell type with another
Term
Give 2 examples of metaplasia.
Definition
1. Scar tissue
2. Smokers' airways
Term
Define dysplasia.
Definition
A change in size, structure, border, shape of existing cells
Term
What is the only cell/tissue adaptation that increases one's risk of malignancy?
Definition
Dysplasia
Term
What are the 2 most common stressors?
Definition
1. Pregnancy
2. Endurance exercise
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