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introdution to immune system
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39
Biology
Undergraduate 3
05/01/2009

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Term
The immune system
Definition
a complex defense system that protects us from foreign invaders such as: pathogenic micro-organisms, viruses, abnormal cells (cancer) or tissues form another individual.
Term
what does the immune system use as markers for "self" vs. "non-self"?
Definition
MHC
Term
define:antigen
Definition
a substance that is marked as non-self and is capable of triggering an immune response
Term
what is another name for epitope?
Definition
antigenic determinant
Term
define: epitope
Definition
the distinctive markers on an antigen that triggers an immune response
Term
layman epitope definition
Definition
small part of the antigen that the immune system recognizes as being foreign
Term
what is the source of all blood cells?
Definition
the bone marrow
Term
thymus
Definition
small organ behind the breast, where the t cells mature
Term
thymus
Definition
small organ behind the breast, where the t cells mature
Term
spleen
Definition
has compartments where the immune cells gather to confront antigens
Term
where can the immune cells confront the antigens?
Definition
the spleen, the lymph nodes, and in patches lining the digestive tract and the airways
Term
what is the function of lymphatic vessels
Definition
connect lymph nodes to each other and to other immune system organs
Term
what system do the immune cells go thru to patrol against antigens?
Definition
the lymphatic system
Term
another description of lymphatic vessels
Definition
a series of vessels where blood system exchange materials with lymphatic system
Term
which cells produce antibodies?
Definition
the b-cells
Term
innate immunity
Definition
general rather than specific immune response
Term
hematopoietic stem cells
Definition
an adult stem cell that is capable of differentiating and developing into many types of immune cells. they do not have function in of themselves but can instead differentiate
Term
what do hematopoietic stem cells first develop into?
Definition
multipotent cells
Term
what two precursor cells does the multipotent cell give rise to?
Definition
the myeloid progenitor and the lymphoid progenitor
Term
what progenitor cell gives rise to the innate immune system?
Definition
the myeloid progenitor
Term
what does the lymphoid progenitor cell give rise to?
Definition
the acquired immune system. which recognizes the specific pathogens and triggers specific responses
Term
examples of cells the myeloid progenitor cell gives rise to
Definition
monocytes, neutrophils, eosinophils, and basophils, erythrocytes
Term
examples of cells from the lymphoid progenitor cell
Definition
b-cells,t-cells, APC, NK cells, dendritc cell
Term
monocytes
Definition
develop into macrophages
Term
macrophages
Definition
swallow foreign invaders
Term
neutrophils
Definition
engulf bacteria
Term
eosinophils
Definition
attack parasites
Term
basophils
Definition
release allergy related molecules, histamines
Term
b lymphocyte
Definition
important in the production of antibodies
Term
t-lymphcyte
Definition
attack foreign or altered self cells wwhich have been infltrated with antigen, they also help b cells develop
Term
dendritic cell(Antigen Presenting Cell)
Definition
engulf micro-organisms and present it on surface, so they can be recognized by b-cells to produce antibodies
Term
Natural Killer cell (nk)
Definition
engulf self altered cells...via virus for example
Term
major barriers in innate immunity
Definition
skin, mucous membranes, skin secretions, saliva, tears, nasal secretions, perspiration, cilia in lungs
Term
the funtion of skin in innate immunity
Definition
pathogens can't get in
Term
the function of mucous membranes
Definition
contain sticky stuff to trap pathogens and microorganisms
Term
skin secretions
Definition
may be acidic and kill pathoges or prevent them form getting in, may lyse them even
Term
function of saliva, tears, nasal secretions, perspiration
Definition
make lysosomes..and lyse cells
Term
function of cilia in the lungs of innate immunity
Definition
sweep microorganisms out of the air ways
Term
what are the four antimicrobial agents of the innate immunity system
Definition
interferon, interleukins, lactoferrin, transferrin, complement
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