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Introduction
Preventive THerapeutics
58
Pharmacology
Undergraduate 1
09/17/2012

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Term
Primary prevention
Definition
remove or reduce disease risk factors; ex: immunization, giving up or not starting smoking and aspirin to prevent first heart attack
Term
secondary prevention
Definition
promote early detection of disease or precursor states; Ex: PAP or aspirin after first stroke to prevent another
Term
tertiary prevention
Definition
aimed at limiting the impact of established disease; ex: mastectomy and radiation therapy to remove breast cancer
Term
level 1 preventive services
Definition
providers and care systems MUST assess the need for and recommend these services to every patient. these have the highest values and are worhty of attention at every opportunity
Term
level 2 preventive services
Definition
providers and care systems SHOULD assess the need for and recommend these services to every patient. These have demonstrated value, although less than level 1 services, and should be provided whenever possible.
Term
level 3 preventive services
Definition
providers and care systems COULD recommend these services to patients, but only after careful consideration of costs and benefits. Evidence for the services is incomplete or equivocal or may have potential for harm. ...left to the judgment of the individual medical group, clinician and their patients
Term
level 4 preventive services
Definition
these services are not supported by evidence and should not be recommended. insufficient evidence on effectiveness, clearer evidence of lack of effectiveness or potential for harm without benefit
Term
Ex of Level 1 services
Definition
alcohol abuse screening and counseling, aspirin chemoprophylaxis counseling, cervical cancer screening, breast cancer screening, chlamydia screening, colorectal cancer screening, hypertension screening, influenza immunization, lipid screening, pneumococcal immunization, tobacco use screening and intervention
Term
ex of level II services
Definition
AAA screening, depression screening, folic acid chemoprophylaxis counseling, hearing screening, Hep B immunization, Zoster immunization, HPV immunization, IPV immunization, MMR immunization, Obesity screening, Osteoporosis screening, Tetanus-diptheeria immunization, varicella immunization and vision screening
Term
alcohol screening
Definition
19- 65 and older= identify risky or hazardous drinking and criteria for dependence and provide brief intervention
Term
aspirin chemoprophylaxis counseling
Definition
men 45-79 for MI and women 55-79 for stroke
Term
breast cancer screening
Definition
mammogram every one to two years for women 50-75
Term
cervical cancer screening
Definition
<21= no screeening
21-29= every two years
30-39= every three years
40-64= every three years after three consecutive normal Pap tests
>65= stop if no abnormal pap in 10 years
Term
chlamydia screening
Definition
all sexually active women 25 and younger and older women with new or multiple partners
Term
colorectal cancer screening
Definition
>50 or >45 for AA and AI/AN
76-85= no screening unless significant consideractions
>86= no screening
Term
hypertension screening
Definition
BP every 2 years if less than 120/80; every year it 120-139/80-89
Term
influenza immunization
Definition
annually during flu season for all individuals
Term
lipid screening
Definition
men >34= every 5 years fasting fractionated lipid screening
Men >34 and women > 44= fasting fractionated lipid screening
Term
pneumococcal immunization
Definition
19-64- high risk groups once and reimmunize those at risk of losing immunity after 5 years
>65= if not previously immunized or if first received more than 5 years ago and before age 64, or an immunocompromised pt.
Term
tobacco use screening
Definition
>19= establish tobacco use status for all patients; provide brief intervention
Term
AAA screening
Definition
men 65-75 who have ever smoked
Term
depression screening
Definition
>19= routine screening; treatment and follow-up
Term
folic acid chemoprophylaxis counseling
Definition
19-64= women of reproductive age to consume 400-800 mg per day
Term
hearing screening
Definition
>40= screening followed by counseling on the availability of hearing aid devices and making referrals for older adults
Term
Hep B immunization
Definition
routine immunization for young adults less than 40
Term
Herpes zoster/shingles immunization
Definition
immunize at 60 and older in pts with no contraindications
Term
HPV immunization
Definition
for all 11-12 year old females and catch up for F age 12-26
Term
IPV immunization
Definition
adults not previourly immunized against polio
Term
MMR immunization
Definition
born during or after 9157 should have one dose; a second dose in special circumstances
Term
obesity screening
Definition
record height, weight and calculate body mass index at least annually
Term
osteoporosis screening
Definition
<65= post menopausal and determined to have a significantly increased fracture risk
>65= screened
Term
tetanus-diptheria immunization
Definition
one-time dose for Tdap who have not received previously or for whom vaccine status is unknown
Term
varicella immunization
Definition
all adults without evidence of immunity; one dose followed by a second dose at least 28 days after; catch-up dose to all children, adolescents and adults who received only one dose previously
Term
vision screening
Definition
>65= objective vision testing
Term
passive immunization
Definition
transfer of immunity as Ab which were produced by an immune animal or human to a non-immune recipient; temporary; lasts weeks to months; ex: transplancental transfer of maternal Ab
Term
homologous pooled human Ab
Definition
immune globulin; combining IgG Ab fraction from thousands of adult donors; primarily for postesposure prophylaxis for Hep A and measles
Term
Homologous human hyperimmune globulins
Definition
Ab products that contain high titers of specific Ab; dontated of humans with high levels of the Ab (other Ab in lesser quantities); against Hep B, rabies, Tetanus and varicella
Term
heterologous hyperimmune serum
Definition
aka antitoxin; produced in animals (horses); can result in serum sickness; Ab against only one antigen; botulism and diphteria
Term
monoclonal Ab
Definition
single clone of B cells; contain Ab t only one Ag; diagnosis of certain cancers, treatment of cancer, prevention of transplant rejection, and treatmet of AI and infectious disease; ex: palivizumab is a monoconal Ab for RSV
Term
active immunization
Definition
production of Ab or T cells by the patient's body after exposure to an infectious agent; made from the microorganism or its products to develop protective immunity; takes days or weeks; long lasting because of memory B and T cells
Term
live attenuated vaccine
Definition
altered or weakened organism that causes disease, induces an immunological response; typically lifelong immunity with a single dose or series; may cause disease;
Term
pts you dont give live attenuated vaccines to
Definition
HIV-infection, chronic steroids, chemotherapy, transplant patients on immunosuppressive drugs
Term
inactivated vaccines
Definition
composed of the whole or part of a killed virus or bacteria; incapable of replication or causing the disease; humoral immune response
Term
subunit vaccine
Definition
acellular components such as antigenic peptides, capsular polysaccharides or cell surface protein Ag; enhanced safety profiles and increased immunogenicity to stimulat both cellular and humoral immunity; booster doses required
Term
pts with subunit vaccines
Definition
immunocompromised but immune response may not be adequate to protect them from the disease
Term
ex or subunit vaccines
Definition
tetanus and diphtheria
Term
adjuvants
Definition
commonly aded to vaccines and toxoids to increase the immunogenicity of the agent; ex: diphtheria, tetanus and pertussis; common= salts or gels
Term
what products require >2 doses
Definition
inactivated vaccines, toxoids, recombinant subuit vaccines, polysaccharide conjugate vaccines and live vaccines; ex: tetanus and diphtheria
Term
what vaccines do not induce T cell memory
Definition
unconjugated polysaccharide vaccines
Term
% of recipients developing protective Ab within 14 days
Definition
90-95%
Term
% protected for varicell adn mmps
Definition
80-85%
Term
why give a second dose for MMR?
Definition
becuase a limitd proportion 5-15% fail to respond to 1 dose
Term
when should you give immunizations if not on the same day?
Definition
separated by 4 weeks to reduce the risk of a reduced immune response
Term
what happens if given a vaccine too close together or too younga an age?
Definition
can lead to a suboptimal immunse response
Term
what is the earliest you can give an immunization before the age/interval
Definition
< or = 4 days
Term
why would active immunity from a live attenuated vaccine not develop?
Definition
interference from circulating Ab to the vaccine virus
Term
webite for the VAERS
Definition
www.fda.gov/cber/vaers/vaers.htm
Term
CDC resource for common patient questions
Definition
http://www.cc.gov/vaccines/parents/index.html
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