Term
| What are the Molecular Koch Postulates? |
|
Definition
SHORT
Gene causes disease, mutation of disease lessens virulence and addition of WT gene restores it.
1) Property encoded by virulence gene should be associated with pathogenic strains
2) Inactivation of gene should lessen virulence.
3) Addition of cloned copy of WT gene to mutant should restore virulence. |
|
|
Term
| How can you target and inactivate a virulence gene using molecular techniques? |
|
Definition
| 1) transform bacteria with a plasmid containing a targeted transposon. |
|
|
Term
| What is the "infectious cycle"? |
|
Definition
1) Entry
2) Adherence/Colonization
3) Invasion
4) Evasion
5) Damage
6) Dissemination |
|
|
Term
| What is the only fungus that is an extracellular pathogen? |
|
Definition
|
|
Term
| What is the only Parasite that is an extracellular pathogen? |
|
Definition
|
|
Term
| What is the only Gram (+) bacteria that NOT an extracellular pathogen? |
|
Definition
| Listeria monocytogenes (facultative intracellular microbe) |
|
|
Term
| What are Koch's Postulates? |
|
Definition
1) organism always found in disease model but not healthy
2) organism can be isolated and grown away from animal
3) when re-inocculated, it can cause disease
4) organism can be re-isolated from animals |
|
|
Term
| What is the difference between infections and intoxications? |
|
Definition
1) Infections require pathogen to be living inside host
2) Pathogen does not need to stay viable, just need toxin (Botulism) |
|
|
Term
| Which bacteria are obligate intracellular pathogens? |
|
Definition
Mycobacterium leprae
Chlamydiae
Rickettsia spp. |
|
|
