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Introduction to Hematology
introduction to hematology
112
Veterinary Medicine
Not Applicable
08/24/2010

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Cards

Term
What is the form and structure of blood cells called?
Definition
morphology
Term
What is the function of blood and its components called?
Definition
physiology
Term
What is the disease state causing changes of the blood cell called?
Definition
pathology
Term
What are the six functions of blood?
Definition
1. support tissue metabolism
2. remove waste
3. regulate blood clotting
4. protection
5. messanging
6. homeostasis
Term
What is the pH of blood?
Definition
7.4
Term
What percentage of blood is made of water?
Definition
90%
Term
What percentage of blood is made plasma?
Definition
55%
Term
What percentage of blood is dissolved solids?
Definition
10%
Term
What percentage of blood is made of cells?
Definition
45%
Term
What cells make up the cellular portion of blood?
Definition
1. red blood cells
2. white blood cells
3. platelets
Term
An erythrocyte is also called a...?
Definition
red blood cell
Term
A leukocyte is also called a...?
Definition
white blood cell
Term
A thrombocyte is also called a...?
Definition
platelet
Term
What is whole blood?
Definition
blood that is not seperated
Term
What is plasma?
Definition
the liquid portion of uncoagulated blood
Term
What is serum?
Definition
the liquid portion of coagulated blood
Term
How do you calculate total amount of blood that can be safely drawn?
Definition
1. find the total blood volume
2. 10% of total blood volume can be drawn
Term
How do you calculate the total blood volume?
Definition
multiply the weight (kg) by 10%
Term
What is in a purple topped tube?
Definition
EDTA
Term
What is a purple topped tube used for?
Definition
CBCs
Term
What is in a blue topped tube?
Definition
sodium citrate
Term
What is a blue topped tube used for?
Definition
clotting assays
Term
What is in a green topped tube?
Definition
lithium heparin
Term
What is a green topped tube used for?
Definition
plasma chemistries
*do not use for smears it will stain blue
Term
What is in a red topped tube?
Definition
no additives
Term
What is in a gray & red topped tube?
Definition
silicon separator
Term
What is a gray & red topped tube used for?
Definition
separating serum from RBC's while centrifuged
Term
What is in a red & black topped tube?
Definition
clotting activator that cuts clotting
Term
What is in a yellow topped tube?
Definition
clotting activator that cuts clotting time in half
Term
What is a red & black topped tube used for?
Definition
separating serum
Term
What is a yellow topped tube used for?
Definition
separating serum
Term
Which two tubes are the same?
Definition
the yellow and the red & black topped tubes
Term
What is in a gray topped tube?
Definition
diatomaceous earth
Term
What is a gray topped tube used for?
Definition
an Activated Clotting Time (ACT) test
Term
What does a vacutainer tube do?
Definition
sucks the blood into the container with a vacuum
Term
What is the color of normal serum?
Definition
straw
Term
What is the color of fatty serum?
Definition
white
Term
What does white serum indicate the presence of?
Definition
fat
Term
What is the color of hemolytic serum?
Definition
pink or red
Term
What does pink or red serum indicate?
Definition
RBCs have ruptured
Term
What does amber to orange/brown serum indicate?
Definition
the presence of bilirubin (indicates liver problem)
Term
What is amber to orange/brown serum called?
Definition
icterus
Term
How long can plasma and serum be stored at room temperature for?
Definition
4-7 hours
Term
How long can blood be stored at room temperature for?
Definition
1-2 horus
Term
How long can plasma and serum be refrigerated for?
Definition
7 days
Term
How long can blood be refrigerated for?
Definition
24 hours
Term
How long can plasma and serum be frozen for?
Definition
4-6 weeks
Term
How long can blood be frozen for?
Definition
not at all!
Term
What does PCV stand for?
Definition
packed cell volume
Term
A hematocrit is also called a...?
Definition
PCV
Term
What does a PCV show?
Definition
the proportion of cells and fluid in the blood
Term
What is the buffy coat?
Definition
the layer of white blood cells and platelets in a hematocrit tube
Term
How many tubes should be run during a PCV?
Definition
2
Term
For quality control, average the results of the PCV tubes. What percentage must the numbers be in to be accurate?
Definition
2% or within 2 whole numbers of each other
Term
Low hematocrit numbers indicate what?
Definition
anemia
Term
High hematocrit numbers indicate what?
Definition
dehydration
Term
A large buffy coat indicates what?
Definition
a high WBC count
Term
A small buffy coat indicates what?
Definition
a low WBC count
Term
TP or TTP stands for what?
Definition
total plasma protein
Term
What does TP or TTP evaluate?
Definition
protein levels, indicating hydration status
Term
What is Hgb?
Definition
hemoglobin
Term
What is leukocytosis?
Definition
increased WBCs
Term
What is leukopenia?
Definition
decreased WBCs
Term
What is a phagocyte?
Definition
a cell that eats other cells
Term
What is a pinocyte?
Definition
a cell that ingests fluid from other cells
Term
What does lyse mean?
Definition
to destroy
Term
Whate are lysozymes?
Definition
enzymes that destroy bacteria
Term
Whate are lysozymes?
Definition
enzymes that destroy bacteria
Term
What are antibodies?
Definition
proteins that fight antigens
Term
What are antigens?
Definition
protein markers on an invader cell
Term
What are the 6 functions of white blood cells?
Definition
1. to control inflammation
2. to provide immunity
3. a memory bank of antigens
4. to aid with flot formation and destruction
5. to control bacterial and parasitic infections
6. to clean up material in blood that is not needed
Term
What is chromatin?
Definition
the complex of DNA and protein that makes up chromosomes and is found inside the nuclei
Term
What are the two types of white blood cells?
Definition
1. granulocytes
2. agranulocytes
Term
What are the three types of granulocytes?
Definition
1. basophils
2. eosinophils
3. neutrophils
Term
What are the two types of agranulocytes?
Definition
1. lymphocytes
2. monocytes
Term
What is a left shift?
Definition
when more than 5% of neutrophils are bands
Term
What are neutrophils attracted to?
Definition
inflammation
Term
What do neutrophils lyse?
Definition
bacteria, yeast algae and parasites
Term
How many segments does a neutrophil have?
Definition
3-5
Term
What is a neutrophil with more than 5 segments called?
Definition
a hypersegmented neutrophil
Term
What is neutrophilia?
Definition
an increase in neutrophils
Term
What causes neutrophilia?
Definition
1. response to imflammation
2. bacterial infections
3. stress
Term
What is neutropenia?
Definition
a decrease in neutrophils
Term
What causes neutropenia?
Definition
1. viral infections
2. actue leukemia 3. chemotherapy
4. vitamin B12 deficiency
5. splenomegaly
Term
How long can a lymphocyte live?
Definition
a week but some retain memory for more than 20 years, giving immunity
Term
What color cytoplasm does a stained lymphocyte have?
Definition
very little light blue cytoplasm
Term
What are the functions of a lymphocyte?
Definition
1. to fight viral infections
2. to provide memory to the immune system
Term
What are the two subclasses of lymphocytes?
Definition
T-cells and B-cells
Term
What is lymphocytosis?
Definition
an increase in lymphocytes
Term
What are the causes of lymphocytosis?
Definition
1. viral infections
2. certain cancers
3. leukemias
Term
What is lymphocytopenia?
Definition
a decrease in lymphocytes
Term
What are the causes of lymphocytopenia?
Definition
1. chronic infection
2. chemotherapy
Term
What is it called when there are more lymphocytes than neutrophils?
Definition
an inverted differential
Term
What are reactive lymphocytes?
Definition
lymphocytes that have been activated by the immune system from a viral infection
Term
What is another name for a monocyte?
Definition
a macrophage
Term
What is the largest WBC?
Definition
the monocyte
Term
What are the functions of a monocyte?
Definition
1. quckliy move to the site of inflammation and infection
2. phagocytosis
3. inducing clotting by generation of clotting factors and lysing activators
4. break down invadoes and instruct T lymphocytes to process antigens
Term
What is monocytosis?
Definition
an increase in monocytes
Term
What are the causes of monocytosis?
Definition
1. inflammatory disease
2. infections or fever
3. necrosis caused by infection
4. obstructions
Term
What are the main functions of eosinophils?
Definition
1. involvment in inflammatory process 2. contain protein to bind and damage parasite membranes
3. releases histamines in allergic inflammation
4. can decrease or worsen the inflammation response
5. engulfs and detoxifies bacteria
Term
For each eosinophil in the blood, how many are in the tissue?
Definition
300
Term
What is eosinophilia?
Definition
an increase in eosinophils
Term
What is eosinopenia?
Definition
a decrease in eosinophils
*this can be normal
Term
What are thought to be the main functions of a basophil?
Definition
1. release of histamine in inflammatory responses
2. releases heparin to prevent blood from clumping
Term
What is basophilia?
Definition
an increase in basophils
Term
What is basopenia?
Definition
a decrease in basophils
*this is normal
Term
What are the causes of basophilia?
Definition
1. increase is seen when eosinophils increase
2. hyperthyroidism / Cushing's disease
3. parasitic disease
4. allergies and respiratory disease
Term
What are the functions of thrombocytes?
Definition
1. hemostasis
2. secrete clotting substances
3. preserve capillary walls and plug holes
Term
What is thrombocytosis?
Definition
an increase in platelets
Term
What are the causes of throbocytosis?
Definition
1. adrenaline release
2. spontaneous bleeding
3. infection
4. post splenectomy
Term
What is thrombocytopenia?
Definition
a decrease in platelets
Term
What are the causes for thrombocytopenia?
Definition
1. decrease in production
2. bleeding disorder
3. hormone treatment
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