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- Largest part of the human brain - center of consciousness |
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thin (1/8 of an inch), highly convoluted layer of gray matter that covers surface of cerebrum - comprises over 40% of brain matter |
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Cerebral nuclei (basal nuclei) |
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several masses of gray matter embedded deep within the underlying white matter |
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4 main lobes of cerebral hemispheres |
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- frontal - parietal - temporal - occipital |
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interconnects the two hemispheres of the cerebrum |
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separates the cerebrum from the cerebellum |
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divides cerebrum into two cerebral hemispheres |
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ridges of the cerebral cortex |
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grooves of the cerebral cortex |
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separates the frontal lobe from the parietal lobe - a.k.a."Fissure of Rolando" |
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separates the temporal lobe from the frontal and parietal lobes |
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connect corresponding areas in the two hemispheres |
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transmit info within a single hemisphere |
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makes connections with other parts of the brain |
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Caudate nucleus, putamen, and globus pallidus - plays important role in helping to monitor and regulate muscle movements |
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heavily pigmented nucleus within the mid-brain |
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important inhibitory neurotransmitter |
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Damage to the basal nuclei causes: |
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muscular movement abnormalities, such as tremors, and disturbances in posture and muscle tone |
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3 Fibers of the white matter |
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Commissural, Association, and Projection |
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- located deep within the temperal lobe - structurally associatied with the basal nuclei, but funtionally part of the limbic system - involved in converting short-term memories into long-term memory |
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- "almond" - functions as the center for identification of danger - controls the expression of strong responses to danger such as fear, rage,and aggression |
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discrete area of the cerebral cortex where specific sensory and motor functions are localized |
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Crossing over of the major nerve tracts causes |
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each hemisphere to be concerned with sensory and motor functions on the opposite side of the body |
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- in the pre-central gyrus - controls the movement of specific skeletal muscles on the opposite side of the body |
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Motor Association Area (pre-motor) |
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- located immediately anterior to the pre-central gyrus - controls learned motor skills that involve repetitious patterns - damage to this area will cause the individual to have to relearn certain skills that require repetitious and coordinated contractions |
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Broca's Area (Speech Area) |
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- located in the lower part of the frontal lobe (usually in left hemisphere) - damage to this area often results in the inability to articulate words (aphasia) |
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a corresponding area in the hemisphere opposite Broca's area |
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controls voluntary movements of the eye |
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Where are the motor areas located? |
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- located in the post-central gyrus of each parietal lobe - sensory neurons in this area enable us to be aware of the body region being stimulated (spatial discrimination) |
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- located at the back of each occipital lobe - damage to visual cortex usually results in functional blindness |
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- located near the upper edge of each temporal lobe |
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located on the inner surface of each temporal lobe in a small lobe-like structure called the uncus |
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give rise to specific sensations |
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special areas of the cerebral cortex that enable us to make sense of what we feel, see, hear, etc. |
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- located in the occipital lobe - if damaged, the individual will not be able to recognize the things they see |
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2 Important General Association Areas |
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Prefrontal Cortex and Gnostic Area |
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- located in the front part of each frontal lobe - involved with personality |
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Gnostic Area (Wernike's Area) |
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- located in the parietal lobe - important in understanding and grasping concepts - damage will cause individual to become an imbecile |
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- dominant for language - has greater control over mathematical abilities and logic - for over 90% of people, the left hemisphere is the dominant hemisphere |
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- involved in intuition and artistic functions |
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How do the dominant hemisphere and the opposite hemisphere communicate? |
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through connecting tracts in the corpus callosum |
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involves transient changes in the electrical potential of certain nerve cells |
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- involves actual physical changes in the shape of certain neurons resulting in changes in neural pathways, thus forming a memory trace(memory engram) |
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conscious recollection of previous experiences and information |
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previous experiences aid the performance of a task without conscious awareness of the previous experience |
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- "emotional brain" - gives rise to strong emotions like fear,anger, love, pleasure, etc. |
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Main limbic structures of the diencephalon |
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hypothalamus and thalamus |
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Limbic structures in the cerebrum |
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olfactory cortex, hippocampus, amygdala, nucleus accumbens, and fornix |
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carries info from the hippocampus to the hypothalamus |
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- "reward rheostat" - stimulated by the neurotransmitter dopamine |
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emotional illness induced by disrupting the coordination between endocrine and nervous control |
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temporarily disables the system that removes dopamine from the nucleus accumbens |
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- a gyrus located on the medial surface of each cerebral hemisphere just above the corpus collosum (deep in the longitudinal fissure) - functions as a link between emotion and cognition - controls certain emotion-related facial movements, like the smile - abnormal and excessive activity is associated with compulsive-obsessive disorder (COD) |
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Reticular Activating System (RAS) |
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- intricate system of loosely clustered neurons distributed throughout white matter tracts in the brain stem - extends throughout the medulla oblongata, the pons, and the midbrain |
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Two main functions of the RAS |
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to arouse the cerebrum and to act as a sensory filter for info entering the brain |
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- located in the hypothalamus - inhibits the activity of the RAS |
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incapable of mitotic division (irreplaceable) |
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4 Ways the Brain is Protected |
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1) the cranial bones 2) the meninges 3) the cerebro-spinal fluid 4) the blood-brain barrier |
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- strong, flat bones held together by interlocking joints called sutures - curved shape of cranium makes it self-bracing |
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- three membranes that cover and protect the CNS - dura mater, arachnoid mater, and pia mater |
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- inflammation of the meninges - may allow bacteria or viruses to spread into the CNS |
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inward extensions or folds that anchor the brain to the cranial bones |
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Cerebrospinal fluid (CSF) |
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- found in subarachnoid space, ventricles of the brain, cerebral aquaduct, and central canal of spinal cord - cushions the brain, helps nourish the brain, and drains away metabolic wastes |
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frond-like masses of thin-walled blood capillaries located on the inner surface of the ventricles |
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Total volume of CSF in average adult |
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- 150 ml (1/2 cup) - replaced about every four hours |
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obstruction of the CSF circulation causing pressure to be exerted on the brain, leading to destruction of sensitive neurons |
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- important in protecting the brain from many harmful substances - capillaries are joined together by tight junctions, which make them much less porous and permeable - ineffective against fats, fatty acids, and fat soluble molecules |
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4 major advances of the nervous system |
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1) Nerve Nets 2) Ganglia 3) Superganglia 4) Brains |
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Difference in brains of lower vertebrates compared to humans |
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In lower vertebrates, areas devoted to smell and vision are dominant. In the human, cerebral hemispheres (particularly areas associated with associative functions) form the bulk. |
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small mass of neuron cell bodies from which axons can extend as nerves |
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formed by the fusion of several ganglia to form "primitive brain" |
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- fluid-filled tubular structure that is the first part of the nervous system - first step in the development of the brain |
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3 swellings of the neural tube |
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prosencephalon, mesencephalon, and rhomencephalon |
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gives rise to the cerebrum and the diencephalon |
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gives rise to the mid-brain |
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gives rise to the cerebellum and most of the brain stem |
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Fluid-filled cavity at center of neural tube |
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gives rise to the ventricles of the brain |
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3 primary regions of the brain |
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forebrain, midbrain, and hindbrain |
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consists of cerebrum and hippocampus |
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consists of the pons and cerebellum |
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3 structural differences between the male and female brain |
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the corpus callosum is thicker in females, the amygdala is larger in males, and the hippocampus is larger in females |
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Magnetic resonance imaging |
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positron-emission tomagraphy |
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Who has more communicating fibers b/w the 2 cerebral hemispheres? |
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"cerebro-vascular accident" |
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- condition that involves impairment of the brain's control of motor functions - usually caused by blockage of a cerebral blood vessel prior to birth - affects 1 in every 1000 births - causes seizures and learning disabilities |
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- caused by degeneration of neurons in the substancia nigra and the basal nuclei that produce dopamine - strikes in 50's and 60's - |
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Treatment for Parkinson's |
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- Levadopa - transplantation of dopamine producing fetal brain tissue into patients brain |
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Possible causes of Parkinson's |
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- frequent blows to the head - exposure to certain chemicals - inheritance |
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Structural changes in the brain tissue of patients with Alzheimer's |
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- neurofibrillar tangles - neuritic placques |
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Symptoms associated with Alzheimer's |
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shortened attention span, memory loss, disorientation, confusion, and personality changes |
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Neurotransmitter that declines in individuals with Alzheimer's |
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Why can some drugs cross the blood-brain barrier? |
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Areas of the brain affected by alcohol |
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reticular formation, cerebellum, and cerebral cortex |
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Chronic alcohol use causes |
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damage to frontal lobes, decrease in size of the brain, lower IQ, and memory impairment |
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3 neurotransmitters affected by cocaine |
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dopamine, norepinephrine, and serotonin |
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Neurological problems associated with cocaine abuse |
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movement problems, anxiety, depression, and hallucinations |
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Hallucinogenic substances found in certain mushrooms |
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