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Intro to Pathology & Disease
Definitions from 1st lecture
76
Pathology
Graduate
03/10/2012

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Term
Pathology
Definition
Branch of medicine that investigates disease, esp structural & funct’l changes in body tiss & organs that cause or are caused by disease
Term
Clinical Pathology
Definition
In medicine, refers to pathology applied to the SOLUTION of clinical problems, esp use of LABORATORY METHODS in clinical diagnosis
Term
Etiology
Definition
THE CAUSE of a disease or abnormal condit; or the STUDY OF FACTORS that lead to a disease
Term
Pathogenesis
Definition
Cellular events, rxns, & other pathologic mechanisms that occur during dvlpt of a disease
Term
Risk Factors
Definition
Variables associated c inc risk of diseases
Term
Health
Definition
State of complete physical, mental, & social well-being, and not merely the absence of disease or infirmity (WHO)
Term
Biopsychosocial Model of Health
Definition
Health reflects a person’s biological, psychological, spiritual & sociological state
Term
Biological Portion of Biopsychosocial Model
Definition
Overall structure of tiss’ & organs as wells as biochem interactions & functns
Term
Psychological Portion of Biopsychosocial Model
Definition
Person’s mood, emotions & personality
Term
Spiritual Portion of Biopsychosocial Model
Definition
Needs may affect or be affected by illness or injury
Term
Sociological Portion of Biopsychosocial Model
Definition
Refers to interaction between the individual and the social envir
Term
Illness
Definition
Sickness or deviation from a health state; BROADER meaning than disease; the PERCEPTION & response of the person to not being well; disturbances in biological functn; personal, interpersonal, & cultural rxns to disease
Term
Acute condition
Definition
Refers to an illness or disease that has a relatively rapid onset & short duration
Term
Chronic condition
Definition
Describes illness or disease that includes 1+ of the following chars: 1. Permanent impairment/disability, 2. Residual cognitive disability, 3. Need for special rehab &/or long-term medical management
Term
Disease
Definition
Refers to biologic or psychological alteration that results in malfunction of a body organ or system; OBJECTIVE DATA; can occur S PERSON BEING AWARE or illness
Term
Etiology
Definition
Cause of a disease, abnormal condit; or study of factors that lead to disease
Term
Diagnosis
Definition
Process of assigning a name to an individual’s disease or condition
Term
Syndrome
Definition
Cluster of findings (S&S) that are assoc c a disease or condit
Term
Symptoms
Definition
Evidence of disease perceived by an individual (SUBJECTIVE)
Term
Signs
Definition
Physical observations made by the indiv examining a pt (OBJECTIVE)
Term
Mortality Rate
Definition
# of people dying in a given period of time within a particular population, usually fro a particular disease or condition
Term
Morbidity Rate
Definition
# of cases of particular disease or condition occurring within a given period of time, per a specialized population unit
Term
Incidence
Definition
# of NEW cases of a disease/condition over a particular period of time (tells you about the risk of the condition)
Term
Prevalence
Definition
# of ALL cases (new+old) of a disease/condition at a given time (tells you about the extent of the condition)
Term
Prognosis
Definition
Expected outcome of a disease
Term
Hereditary Disease
Definition
Genetic diseases caused by an abnormal gene(s) or chromosome(s)
Term
Monogenic Disease
Definition
Single Gene; Inheritance patterns include Autosomal or sex-linked and dominant or recessive
Term
Polygenic Disease
Definition
Aka: Multifactorial Disorders; Dvlp from the interaction of several genes c multiple envir factors
Term
Chromosomal Disease
Definition
Genetic diseases caused by a defective, missing, or additional chromosome
Term
Aneuploidy
Definition
Alteration in normal # of chromosomes
Term
Partial Deletions of Chromosomes
Definition
Eg. Cri du Chat Syndrome
Term
Inversions
Definition
Reversal of order of the nucleic acids
Term
Translocations
Definition
Interchanging of genetic material between nonhomologous pairs of chromosomes
Term
Fragile Sites
Definition
Gaps & breaks in the chromosomes
Term
Congenital Disease
Definition
Disease that occurs as a result of occurrences during the dvlpt & are present at birth; but MAY OR MAY NOT have a hereditary cause
Term
Embryonic Anomalies
Definition
Malformations of body or organ structure occurring during the 1st -8th weeks of gestation
Term
Physical Injury Diseases (include:)
Definition
Mechanical, Thermal, Radiation
Term
Chemical Injury Diseases (include)
Definition
Drugs, Environmental Agents
Term
Normal Flora
Definition
Microorgs living on skin or in alimentary tract that do not produce illness
Term
Pathogens
Definition
Microorgs that produce disease when they gain entrance into the host
Term
Natural Defense Mechanisms
Definition
Epithelium, Inflammatory Processes, Immune Sys
Term
Bacterial Infections
Definition
Primary Infections (Exotoxins & Endotoxins) & Secondary (Opportunistic) Infections
Term
Exotoxins
Definition
Proteins (enzymes) released during bacterial growth that disrupt host cell metab or destroy host cell
Term
Endotoxins
Definition
Structural componenet in bacteria that is released when bacteria are destroyed (LPS) produce inflammatory response & are polygenic
Term
Secondary/Opportunistic Infections
Definition
Infections that occur when another disease predisposes an indiv to an infectious disease
Term
Viral Diseases
Definition
Viruses don’t produce exotoxins or endotoxins; Viruses proliferate within cells & take over metabolic machinery of the host cell & using it for their own survival & replication
Term
Venereal Diseases
Definition
Diseases commonly spread through genital contact, usually sexual intercourse
Term
Fungal (Mycoses) Diseases
Definition
1. Primary Systematic Fungal Infections 2. Opportunistic fungal infections 3. Superficial Fungal Infections
Term
Vascular Diseases
Definition
Major disease of the heart result from ischemic injury to cardiac mm, damaged heart valves, & inc work load caused by altered blood flow or increased pressure
Term
Hypertension
Definition
Elevation of blood pressure; 1. Systemic 2. Pulmonary 3.Renal
Term
Phlebitis
Definition
Inflammation of the Vein
Term
Thrombophlebitis
Definition
Blood clot formation usually due to sluggish & turbulent blood flow
Term
Athersclerosis
Definition
Narrowing of coronary vessels due to deposits in internal lining of blood vessels
Term
Thrombosis
Definition
Blood clot
Term
Embolism
Definition
Mobilized clot
Term
Angina Pectoris
Definition
Chest pain assoc c coronary ischemia or injury
Term
MI
Definition
Myocardial infarction; heart attack
Term
Stenosis
Definition
Valvular Disease; doesn’t open up all the way
Term
Insufficiency/Regurgitation
Definition
Valvular Diseas; doesn’t close all the way
Term
Immunosuppression Disease
Definition
Diseases in which there is too little response by the body to foreign antigen(s)
Term
Hypersensitivity Diseases
Definition
4 types (immunological diseases)
Term
Autoimmune Diseases
Definition
Hypersensitivity rxn to the body’s own tissues mediated by the immune sys
Term
Method & Endocrine Diseases (x4)
Definition
Thyroid, Parathyroid, Adrenal, Pancreas
Term
Thyroid Diseases
Definition
Hyper & Hypothyroidism
Term
Parathyroid Diseases
Definition
Regulates [Ca2+] in blood
Term
Adrenal
Definition
Addison’s disease & Cushings Syndrome
Term
Pancreas
Definition
Diabetes
Term
Neoplasm
Definition
New growth of tissue in which growth is uncontrolled & progressive (benign or malignant)
Term
Hyperplasia
Definition
Increase in the # of normal cells in normal arrangement (eg. calluses)
Term
Neoplasia
Definition
Increase in # of genetically abnormal cells that proliferate in non physiological manner
Term
Hypertrophy
Definition
Enlargement of an organ due to inc size of constituent cells
Term
Metastasis
Definition
Movement of cancerous cells via blood or lymph to a new (distant) site
Term
Grading
Definition
Histological differentiation of cancerous tiss
Term
Staging
Definition
Refers to degree of spread or metastasis
Term
Benign Neoplasm
Definition
Not cancerous; single masses of cells that remain localized at their site of origin & limited in growth; well defined borders; do not metastasixe
Term
Malignant Neoplasm
Definition
Have the potential to invade & metastasize
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