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Branch of medicine that investigates disease, esp structural & funct’l changes in body tiss & organs that cause or are caused by disease |
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In medicine, refers to pathology applied to the SOLUTION of clinical problems, esp use of LABORATORY METHODS in clinical diagnosis |
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THE CAUSE of a disease or abnormal condit; or the STUDY OF FACTORS that lead to a disease |
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Cellular events, rxns, & other pathologic mechanisms that occur during dvlpt of a disease |
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Variables associated c inc risk of diseases |
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State of complete physical, mental, & social well-being, and not merely the absence of disease or infirmity (WHO) |
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Biopsychosocial Model of Health |
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Health reflects a person’s biological, psychological, spiritual & sociological state |
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Biological Portion of Biopsychosocial Model |
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Overall structure of tiss’ & organs as wells as biochem interactions & functns |
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Psychological Portion of Biopsychosocial Model |
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Person’s mood, emotions & personality |
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Spiritual Portion of Biopsychosocial Model |
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Needs may affect or be affected by illness or injury |
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Sociological Portion of Biopsychosocial Model |
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Refers to interaction between the individual and the social envir |
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Sickness or deviation from a health state; BROADER meaning than disease; the PERCEPTION & response of the person to not being well; disturbances in biological functn; personal, interpersonal, & cultural rxns to disease |
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Refers to an illness or disease that has a relatively rapid onset & short duration |
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Describes illness or disease that includes 1+ of the following chars: 1. Permanent impairment/disability, 2. Residual cognitive disability, 3. Need for special rehab &/or long-term medical management |
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Refers to biologic or psychological alteration that results in malfunction of a body organ or system; OBJECTIVE DATA; can occur S PERSON BEING AWARE or illness |
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Cause of a disease, abnormal condit; or study of factors that lead to disease |
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Process of assigning a name to an individual’s disease or condition |
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Cluster of findings (S&S) that are assoc c a disease or condit |
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Evidence of disease perceived by an individual (SUBJECTIVE) |
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Physical observations made by the indiv examining a pt (OBJECTIVE) |
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# of people dying in a given period of time within a particular population, usually fro a particular disease or condition |
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# of cases of particular disease or condition occurring within a given period of time, per a specialized population unit |
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# of NEW cases of a disease/condition over a particular period of time (tells you about the risk of the condition) |
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# of ALL cases (new+old) of a disease/condition at a given time (tells you about the extent of the condition) |
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Expected outcome of a disease |
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Genetic diseases caused by an abnormal gene(s) or chromosome(s) |
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Single Gene; Inheritance patterns include Autosomal or sex-linked and dominant or recessive |
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Aka: Multifactorial Disorders; Dvlp from the interaction of several genes c multiple envir factors |
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Genetic diseases caused by a defective, missing, or additional chromosome |
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Alteration in normal # of chromosomes |
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Partial Deletions of Chromosomes |
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Reversal of order of the nucleic acids |
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Interchanging of genetic material between nonhomologous pairs of chromosomes |
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Gaps & breaks in the chromosomes |
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Disease that occurs as a result of occurrences during the dvlpt & are present at birth; but MAY OR MAY NOT have a hereditary cause |
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Malformations of body or organ structure occurring during the 1st -8th weeks of gestation |
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Physical Injury Diseases (include:) |
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Mechanical, Thermal, Radiation |
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Chemical Injury Diseases (include) |
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Drugs, Environmental Agents |
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Microorgs living on skin or in alimentary tract that do not produce illness |
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Microorgs that produce disease when they gain entrance into the host |
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Natural Defense Mechanisms |
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Epithelium, Inflammatory Processes, Immune Sys |
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Primary Infections (Exotoxins & Endotoxins) & Secondary (Opportunistic) Infections |
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Proteins (enzymes) released during bacterial growth that disrupt host cell metab or destroy host cell |
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Structural componenet in bacteria that is released when bacteria are destroyed (LPS) produce inflammatory response & are polygenic |
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Secondary/Opportunistic Infections |
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Infections that occur when another disease predisposes an indiv to an infectious disease |
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Viruses don’t produce exotoxins or endotoxins; Viruses proliferate within cells & take over metabolic machinery of the host cell & using it for their own survival & replication |
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Diseases commonly spread through genital contact, usually sexual intercourse |
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Fungal (Mycoses) Diseases |
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1. Primary Systematic Fungal Infections 2. Opportunistic fungal infections 3. Superficial Fungal Infections |
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Major disease of the heart result from ischemic injury to cardiac mm, damaged heart valves, & inc work load caused by altered blood flow or increased pressure |
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Elevation of blood pressure; 1. Systemic 2. Pulmonary 3.Renal |
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Blood clot formation usually due to sluggish & turbulent blood flow |
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Narrowing of coronary vessels due to deposits in internal lining of blood vessels |
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Chest pain assoc c coronary ischemia or injury |
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Myocardial infarction; heart attack |
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Valvular Disease; doesn’t open up all the way |
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Insufficiency/Regurgitation |
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Valvular Diseas; doesn’t close all the way |
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Immunosuppression Disease |
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Diseases in which there is too little response by the body to foreign antigen(s) |
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Hypersensitivity Diseases |
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4 types (immunological diseases) |
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Hypersensitivity rxn to the body’s own tissues mediated by the immune sys |
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Method & Endocrine Diseases (x4) |
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Thyroid, Parathyroid, Adrenal, Pancreas |
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Regulates [Ca2+] in blood |
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Addison’s disease & Cushings Syndrome |
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New growth of tissue in which growth is uncontrolled & progressive (benign or malignant) |
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Increase in the # of normal cells in normal arrangement (eg. calluses) |
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Increase in # of genetically abnormal cells that proliferate in non physiological manner |
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Enlargement of an organ due to inc size of constituent cells |
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Movement of cancerous cells via blood or lymph to a new (distant) site |
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Histological differentiation of cancerous tiss |
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Refers to degree of spread or metastasis |
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Not cancerous; single masses of cells that remain localized at their site of origin & limited in growth; well defined borders; do not metastasixe |
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Have the potential to invade & metastasize |
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