Term
Name the 3 types of
Microbial Control Methods |
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Definition
Physical Agents
Chemical Agents
Mechanical Removal Agents |
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Term
What applications are involved in the use of Physical Agents? |
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Definition
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Term
What applications are involved in using Chemical Agents? |
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Definition
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Term
What application is involved in using Mechanical Agents? |
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Definition
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Term
Who is responsible for choosing appropriate microbial control methods? |
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Definition
Microbial Control
Method Officer |
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Term
True or False
Microbial control methods eradicate microbes. |
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Definition
False: they reduce the number of microbes, and
may eradicate, but they
don't always. |
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Term
True or False
It's harder to kill spores than to kill vegetative forms. |
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Definition
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Term
To kill endospores
apply moist heat at
120° or 100ºC?
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Definition
Endospores killed at 120ºC
with moist heat.
Heat is a physical control method. |
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Term
To kill vegetative forms
apply moist heat at
80° or 100ºC? |
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Definition
Vegetative forms are killed at 80ºC using moist heat.
Heat is a physical control method. |
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Term
To kill endospores
apply 4,000 or 5,000
grays of radiation?
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Definition
Endospores are killed
using 4,000 grays of radiation.
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Term
To kill vegetative forms
apply 1,000 or 1,500
grays of radiation?
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Definition
Vegetative forms are killed with 1,000 grays of radiation.
Radiation is a physical killing agent. |
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Term
To kill endospores
apply 1,000 mg/l or
1,200 mg/l of sterilizing gas?
What IS the gas used?
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Definition
Endospores are killed by
applying 1,200 mg/l of sterilizing gas (ethylene oxide). (remember ethyl alcohol??)
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Term
To kill vegetative forms
apply 900 mg/l or
700 mg/l of sterilizing gas?
What IS the gas used?
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Definition
Vegetative forms are killed by
applying 700 mg/l of sterilizing gas (ethylene oxide). (remember ethyl alcohol??) |
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Term
Endospores are killed after 3 days or 3 hours of exposure to sporicidal liquid?
>>Name the liquid. |
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Definition
Endospores are killed after 3 hours of exposure to a sporicidal liquid:
2% glutaraldehyde. |
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Term
How long does it take a sporicidal iquid to kill vegetative forms? |
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Definition
10 minutes
(Sporicidal liquids are chemical agents.) |
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Term
Killing endospores and vegetative cells is an art.
True or False? |
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Definition
False - killing endospores and vegetative forms is a SCIENCE. |
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Term
Cadenas statement about use of control agents
and bacterial resistance: |
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Definition
Higher resistance by endospores compared to vegetative forms is an argument for needing more Microbial Control Method Officers.
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Term
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Definition
Book: a process that destroys or removes all viable microorganisms, including viruses.
Cadenas: one should ask, "If not destroyed, where have the M/Os been moved, and where are they now?" |
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Term
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Definition
Book: any material that has been subjected to the process of destruction or removal of all viable microorganisms, including viruses.
Cadenas: THIS IS STRAIGHTFORWARD |
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Term
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Definition
Book: a chemical that destroys bacteria except for those in the endospore stage. It may or may not be effective on other microbial groups.
Cadenas: no further comment
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Term
Chopping up a capsid to destroy a virus is using what method of microbial control? |
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Definition
STERILIZATION DESTROYS OR REMOVES ALL VIABLE M/Os - this includes viruses.
THIS WAS MENTIONED DURING SECTION ON DEFINITIONS. Chopping up viral capsids is a way to destroy viruses.
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Term
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Definition
Book: a chemical that CAN kill fungal spores, hyphae and yeasts.
Cadenas: THIS IS NOT LIMITED TO FUNGI, PER THE DEFINITION. USE OF THE WORD CAN INDICATES THAT IT'S NOT ALWAYS EFFECTIVE.
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Term
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Definition
Book: any chemical known to inactivate viruses, especially on living tissue.
Cadenas: THE VIRUSES ARE NOT KILLED BECAUSE VIRUSES ARE NOT ALIVE.
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Term
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Definition
Book: an agent which prevents the growth of bacteria on tissues or on objects in the environment.
Cadenas: STASIS = STOPPING/CEASING OF MOTION/TO STAND STILL. **this is a BACKUP MECHANISM used because a bactericide may not have killed all the bacteria. This would be Step 2.
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Term
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Definition
Book: the use of a physical process or a chemical agent (a disinfectant) to destroy vegetative pathogens but not bacterial endospores. (...usually only on inanimate objects)
Cadenas: WOULD NEED TO FOLLOW UP W/ANOTHER METHOD TO TAKE CARE OF SPORES LEFT BEHIND.
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Term
What is a
VEGETATIVE PATHOGEN? |
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Definition
Cadenas note:
veg. pathogen is a fully-grown disease-causing pathogen. |
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Term
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Definition
Book: the growth of microorganisms in the blood and other tissues.
Cadenas: IMPORTANT TO REMEMBER THAT SEPSIS IS NOT LIMITED TO BLOOD. One should ask,"How far has sepsis progressed? New/lingering infection? Any other tissues involved?"
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Term
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Definition
Book: any practice that prevents the entry of infectious agents into sterile tissues and thus prevents infection.
Cadenas: THIS IS PREVENTATIVE, WHICH IS A MAJOR FOCUS IN HEALTHCARE.
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Term
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Definition
(just a "Cadenas-ism")
Sanitization: any cleansing technique that removes debris, microorganisms, and toxins, and in this way reduces potential for infection and spoilage.
Cadenas: SPORES ARE INCLUDED IN THIS! DEBRIS = food for M/Os.
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Term
3 Cadenas suggestions re: qualities of chemical agents used by healthcare workers... |
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Definition
- Killing spores ≠ always killing bacteria.
- You should monitor drugs being removed from market, has legal and health implications.
- Know drugs you are administering, you'll need to monitor therapeutic levels.
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Term
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Definition
Microbes targeted: SLOW sporicidal
Leval of Activity: Intermediate
Toxicity: ↑ toxic gas (vapors), skin irritant
Inactivated by organics, unstable in sunlight.
Cadenas: NOT bacteriostatic or bactericidal AT ALL. Can introduce problems due to cracks in skin. Strong enough to kill spores ≠ strong enough to kill bacteria.
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Term
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Definition
Microbes targeted: SLOW sporicidal
Leval of Activity: Intermediate
Toxicity: Tissue irritant, Toxic to ingest
Cadenas: NOT TO BE LEFT IN ROOM WITH PATIENTS OF ANY AGE. Also, many believe that if it hurts, it must be clean!
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Term
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Definition
Microbes targeted: Most bacteria, viruses, fungi
Leval of Activity: Intermediate
Toxicity: Toxic to ingest, mild irritant, dries skin
also Flammable, fast-acting
Cadenas: no comment
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Term
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Definition
Microbes targeted: Certain very sensitive species
Leval of Activity: VERY LOW
Toxicity: Nontoxic, few if any toxic effects
Cadenas: USED FOR REMOVING SOIL, OIL, DEBRIS. More effective soaps lift both + and - charged items from surface or skin.
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Term
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Definition
Microbes targeted: WEAKLY microbistatic
Leval of Activity: LOW
Toxicity: HIGHLY Toxic to ingest, inhale, absorb
Cadenas: USED OUTSIDE OF THE U.S. THESE DAYS. This does not kill ANYTHING, and barely even slows down the M/Os.
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Term
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Definition
Microbes targeted: Sporicidal
Leval of Activity: HIGH
Toxicity: Can irritate skin, Toxic if absorbed
Cadenas: EMPHASIZED HIGH LEVEL OF TOXICITY IF ABSORBED.
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Term
TRUE OR FALSE
Soaps kill microorganisms. |
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Definition
False:
soaps only lift surface debris, etc. from skin.
Only added antimicrobial chemicals would kill some M/Os.
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Term
SOAPS:
cationic soaps are
preferable why? |
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Definition
Cationic soaps/detergents have:
molecules with a + charged end
(binds with - charged bacterial surface proteins)
and
an uncharged hydrocarbon chain which
helps lyse M/O cell membrane.
(p. 343) |
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Term
>>>we have to know ALL OF TABLE 12.1 ON P. 352
characteristics of the
IDEAL ANTIMICROBIAL DRUG |
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Definition
- Selectively toxic to _______ but nontoxic to _____.
- Microbicidal rather than microbi________.
- Relativley soluble; functions even when highly diluted in ________ fluids.
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Term
>>>we have to know ALL OF TABLE 12.1 ON P. 352
characteristics of the
IDEAL ANTIMICROBIAL DRUG
(continued) |
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Definition
4. Remains potent long enough to act and is not _________ or _______ prematurely.
5. Doesn't lead to the development of _______. (Hint: Cadenas also stated that we don't want drug to allow Transformation.) |
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Term
>>>we have to know ALL OF TABLE 12.1 ON P. 352
characteristics of the
IDEAL ANTIMICROBIAL DRUG
(continued) |
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Definition
6. Complements or assists the activities of the host's ___.
7. Remains active in tissues and _____.
8. Readily delivered to the site of _____.
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Term
>>>we have to know ALL OF TABLE 12.1 ON P. 352
characteristics of the
IDEAL ANTIMICROBIAL DRUG
(continued) |
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Definition
9. Reasonably priced.
10. Does not disrupt the host's health by causing ____ or predisposing the host to other ____. |
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Term
Name the 5 mechanisms for Antimicrobials
(the targets for these drugs) |
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Definition
1) inhibition of cell wall synthesis
2) breakdown of the cell membrane structure or function
3) inhibition of structures and functions of DNA and RNA
4) inhibition of protein synthesis
5) blocks on key metabolic pathways (via enzymes)
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Term
What is the
Therapeutic Index? |
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Definition
The measure (an indicator)
of a drug's toxicity |
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Term
Therapeutic Index
Is a TI of 10 better
than a TI of 1.1? |
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Definition
a TI of 10 is much better. A lower ratio such as 1.1 indicates that the
MINIMUM effective (therapeutic dose)
is very close to the toxic dose |
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Term
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Definition
Book: An individual who inconspicuously
shelters a pathogen and spreads
it to others without any notice. |
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Term
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Definition
Book: a live animal that transmits an infectious agent from one host to another |
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Term
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Definition
Book: an infection indigenous to animals but naturally transmissible to humans. |
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Term
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Definition
Book: describes disease when an infected host can transmit the infectious agent to another host and establish infection in that host |
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Term
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Definition
Book: when an infectious agent is highly communicable, especially through direct contact |
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Term
Define
NOSOCOMIAL INFECTION |
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Definition
Book: infectious diseases that are acquired or develop during a hospital stay |
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