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Definition
Bind Cytoplasmic Receptors, Receptor/Hormone complex enters nucleus activating transcription of proteins leading to hormone response |
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Bind Membrane Receptor, GTP Activation of AC produces cAMP which activates PKinase which leads to phosphorylation of substrates and hormone effect/response |
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Definition
DNA recombinant Growth Hormone, used in the treatment of Pituitary Dwarfism |
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DA Agonist, used for Paridoxical inhibitory effect on Growth Hormone release (Tx Acromegaly) ALSO Dopamine inhibits Prolactin Release (Tx Hyperprolactinemia) |
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Definition
Analog of Somatostatin with a long half life. Inhibits GH release and is used in the Tx of esophogeal Varices by decreasing portal pressure |
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Definition
Stimulates Growth and development of Mammary Glands Causes Lactation after Delivery Can enhance tumor growth and incidence of breast tumors |
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Definition
Circulating Angiontensin II and K+ regulate production of Aldosterone |
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Term
Zona Fasciculata/Reticularis |
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Definition
ACTH Stimulates production of Cortisol and Androgens |
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Definition
Leads to formation of Cortisol and Corticosterone |
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Definition
Required for formation of Cortisol and Androgens |
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Definition
When blocked, fully blocks Cortisol and Mineralcorticoid formation. (Salt-Wasting) |
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Definition
Synthetic ACTH, Used to Access state of adrenal cortex |
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Definition
Primary Adrenal Insufficiency. Deficient Cortisol due to diseased adrenal cortex, Excess ACTH and Hyperpigmentation |
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Secondary Adrenal Insufficiency. Deficient Cortisol due to insufficient ACTH production by Pituitary. Cortex will respond to ACTH, but response my not be normal due to Cortex atrophy from decreased stimulation. |
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Term
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Definition
Pituitary Dependent Adrenal Hyperplasia-Excessive Cortisol. Excess ACTH Secretion (adenoma of PITUITARY). More cortisol required for negative feedback, but will eventually be able to see negative feedback response. |
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Excessive Cortisol from Multiple Possible Causes 1) Adrenal Adenoma- Not ACTH Dependent 2) ACTH secreting ectopic tumor (normally in Lung) 3) Excessive Tx with Steroids |
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Definition
Antifungal that also blocks 17 Alpha-Hydroxylase Blocks formation of Cortisol and Androgens |
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Definition
Blocks the conversion of Cholesterol to Pregnenolone decreasing the synthesis of all corticosteroids. Useful in the Tx of Breast Cancer because it Also blocks Aromatase therefore decreased Estrogen formation |
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Definition
Blocks 11 Beta-Hydroxylase. Used in the diagnosis of adrenal insufficiency by checking ACTH and Cortisol precursor levels after administration. |
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Definition
Pure Glucocorticoid with very long duration of action (36-72hours) Used to Tx inflammation and Autoimmune |
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Term
Prednisone, Prednisolone, Methylprednisolone |
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Definition
Glucocorticoid with minimal Mineralcorticoid action |
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Term
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Definition
Pure Mineralcorticoid Used to Tx Salt Wasting |
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