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Intro to Endocrine
Recognition Quiz
22
Pharmacology
Graduate
11/06/2011

Additional Pharmacology Flashcards

 


 

Cards

Term
Steroid Hormones
Definition
Bind Cytoplasmic Receptors, Receptor/Hormone complex enters nucleus activating transcription of proteins leading to hormone response
Term
Protein Hormones
Definition
Bind Membrane Receptor, GTP Activation of AC produces cAMP which activates PKinase which leads to phosphorylation of substrates and hormone effect/response
Term
Somatropin
Definition
DNA recombinant Growth Hormone, used in the treatment of Pituitary Dwarfism
Term
Ropinirole
Definition
DA Agonist, used for Paridoxical inhibitory effect on Growth Hormone release (Tx Acromegaly) ALSO Dopamine inhibits Prolactin Release (Tx Hyperprolactinemia)
Term
Octreotide
Definition
Analog of Somatostatin with a long half life. Inhibits GH release and is used in the Tx of esophogeal Varices by decreasing portal pressure
Term
Prolactin
Definition
Stimulates Growth and development of Mammary Glands
Causes Lactation after Delivery
Can enhance tumor growth and incidence of breast tumors
Term
Zona Glomerulosa
Definition
Circulating Angiontensin II and K+ regulate production of Aldosterone
Term
Zona Fasciculata/Reticularis
Definition
ACTH Stimulates production of Cortisol and Androgens
Term
11 Beta-Hydroxylase
Definition
Leads to formation of Cortisol and Corticosterone
Term
17 Alpha-Hydroxylase
Definition
Required for formation of Cortisol and Androgens
Term
21 Beta-Hydroxylase
Definition
When blocked, fully blocks Cortisol and Mineralcorticoid formation. (Salt-Wasting)
Term
Cosyntropin
Definition
Synthetic ACTH, Used to Access state of adrenal cortex
Term
Addison's Disease
Definition
Primary Adrenal Insufficiency. Deficient Cortisol due to diseased adrenal cortex, Excess ACTH and Hyperpigmentation
Term
Addison's Syndrome
Definition
Secondary Adrenal Insufficiency. Deficient Cortisol due to insufficient ACTH production by Pituitary. Cortex will respond to ACTH, but response my not be normal due to Cortex atrophy from decreased stimulation.
Term
Cushing's Disease
Definition
Pituitary Dependent Adrenal Hyperplasia-Excessive Cortisol. Excess ACTH Secretion (adenoma of PITUITARY). More cortisol required for negative feedback, but will eventually be able to see negative feedback response.
Term
Cushing's Syndrome
Definition
Excessive Cortisol from Multiple Possible Causes
1) Adrenal Adenoma- Not ACTH Dependent
2) ACTH secreting ectopic tumor (normally in Lung)
3) Excessive Tx with Steroids
Term
Ketoconazole
Definition
Antifungal that also blocks 17 Alpha-Hydroxylase
Blocks formation of Cortisol and Androgens
Term
Aminogluthemide
Definition
Blocks the conversion of Cholesterol to Pregnenolone decreasing the synthesis of all corticosteroids.
Useful in the Tx of Breast Cancer because it Also blocks Aromatase therefore decreased Estrogen formation
Term
Metyrapone
Definition
Blocks 11 Beta-Hydroxylase. Used in the diagnosis of adrenal insufficiency by checking ACTH and Cortisol precursor levels after administration.
Term
Dexamethasone
Definition
Pure Glucocorticoid with very long duration of action (36-72hours) Used to Tx inflammation and Autoimmune
Term
Prednisone, Prednisolone, Methylprednisolone
Definition
Glucocorticoid with minimal Mineralcorticoid action
Term
Fludrocortisone
Definition
Pure Mineralcorticoid Used to Tx Salt Wasting
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