Zonula occludens

tight junctions

zonula adherens

in epithelial cells, like tight junctions, but more basal

desmosome

aka macula adherens, cell-to-cell adhesion in squamous epithelial tissue

gap junctions

ion channels between cells

nuclear lamina

fibrillar mesh network within nucleus, formed by lamin proteins

Nuclear Pore Complex

formed by specific proteins regulating movement of materials in and out of nucleus

nucleolus

site of rRNA transcription and ribo subunit assembly

Ribo subunits

large 60S

small 40S

RER function

synth, folding and glycosylation of integral memb, secretory and lysosomal proteins

lipid synth

SRP receptor

binds ribosome to RER membrane

SER function

lipid synth (phospholipid and steroid)

glycogenesis (esp in liver)

detox (oxidation and methylation rxns)

Ca2+ metabolism in sarcoplasmic reticulum

Golgi function

oligosaccharide chain processing

glycosylation and deglycosylation of proteins/lipids

proteoglycan assembly

phosphorylation/sulfation of proteoglycans and proteins

proteolyic processing of polypeptides

Endosomes (4 subtypes)

coated pits/vesicles (receptor mediated endocytosis--Clathrin and Clathrin assoc proteins)

early endosomes (endo/pinocytosis, still may have clathrin, acidic interior--receptor-ligand sep)

late endosomes (no surface receptors, fuse w lysosomes)

carrier vesicles (transfer material early-->late)

Lysosomes

lytic enzymes, fuse w late endosomes to form phagolysosome and digest material

peroxisomes

enxyme=catalase, which acts on hydrogen peroxide

enzymes for beta-ox of long chain fatty acids

other than the whole ATP thing, mitochondria do what?

store calcium, divalent cation metabolism

microfilaments

actin and actin-assoc proteins

microtubules

tubulin (alpha and beta isoforms alternate to form polymeric protofilament. N=13 --> microtubule)

Microtubule Associated Proteins (ex kinesin and dynein)

anti-inflammatory fn

intermediate filaments

functions not well-defined

regulate cell shape

diff proteins--> tissue type markers

Desmin--muscle cells

Vimentin--mesenchymal cells

Neurofilament protein--neuronal cells

keratins--epithelial cells

glial fibrillar proteins--glial cells