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the basic building blocks of the nervous system |
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large protein molecules embedden in the cell's membrane; each particular type of receptor and its matching neutransmitter fit together like a "lock & key" |
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Greek for "tree". specialized receiving units (like antennae) that collect messages from neighboring neurons & send them on to the cell body |
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the cell body, containts the biochemical structures necessary to keep the neuron alive |
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Greek for "glue" Functions: to surround neurons & hold them in place to supply nutrients & oxygen to neurons to absorb toxins & waster materials that would damage or kill neurons |
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a whitish, fatty insulation layer that surrounds the axon of many neurons, derived from glial cells during development; causes action potential to travel faster; damage -> multiple sclerosis: one's own immune system attacks the myelin sheath |
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conducts electrical impulses away from the cell body to other neurons, muscles or glands |
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a nerve impulse - an electrical charge that travels along an axon |
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where PSPs summate; threshold voltage |
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regulate the flow of ions (Na+, K+, Cl−) across the membrane in all cells |
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secrete chemicals called neutransmitters |
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chemical substances that carry messages across the synaptic spae to other neurons, muscles or glands |
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chambers within the axon terminals, where transmitter molecules are stored |
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a fluid-filled gap btwn the axon terminal button of one neuron & the dendrite of the next neuron |
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Inactivation/Deactivation |
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inactivation (by enzymes) or removal (drifting away) of neutransmitters |
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neutransmitters are taken back into the terminal button of the pre-synaptic neuron to be recycled & used again |
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excitatory neurotransmitter |
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binds to a receptor causing sodium ions to rush into the soma |
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inhibitory neurotransmitter |
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binds to a matching receptor & causes a negative voltage shift |
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excitatory post-synaptic potential |
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increase the likelihood of an action potential traveling down the axon |
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inhibitory post-synaptic potential |
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decreases the likelihood of an action potential being stimulated in the soma |
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post-synaptic potentials a change in the elctrical potential of a neuron that is proportional to the intensity of the incoming stimulation but not sufficient to produce an action potential |
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occurs when multiple PSPs follow one another in rapid succession at a single receptor site, the voltage at the axon hillock can reach threshold |
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occurs when multiple PSPs occur in rapid succession at DIFFERENT receptor sites, the voltage at the axon hillock can reach threshold |
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resting potential (polarization) |
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the internal difference of around -70 mV |
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action potential (depolarization) |
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a brief shift in the neuron's electrical charge (-70 mV -> +40 mV) that travels down an axon (sprint!) |
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immediately after an action potential electrical charge restored to resting potential |
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absolute refractory period |
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the min length of time after an AP during which another AP cannot begin occurs during repolarization sodium channels won't open, because the sodium-potassium pumps have not yet moved the sodium back outside the axon |
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action potentials occur at a uniform & maximum intensity, or they do not occur at all |
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drugs that block the action of neutransmitters |
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drugs that mimic the action of neutransmitters |
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involved in normal attention, memory, movement |
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low levels of ACh drugs increase ACh activity to improve memory (agonist) |
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involved in normal bodily response to pain |
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mutes signals of pain from the body & produces a "high" because it travels into the brain & binds to neurons w/ endorphin receptors -- it mimcs endorphins & is therefore an endorphin agonist |
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involved in normal attention, learning, memory, wakefulness/arousal, eating |
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involved in normal emotional states, impulse control, sleep & dreaming |
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involved in normal ability to return the brain from high state of arousal back to normal after an anxiety-provoking event imbalance: epileptic seizures anxiety disorders drugs: valium & xanax (agonists) |
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involved in normal motivation/feelings of pleasure, motor control, planning |
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can occur when levels of dopamine are too low in the basal ganglia |
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includes psychotic delusions and hallucinations due to too high levels of dopamine activity in the frontal lobe of the cerebral cortex |
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reduce dopamine to relieve psychotic symptoms of schizophrenia, but can have a side effect of causing motor tremors & depression |
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carry input messages from the sense organs to the spinal cord & brain |
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perform connective or associative functions within the nervous sytem far outnumber sensory & motor neurons |
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transmit output impulses from the brain & spinal cord to the body's muscles & organs |
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contains the brain & the spinal cord, which connects most parts of the peripheral nervous sytem w/ the brain |
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connects the brain to the rest of the nervous system |
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Peripheral Nervous System |
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contains all the neural structures that lie outside of the brain & the spinal cord |
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division of PNS conscious sensation & voluntary movement |
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(somatic) carry sensory info from body (sense, organs, skin, gut) to CNS |
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(somatic) carry conscious moto commads from CNS to body |
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(PNS) controls automatic, involuntary gut & skin functions such as heart rate, digestion, perspiration, getting goosebumps & other types of physiological arousal that happen w/ emotion |
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mobilizes the body's resources for emergencies (heart rate & blood pressure increase, release of hormones that ready the body for exertion, slows digestion) |
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slows down, restores the body's resources after mobilization (heart rate & blood pressure drop, promotes digestion) - affecting one or a few organs at a time |
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a delicately balanced or constant internal state |
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(hindbrain) regulates vital functions such as breathing & heart rate damage usually results in death |
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involved in sleep & arousal |
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(hindbrain? midbrain? a poorly-differentiated area...) acts as a sentry - alerts highers centers that messages are coming in & either sends them forward or blocks them plays a role in consciousness, sleep & attention |
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(hindbrain) Latin "little brain" coordinates fine muscle movement (typing, playing an instrument...) & balance alcohol impacts cerebellum before most other parts of the brain |
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(midbrain) the orienting center: receives info so we can react quickly using the twisting & movement centers elsewhere in the brain system |
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(forebrain) links the nervous system to the endocrine system via the pituitary gland; Regulation of basic biological drives related to survival - the four F's: feeding, fighting, fleeing and mating. Motivation & emotion... also body temp., circadiam rhythms, blood pressure, blood sugar, etc. |
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the master gland of the body regulates other endocrine glands that release hormones |
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(forebrain) the sensory switchboard organizes input from sensory organs & routes them to the appropriate areas of the brain |
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(forebrain, limbic system) forming & retrieving memories |
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(forebrain, limbic system) organizes motivational & emotional responses patterns, particularly those linked to fear & agression |
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medial forebrain bundle (MFB) & nucleus accumbens |
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(forebrain) We experience pleasure when neurons release dopamine on the nucleus accumbens - "reward centers/circuits" - linked to daily pleasures like eating or addictive drugs like cocaine... |
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(forebrain) crucial for planning & producing, movement - translating thoughts into action signals from cortex are sent to brainstem |
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(cerebral cortex (cerebrum)) executive functions - goal setting, judgment, strategic planning, interprets social cues & impulse control damage can lead to subtle but important changes in personality & cognitive ability the primary motor cortex also controls voluntary body movement |
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executive functions - goal setting, judgment, strategic planning, interprets social cues & impulse control |
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in the frontal lobe language output (communicating to others) |
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(frontal lobe) voluntary body movement |
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plays important roles in integrating sensory information from various parts of the body |
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receives sensory input that give rise to our sensations of heat, touch, cold & to our senses of balance & body movement |
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primary visual cortex - sight! |
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primary auditory cortex: hearing |
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(temporal lobe) language input (understanding) |
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a loss of the ability to produce and/or comprehend language, due to injury to brain areas specialized for these functions. It is not a result of deafness or muscle paralysis, and it does not necessarily affect intelligence. |
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connects the 2 cerebral hemispheres (left & right) allows information to pass from one to the other |
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the degree to which the left or right hemispheres of the cerebral cortex control certain abilities |
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