Term
| Intranasal can be used for |
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Definition
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Term
3 nasal regions (**VRO)
Vestibular
Respiratory
Olfactory |
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Definition
Vestibular=nasal vestibule & valve
Respiratory= extends 6-8cm backwards.inc SA &turbulence
[3 turbinates Inferior,Middle,Superior]
Olfactory= Roof of nasal canal
[poorly ventilated, close to CNS. Potential for Rx delivery to brain. Very Small SA] |
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Term
| Which nasal region is major region for rx absorption |
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Definition
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Term
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Definition
Anterior=1/3 resp region(varying epithelia)
Posterior=2/3 resp region(gud for abs due to only have 1 cell layer)
[ciliated pseudostratified epithelium,mucociliary clearance]
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Term
Mucociliary clearance
Mucus
Cilia
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Definition
occurs in posterior of resp reg
Mucus=protects epi,trap/transports substances(especially rx and undsolved stuff) pH 6.3
Cilia= function in coordination ot move mucus[mucus moved posteriorly]
clearanc 15- 20 mins for inhaled sub |
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Term
| one of most important factors physiologically affecting nasal drug absorption |
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Definition
Mucociliary clearance
[less enzyme act than intestines] |
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Term
| Nasal blood supply is _______ and not drained to _____ |
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Definition
highly vascularized(can absorb large molecules)
hepatic portal system |
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Term
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Definition
Naferelin (generic)[peptide]
for central precocious puberty, nasasl cavity contains fenestrated caps |
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Term
| Nasal associated lymphoid tissue vaccine used intranasal |
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Definition
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Term
| nasal complicated by these conditions |
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Definition
Physiologic=rhinitis,asthma,hay fever,nasal polyps
environmental=humidity,temp,some rx dry nasal secretion |
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Term
| Dose form design concepts(***POVPD) |
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Definition
pH=4-8(ciliary beat best at 7-10)
Osmolarity=isotonic liquids preferred
Viscosity = affects drug fate(high slows clearance)
Preservation= Antimicrobial preservatives are usually included in the formulation
dRUG DISPOSITION=form spray vs drop() |
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Term
Spray=deposited in anterior
Drop= generally get greaer coverage |
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Definition
| sprays=metered dosed aerosol pressurized |
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Term
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Definition
Description=pressurized aerosol vs mechanical pump
Particle size= 8-20 um in diameter impact the nasal cavity
Spray bottle design= designed to reach nasal valve |
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Term
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Definition
butorphanol tartrate(generic)
nasal spray=used for pain relief(systemic)
extensive first pass
aqueous sol |
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Term
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Definition
budesonide
used for allergic rhinitis(local inflammation)
20% reaches sys absorption
metered dosedpressurized inhaler
(micronized budesonide suspended in propellants) |
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Term
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Definition
Mupirocin calcium
ointment 2% nasal colonizaion of MRSA |
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