• Includes all constituents of the body located outside of the cells.

Body Fluids

• Water contet of body devided into 2 compartment

1. 67% of total body is contained within cells, in the Intracellular Compartment.
2. 33% of totalt body  is found in the Extracellular Compartment

• 20% is contained within vessels of cardiovascular system, where it constitutes the fluid portion of the blood, or Blood Plasma.
• Remaining 80% is located outside the vascular system, and makes up the Tissue fluid, also called Interstitial Fluid. Fluid is contained in the gel-like extracellular matrix.

• 80% is located outside the vascular system, and makes up the Interstitial Fluid (AKA Tissue Fluid). Fluid is contained in the gel-like extracellular matrix.

Extracellular Matrix

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• Cells that compose organs in our body are embedded within extracellular material of connective tissues.

Consists of Protein Fibers

• Collagen and elastin
• Meshwork of Collagen and elastin fibers linked to molecules of gel-like ground substance (Interstitial) and to plasma membrane integrins.
•   Provide structural strength to the connective tissue.

• Also gives Shape to cells
• Resides in hydrated gel of ground substance

• A Class of glycoproteins that extend from the cytoskeleton within a cell, through its plasma membrane, and into the extracellular matrix
• Act as adhesion molecules, physically joining intracellular to the extracellular compartments.
• Integrate by relaying signals to each other
• Interaction creates a polarity
• affect cell adhesion in a tissue and the ability of certain cells to be motile. 

• Enzymes that can Break down extracellular matrix proteins
• Need for zinc cofactor
• Needed for tissue remodeling
• Secreted inactive
• Can contribute to disease processes if produced or activated inappropriately.
• Cancer cells produce active MMPs, that will break down collagen of basal lamina and allow cancerous cells to migrate

• Extracellular Fluid passes plasma membrane, blood plasma or derived from blood plasma.
• Cell memebrane seperates intracellular and extracellular compartments
• Molecules that come from the blood into interstitial fluid will eventually come into contact with the plasma membrane.
• Some Molecules can Penetrate (Permeate) the membrane, others may not. Also selective Ions. 
• Cell will be labeled Selectively Permeable